Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 542-05-2, Name is 3-Oxopentanedioic acid, molecular formula is C5H6O5. In an article, author is Pachuta-Stec, Anna,once mentioned of 542-05-2, Safety of 3-Oxopentanedioic acid.
Design, synthesis, structure elucidation and in vitro antiviral and antimicrobial evaluation
In this study, we described the synthesis of the derivatives of thiosemicarbazide, dicarboximide, 1,2,4-triazole-5-thione and 4-oxo-1,3-thiazolidine. Two different dicarboxylic acid anhydrides reacted with 4-substituted-3-thiosemicarbazide, and derivatives of thiosemicarbazide and dicarboximide were obtained. Next, cyclization reaction of dicarboximide derivatives in alkaline media was used to prepare 1,2,4-triazole-5-thione. The 4-oxo-1,3-thiazolidine was synthesized by the reaction of dicarboximide with ethyl bromoacetate. All obtained derivatives were analysed by H-1 and C-13 NMR spectra, and for one compound, the X-ray crystallography was done. Antimicrobial, antiviral and in vitro evaluations of cytotoxicity were examined. According to the preliminary antiviral screening, compounds 3 and 4 presented the antiviral activity against HSV-1 and CVB3. Additionally, compound 3 shows selective in vitro toxic effect against human epithelial cells FaDu, without affecting normal animal cell line (Vero). The same derivatives 3 and 4 also displayed a wide spectrum of antimicrobial activity against reference microorganisms and indicated both antibacterial and antifungal potential activities.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com