Recently I am researching about ANTI-MARKOVNIKOV HYDROAMINATION; CATALYZED INTRAMOLECULAR HYDROAMINATION; COUPLED ELECTRON-TRANSFER; UNACTIVATED ALKENES; INTERMOLECULAR HYDROAMINATION; RADICAL CYCLIZATION; GENERATION; PYRROLOINDOLINES; METHODOLOGY; EFFICIENT, Saw an article supported by the NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [R01 GM113105]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [R01GM113105] Funding Source: NIH RePORTER. Recommanded Product: 1,1,1-Triethoxyethane. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Nguyen, ST; Zhu, QL; Knowles, RR. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane
Olefin aminations are important synthetic technologies for the construction of aliphatic C-N bonds. Here we report a catalytic protocol for olefin hydroamidation that proceeds through transient amidyl radical intermediates that are formed via proton-coupled electron transfer (PCET) activation of the strong N-H bonds in N-alkyl amides by an excited-state iridium photocatalyst and a dialkyl phosphate base. This method exhibits a broad substrate scope, high functional group tolerance, and amenability to use in cascade polycyclization reactions. The feasibility of this PCET protocol in enabling the intermolecular anti-Markovnikov hydroamidation reactions of unactivated olefins is also demonstrated.
Recommanded Product: 1,1,1-Triethoxyethane. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Nguyen, ST; Zhu, QL; Knowles, RR or concate me.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com