Tag: M.W=300-400

In an article, author is Tymoshuk, Oleksandr, once mentioned the application of 2421-28-5, Name is Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride, molecular formula is C17H6O7, molecular weight is 322.23, MDL number is MFCD00005923, category is thiazolidines. Now introduce a scientific discovery about this category, Formula: C17H6O7.

Spectrophotometric Determination of Ru(IV) Using 5-Hydroxyimino-4-imino-1,3-thiazolidin-2-one as a Novel Analytical Reagent

The interaction of Ru(IV) ions with a novel analytical reagent – 5-hydroxyimino-4-imino-1,3-thiazolidin-2-one, by spectrophotometric method was investigated. The complex is formed at pH 5.0 in acetate buffer medium after heating in the boiling water bath (similar to 371 K) for 25 min. The complex has maximum absorption at 350 nm and is stable for 24 h. Beer’s law is valid over the concentration range of 0.5-6.1 mu g mL(-1) for Ru(IV). The molar absorptivity at lambda= 350 nm is 6.21 x 10(3) L mol(-1) cm(-1). The limit of detection of this method is 0.2 mu g mL(-1). The interfering effect of various cations and anions on the spectrophotometric determination of the Ru(IV) were investigated. The proposed method was successfully applied to the determination of Ru(IV) in alloys.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Related Products of 2421-28-5, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 2421-28-5, Name is Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride, SMILES is O=C(C1=CC2=C(C(OC2=O)=O)C=C1)C3=CC4=C(C(OC4=O)=O)C=C3, belongs to thiazolidines compound. In a article, author is Cui, Liying, introduce new discover of the category.

Organocatalytic Enantioselective alpha-Amination of Thiazol-4-one-5-carboxylates with Azodicarboxylates

An effective method for the asymmetric synthesis of 5-hydrazinothiazol-4-one-5-carboxylates was developed. The tetrasubstituted chiral carbon center was generated by asymmetric amination of thiazol-4-one-5-carboxylate with azodicarboxylate catalyzed by a bifunctional squaramide-based (1R,2R)-cyclohexane-1,2-diamine backbone in good to excellent yields (40-96%) with high levels of enantioselectivity (92-98% ee). A representative transformation of the amination product to a biologically important 1,3,4-oxadiazol-2(3H)-one is achieved without any appreciable loss in enantioselectivity. Additionally, upon treatment with NaBH3CN, the amination product could also be converted into a biologically important thiazolidin-4-one derivative in good yield without any loss of stereochemical integrity.

Related Products of 2421-28-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 2421-28-5 is helpful to your research.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1823-59-2, Name is 5,5′-Oxybis(isobenzofuran-1,3-dione), molecular formula is C16H6O7. In an article, author is Marri, Srinivas,once mentioned of 1823-59-2, SDS of cas: 1823-59-2.

Synthesis and pharmacological evaluation of 3-(3,5-dimethylisoxazol-4-yl)-2-arylthiazolidin-4-ones as potential antioxidant, anti-inflammatory and analgesic agents

3-(3,5-Dimethylisoxazol-4-yl)-2-arylthiazolidin-4-ones 3a-1 have been synthesized from 4-amino-3,5-dimethylisoxazole 1 by condensation with aromatic aldehydes, followed by cyclization with mercaptoacetic acid in excellent yields, and have been evaluated for in vitro antioxidant activity. Based on potential antioxidant property, compounds 3c, 3e, 3h, 3i, and 3l have been screened for in vivo anti-inflammatory and analgesic activity. Molecular docking studies have also been carried out to balance the bioactivity results. From these results it is evident that the compound 3c shows potential anti-inflammatory and analgesic activity.

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Reference:
Thiazolidine – Wikipedia,
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Related Products of 1823-59-2, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 1823-59-2, Name is 5,5′-Oxybis(isobenzofuran-1,3-dione), SMILES is O=C1OC(C2=C1C=CC(OC3=CC4=C(C(OC4=O)=O)C=C3)=C2)=O, belongs to thiazolidines compound. In a article, author is Le Corre, Laurent, introduce new discover of the category.

Synthesis of Multifunctionalized 2-Iminothiazolidin-4-ones and Their 2-Arylimino Derivatives

Multifunctionalized 2-imino-3-(pyrazol-4-yl)thiazolidin-4-ones and 2-arylimino-3-(pyrazol-4-yl)thiazolidin-4-ones were prepared according to an efficient four-step procedure. The key step of the synthetic pathway involved the cyclization of 2-chloro-N-(pyrazol-4-yl)acetamide intermediate using KSCN or aryl isothiocyanate, respectively. The structure of the title compounds was confirmed on the basis of NMR data and N-15-labeling.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2421-28-5, Name is Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride, molecular formula is C17H6O7. In an article, author is Dadlani, V. G.,once mentioned of 2421-28-5, Category: thiazolidines.

