Reference of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, is researched, Molecular C9H13NO2, CAS is 2199-44-2, about Detection and Prevention of Aggregation-based False Positives in STD-NMR-based Fragment Screening. Author is Vom, Amelia; Headey, Stephen; Wang, Geqing; Capuano, Ben; Yuriev, Elizabeth; Scanlon, Martin J.; Simpson, Jamie S..
Aggregation of small organic compounds is a problem encountered in a variety of assay screening formats where it often results in detection of false positives. A saturation transfer difference-NMR-detected screen of a com. available fragment library, followed by biochem. assay, identified several inhibitors of the enzyme ketopantoate reductase. These inhibitors were subsequently revealed to be aggregation-based false positives. Modification of the fragment screen by addition of detergent in the saturation transfer difference-NMR experiments allowed an assay format to be developed that resulted in the identification of genuine hit mols. suitable for further development.
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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com