Safety of 1,1,1-Triethoxyethane. Recently I am researching about POSITIVE ALLOSTERIC MODULATORS; HIGH-AFFINITY; PHARMACOLOGICAL EVALUATION; DISCOVERY; LIGANDS; PAIN; IDENTIFICATION; INHIBITORS; SCAFFOLDS, Saw an article supported by the MIUR Progetto Dipartimenti di Eccellenza 2018-2022. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Mugnaini, C; Rabbito, A; Brizzi, A; Palombi, N; Petrosino, S; Verde, R; Di Marzo, V; Ligresti, A; Corelli, F. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane
A set of CB2R ligands, based on the thiophene scaffold, was synthesized and evaluated in in vitro assays. Compounds 8c-i, k, 1, bearing the 3-carboxylate and 2-(adamantan-1-yl)carboxamido groups together with apolar alkyl/aryl substituents at 5-position or at 4- and 5-positions of the thiophene ring possess high CB2R affinity at low nanomolar concentration, good receptor selectivity, and agonistic functional activity. The full agonist 8g, showing the best balance between receptor affinity and selectivity, was tested in vitro in an experimental model of allergic contact dermatitis and proved to be able to block the release of MCP-2 in HaCaT cells at 10 mu M concentration. (C) 2018 Elsevier Masson SAS. All rights reserved.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com