Top Picks: new discover of 2-Cyanoimino-1,3-thiazolidine

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Application of 26364-65-8, When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. 26364-65-8, Name is 2-Cyanoimino-1,3-thiazolidine, molecular formula is C4H5N3S. In a Article,once mentioned of 26364-65-8

A new synthesis of 2-cyano-1-methyl-3-<2-<<(5-methyl-1-H-imidazol-4-yl)methyl>thio>ethyl>guanidine, 6 (cimetidine) utilizing the aziridine derivative 5 as a two-carbon one-nitrogen synthon, is reported.Attempts to prepare the key intermediate 5 via aziridine forming ring closure of 18, as well as attempted insertion of aziridine into the carbon-sulphur bond in 11 or 12 are described.Low yields of 6 were obtained both on insertion of aziridine within 12, and on alkylation of 14 with 8, followed by decomposition of the sulphonium salt 15.Formation of 5 from 2 and aziridine in the presence of Ag(I) ions is found to follow predominantly an elimination-addition mechanism, via the highly unstable carbodiimide 4, rather than direct substitution.

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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H634N | ChemSpider