The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate( cas:2199-44-2 ) is researched.Safety of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate.Smith, Kevin M.; Miura, Michiko; Tabba, Hani D. published the article 《Deacylation and deformylation of pyrroles》 about this compound( cas:2199-44-2 ) in Journal of Organic Chemistry. Keywords: pyrrole acetyl formyl deacylation; deacylation acetylpyrrole; deformylation formylpyrrole. Let’s learn more about this compound (cas:2199-44-2).
3-Acetyl- and 3-formyl-pyrroles are smoothly deacylated using either ethanedithiol/BF3 or (more conveniently) ethylene or neopentyl glycols in presence of p-MeC6H4SO3H. The reaction does not proceed when the acetyl or formyl group is in the 2-position, and in these cases the corresponding ketal or acetal is isolated. A mechanism for the deacylation process is proposed and is confirmed by deacylation of a pyrrole I bearing a cyclopentanone ring; under these circumstances the cleaved group is retained in the pyrrole II, and is identified.
In addition to the literature in the link below, there is a lot of literature about this compound(Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate)Safety of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, illustrating the importance and wide applicability of this compound(2199-44-2).
Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com