Related Products of 108-59-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 108-59-8, Name is Dimethylmalonate, SMILES is O=C(OC)CC(OC)=O, belongs to thiazolidines compound. In a article, author is Wang, Shi-Ben, introduce new discover of the category.
Synthesis and Evaluation of Anticonvulsant Activities of 5-Benzylidene-2-(5-methylisoxazol-3-ylimino)thiazolidin-4-one Derivatives
Fifteen new 5-benzylidene-2-(5-methylisoxazol-3-ylimino)thiazolidin-4-one derivatives (4-18) were synthesized and evaluated for their preliminary anticonvulsant activity and neurotoxicity by using the maximal electroshock (MES) and rotarod tests. The structures of synthesized compounds were established by IR, H-1 NMR, C-13 NMR and mass spectral data. Among the compounds studied, 5-(3-fluorobenzylidene)-2-(5-methylisoxazol-3-ylimino)thiazolidin-4-one (8) was the most potent compound, with a median effective dose of 43.9 mg/kg and a high protective index (PI) of more than 11.1 after intraperitoneal administration in mice. Compound 8 showed significant oral activity against MES-induced seizures in mice, with an ED50 of 84.2 mg/kg and a PI above 11.8. These results demonstrate that compound 8 is safer than the commercially drugs.
Related Products of 108-59-8, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 108-59-8.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com