Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 6117-80-2, Name is (Z)-But-2-ene-1,4-diol, molecular formula is , belongs to thiazolidines compound. In a document, author is Sayeed, Faizan, Computed Properties of C4H8O2.
DESIGN,, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NEW SUBSTITUTED THIAZOLIDIN-4-ONE DERIVATIVES
4-thiazolidinones are among the most extensively investigated class of organic compounds. Thiazolidin-4-one has been considered as magic moiety, which is a core structure in various synthetic pharmaceuticals displaying a broad spectrum of biological activities. They are widely used as anti-inflammatory, anticonvulsant, analgesic, antimicrobial, anti-HIV, CNS depressant, carcinostatic, antihypertensive and cytotoxic. In view of the wide spectrum activities of condensed 4-thiazolidinones, it was thought worthwhile to undertake the synthesis of heterocyclic systems in which 4-thiazolidinone nucleus is linked to another biologically active moiety. Semicarbazide/Thiosemicarbazide was reacted with benzoyl chloride to obtain N-hydrazinocarbonyl benzene-1-carboxamide/N-hydrazinocarbothioylbenzene-1 carboxamide respectively. These were then condensed with various aldehydes to yield the intermediate Schiff bases. Thiazolidin-4-ones were prepared by the reaction of Schiff bases with mercaptoacetic acid in dry benzene by refluxing for 16-18 hours. The purity of the compounds synthesized was established by TLC. The synthesized derivatives were characterized by FT-IR, (HNMR)-H-1 and Mass spectral analysis. All the derivatives synthesized were screened for their anti-bacterial and antifungal activities using cup-plate method against Bacillus subtilis, Salmonella typhi, Escherichia coli, Staphylococcus aureus, Aspergillus niger and Candida albicans at 100 mu g/ml using ciprofloxacin and clotrimazole as reference standard drugs respectively. The compounds belonging to series (3A1-3A6) have shown promising antibacterial and antifungal activity and those belonging to series (3B1-3B6) were moderate compared to standard. The antimicrobial activity data reveals that, the compounds bearing the phenyl carbonyl urea in their structure, were found to be more potent than the phenyl carbonyl thiourea containing derivatives, indicating the influence of oxygen in enhancing the antimicrobial potency.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 6117-80-2, in my other articles. Computed Properties of C4H8O2.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com