Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products, Quality Control of guanidinecarbonate, 593-85-1, Name is guanidinecarbonate, molecular formula is C3H12N6O3, belongs to thiazolidines compound. In a document, author is Eroglu, Barbaros, introduce the new discover.
Novel Thiazolidinone-Azole Hybrids: Design, Synthesis and Antimycobacterial Activity Studies
To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of Schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-Benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to Knoevenagel condensation. To evaluate their structures H-1 NMR, IR, mass spectrometry and elemental analysis data were used. The target compounds were screened for their antimycobacterial activity against M. tuberculosis H37Rv strain using the microplate alamar blue assay method. Among them, 6, 10 and 12 (MIC: 14.27-14.74 mu M) were found as most active compounds in the series. It was seen that both phenylamino and benzylidene substitutions on thiazolidin-4-one ring caused an improvement in the antimycobacterial activity.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 593-85-1. Quality Control of guanidinecarbonate.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com