Application of 99-86-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 99-86-5, Name is 1-Isopropyl-4-methylcyclohexa-1,3-diene, SMILES is CC(C)C1=CC=C(C)CC1, belongs to thiazolidines compound. In a article, author is Shao, Jie, introduce new discover of the category.
Synthesis of tetracyclic azasugars fused benzo[e][1,3]thiazin-4-one by the tandem Staudinger/aza-Wittig/cyclization and their HIV-RT inhibitory activity
Azasugar aldehydes 6a and 6b containing azido groups were prepared from D-mannose. Three novel tetracyclic azasugars fused benzo[e][1,3] thiazin-4-one 9a-1, 9a-2 and 9a-3 were conveniently synthesized from 6a by the tandem intramolecular Staudinger/aza-Wittig/cyclization reaction under microwave radiation. Two unexpected elimination compounds 8b-1 and 8b-2 were achieved as the main products from 6b in the same processes. The newly synthesized azasugars were examined for their HIV reverse transcriptase (RT) inhibitory activities. The results showed that all the tested compounds could effectively inhibit RT activity. Among them, compound 8b-1 with the protective group (isopropylidene group) was the best one with the IC50 value of 0.76 mu M. The structure activity relationship analysis suggested that improvement of the molecular hydrophilicity might be beneficial for their anti-HIV RT activities. (C) 2017 Elsevier Ltd. All rights reserved.
Application of 99-86-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 99-86-5.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com