Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 593-85-1, 593-85-1, Name is guanidinecarbonate, SMILES is NC(=N)N.NC(=N)N.OC(=O)O, belongs to thiazolidines compound. In a document, author is Thakral, Samridhi, introduce the new discover.
A synthetic approach and molecular docking study of hybrids of quinazolin-4-ones and thiazolidin-4-ones as anticancer agents
A series of 3-(4-(2-(aryl)-4-oxothiazolidin-3-yl)phenyl-2-phenylquinazolin-4(3H)-one derivatives were synthesized in appreciable yield by using anthranilic acid as a starting material. The structures of synthesized compounds (QT1-QT10) were confirmed on the basis of various spectral techniques and analytical methods. These synthesized compounds were screened for their in vitro antitumor activity against the human breast cancer cell line (MCF-7), human hepatocellular cancer cell line (HepG2) using MTT assay method and doxorubicin as a standard drug. Compound 3-(4-(2-(3-chlorophenyl)-4-oxothiazolidin-3-yl)phenyl-2-phenylquinazolin-4(3H)-one (QT4) showed comparable cytotoxic activity against Hep-G2 cell line. Compound 3-(4-(2-(4-methoxyphenyl)-4-oxothiazolidin-3-yl)phenyl-2-phenylquinazolin-4(3H)-one (QT5) showed comparable cytotoxic activity against MCF-7 cell line while QT6, QT7, QT8 were the less cytotoxic as they showed high IC50 and away from that of doxorubicin. The remaining compounds did not show significant activity against both the cell lines. To understand the interaction of series with active binding site of receptor, docking study was performed with topoisomerase-II co-crystallized with adenylyl-imidodiphosphate complex using AutoDockVina. There was a good correlation between in vitro and in silico study. Thus, this investigation leads to the identification of newer anticancer agents.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 593-85-1. Recommanded Product: 593-85-1.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com