Site-Specific Chemical Modification of Peptide and Protein by Thiazolidinediones was written by Wang, Peng;Zhang, Shumei;Meng, Qiuyue;Liu, Ying;Shang, Luqing;Yin, Zheng. And the article was included in Organic Letters in 2015.Reference of 16312-21-3 This article mentions the following:
A direct aldol reaction employing 2,4-thiazolidinediones as nucleophilic donors was performed to modify peptides and protein under mild conditions. Various functional groups could be readily introduced into protein without conformation change. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Reference of 16312-21-3).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidines unsubstituted on the nitrogen atom are readily hydrolyzed by boiling aqueous solutions of acids or bases and the dissociation is complete in the presence of a compound reacting with one of the cleavage products.Reference of 16312-21-3
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com