Crystal structure of 7′-(4-chlorophenyl)-2′′-(4-methoxyphenyl)-7′,7a′,7′′,8′′-tetrahydro-1′H,3′H,5′′H-dispiro[indoline-3,5′-pyrrolo[1,2-c]thiazole-6′,6′′-quinoline]-2,5′′-dione and an unknown solvent was written by Vishnupriya, R.;Venkateshan, M.;Suresh, J.;Sumesh, R. V.;Kumar, R. Ranjith;Lakshman, P. L. Nilantha. And the article was included in Acta Crystallographica, Section E: Crystallographic Communications in 2019.Quality Control of Thiazolidine-4-carboxylic acid This article mentions the following:
The asym. unit of the title compound, C34H28ClN3O3S, contains two independent mols. (A and B). They differ essentially in the orientation of the 4-methoxyphenyl ring with respect to the pyridine ring of the quinoline moiety; this dihedral angle is 37.01 (18)° in mol. A but only 7.06 (17)° in mol. B. In both mols., the cyclohexanone ring of the isoquinoline unit has a half-chair conformation. In the pyrrolothiazole ring system, the pyrrolo ring in mol. A has a twisted conformation on the N-C fused bond and an envelope conformation in mol. B with the N atom as the flap. The thiazole rings of both mols. have twisted conformations on the N-C fused bond. In the crystal, the A mols. are linked by pairs of N-H···O hydrogen bonds, forming inversion dimers with an R22(8) ring motif. These dimers are linked to the B mols. by an N-H···N hydrogen bond and a series of C-H···O hydrogen bonds, forming layers lying parallel to the (101) plane. The layers are linked by C-H···π interactions and offset π-π interactions [intercentroid distance = 3.427 (1) Å], forming a supramol. framework. The contribution to the scattering from a region of highly disordered solvent mols. was removed with the SQUEEZE routine in PLATON [Spek (2015). Acta Crystalline C71, 9-18]. The solvent formula mass and unit-cell characteristics were not taken into account during refinement. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Quality Control of Thiazolidine-4-carboxylic acid).
Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Quality Control of Thiazolidine-4-carboxylic acid
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com