Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 5908-62-3, Name is 1,1-Dioxo-isothiazolidine. In a document type is Article, introducing its new discovery., 5908-62-3
Electron-deficient olefin ligands enable generation of quaternary carbons by Ni-catalyzed cross-coupling
A Ni-catalyzed Negishi cross-coupling with 1,1-disubstituted styrenyl aziridines has been developed. This method delivers valuable beta-substituted phenethylamines via a challenging reductive elimination that affords a quaternary carbon. A novel electron-deficient olefin ligand, Fro-DO, proved crucial for achieving high rates and chemoselectivity for C-C bond formation over beta-H elimination. This ligand is easy to access, is stable, and presents a modular framework for reaction discovery and optimization. We expect that these attributes, combined with the fact that the ligands impart distinct electronic properties to a metal, will support the invention of new transformations not previously possible using established ligands.
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Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H573N | ChemSpider