Recently I am researching about D-MANNO-HEPTOSE; INNER-CORE; BINDING; GLYCOSIDES; LIPOPOLYSACCHARIDES; RECOGNITION, Saw an article supported by the Austrian Science Fund (FWF)Austrian Science Fund (FWF) [J 3449-N28]. Published in FRONTIERS MEDIA SA in LAUSANNE ,Authors: Suster, C; Baxendale, IR; Mihovilovic, MD; Stanetty, C. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane. Category: thiazolidines
Bacterial lipopolysaccharides (LPS) are important bio-medical structures, playing a major role in the interaction with human immune systems. Their core regions, containing multiple units ofl-glycero-d-mannoheptoses (l,d-heptose), are highly conserved structurally (withO3 andO7 glycosidic bonds), making them an epitope of high interest for the potential development of new antibiotics and vaccines. Research in this field has always been restricted by the limited availability of the parentl,d-heptose as well as its biochemical epimeric precursord-glycero-d-mannoheptose (d,d-heptose). This problem of availability has recently been solved by us, through a rapid and efficient practical synthesis ofl,d-manno-heptose peracetate demonstrated at scale. Herein we report an optimized, technically simple and versatile synthetic strategy for the differentiation of both thel-glyceroandd-glycero-d-mannoheptose scaffolds. Our approach is based on an orthoester methodology for the differentiation of all three positions of the sugar core using aO6,O7-tetraisopropyl disiloxyl (TIPDS) protecting group for the exocyclic positions. Furthermore, the regioselective opening toward 7-OH acceptors (6O-FTIPDS ethers) differentiates the exocyclic diol which has been demonstrated with a broader set of substrates and for bothmanno-heptoses for the first time.
About 1,1,1-Triethoxyethane, If you have any questions, you can contact Suster, C; Baxendale, IR; Mihovilovic, MD; Stanetty, C or concate me.. Category: thiazolidines
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com