DESIGN, SYNTHESIS AND IN-SILICO STUDY OF NOVEL SERIES OF 2-PHENYL-3-(5-SULFANYL-1,3,4-THIADIAZOL-2-YL)-1,3-THIAZOLIDIN-4-ONE DERIVATIVES WITH POTENTIAL ANTI-TUBERCULAR ACTIVITY

In an attempt to identify potential new agents active against tuberculosis with Shikimate kinase as the target, a novel series of 2-phenyl- 3-(5-sulfanyl-1,3,4-thiadiazol-2-yl)-1,3-thiazolidin-4-one derivatives were synthesized by convenient one-pot three-component reaction of amine, aldehyde and mercaptoacetic acid on montmorillonite KSF clay as a solid acidic catalyst in good yields. The structures of the newly synthesized compounds were confirmed by IR, H-1-NMR and elemental analysis and were subjected for anti-tubercular activity by Microplate Alamar Blue Assay (MABA) against Mycobacterium tuberculosis H37Rv. Docking and ADMET studies were used to better describe the titled compounds as potential anti-tubercular agents. The compound, 2-(3,4-dimethoxyphenyl)-3-(5-sulfanyl-1,3,4-thiadiazol-2-yl)-1,3-thiazolidin-4-one(4j), was found to be the most active against Mycobacterium tuberculosis H37Rv with MIC of 1.6 mu g/ml and good drug likeness and dock scores. Molecular docking study revealed that the molecules fit well into the cavity of Shikimate kinase. Also, the molecular properties and bioactivity scores for the synthesized compounds obtained by in-silico studies were found to be within the acceptable range defined for human use revealing their potential as possible drug-like compounds. The anti-tubercular activity of the titled compounds was comparable to that of the standard drug Isoniazid and Ciprofloxacin. The results indicate that the synthesized thiadiazolyl-thiazolidinone derivatives may have an affinity towards Shikimate kinase active site which can be further explored for selective target based studies. Thus these compounds could act as a potential lead for further anti-tubercular studies.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 1823-59-2, Name is 5,5′-Oxybis(isobenzofuran-1,3-dione), SMILES is O=C1OC(C2=C1C=CC(OC3=CC4=C(C(OC4=O)=O)C=C3)=C2)=O, in an article , author is Gowramma, B., once mentioned of 1823-59-2, Safety of 5,5′-Oxybis(isobenzofuran-1,3-dione).

Synthesis of Some Novel 2-Azetidinones/4-Thiazolidinones Bearing 1, 3, 4-Thiadiazole Nucleus and Screening for its Anti-Imflammatory Activity

Objective: The objective of the study was to synthesize a series of 3-chloro-4-(substituted phenyl)-1-(5-styryl-1, 3, 4-thiladiazole-2-yl) azetidin-2-one / 2-(substituted phenyl)-3-(5-styryl-1, 3, 4-thiadiazole-2-yl)-thiazolidin-4-one and screened for their possible anti-inflammatory activity by carrageenan induced paw edema in rats. Method: The synthesis of 2-amino-5-styryl-1, 3, 4-thiadiazole, an intermediate was carried out by oxidative cyclization method. In the current study, thiosemicarbazone (I) was subjected to oxidative cyclization using ferric chloride as an oxidising agent, to get 2-amino-5-styryl-1, 3, 4-thiadiazole (II). Futhermore, compound (II) was reacted with different aromatic aldehydes in methanol to form N-(4-sustituted)-5-styryl-1, 3, 4-thiadiazol-2-amine (III a-h). Compound (III a-h) was reacted with chloroacetyl chloride in triethylamine to form 2-azetidinone derivatives bearing 1, 3, 4-thiadiazole nucleus (IV a-h). Compound (III a-h) on cyclocondensation with mercaptoacetic acid leads to the formation of 4-thiazolidinone derivatives bearing 1, 3, 4-thiadiazole nucleus (V a-h). Results: The synthesis of the targeted compounds IV a-h and Va-h was confirmed through their MP, IR, H-1-NMR and mass spectrum studies. Compounds IVa, IVb and IVc (56.32, 61.11 and 58.24 % inhibition) exhibited significant anti-inflammatory activity than that of diclofenac (65.13% inhibition). Conclusion: It may be concluded that the presence of methoxy, nitro and hydroxyl phenyl groups substituting 2-azetidinone bearing 1, 3, 4-thiadiazole showed significant anti-inflammatory activity.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 1823-59-2, you can contact me at any time and look forward to more communication. Safety of 5,5′-Oxybis(isobenzofuran-1,3-dione).

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

1823-59-2, Name is 5,5′-Oxybis(isobenzofuran-1,3-dione), molecular formula is C16H6O7, Application In Synthesis of 5,5′-Oxybis(isobenzofuran-1,3-dione), belongs to thiazolidines compound, is a common compound. In a patnet, author is Ashraf, Saba, once mentioned the new application about 1823-59-2.

Design, Synthesis and Biological Evaluation of 2-(naphthoyl) iminothiazolidin-4-ones as Potential Anticancer Agents

A library of novel naphthyl bearing 2-iminothiazolidin-4-ones (2-ITZDs) (2 a-2 q) was designed and synthesized through a facile route involving regioselective heterocyclization of unsymmetrical thioureas (1 a-1 q). The synthesis was achieved at ambient temperature in good to excellent yields under catalyst free conditions. The molecular structures of 2-ITZDs were elucidated by spectroscopic techniques such as FT-IR, H-1-NMR and C-13-NMR. X-ray structural data was used to establish the structure (2 o) unequivocally and to define the geometry of exo double bond. The in vitro anticancer activity of 2-ITZDs (2 a-2 q) was investigated in several human cancer cell lines (A549, LNCap, PC-3, MDA-MB-231, BxPC3, MIA PaCa2). All compounds showed cytotoxicity with IC50 values ranging from 6-23 mu M in the tested cancer cell lines except MDA-MB-231. Compound 2 k (IC50=7 mu M) and the homologous analog 2 q (IC50=6 mu M) were found to be equipotent to 2 k and showed moderate cytotoxicity against human breast cell line (DA-MB-231). Furthermore, compound 2 k exhibited a medium permeability, enough metabolic stability and no significant inhibition of hERG channel. Compound 2 k inhibited cytochrome P450 activity below 50 % in 1 A2, 3 A4 and 2 C19, but not in 2 C9 and 2D6 at 10 mu M. Structure-activity relationships (SAR) provided useful insights towards this class of compounds and tiled a way to design novel analogues with increased potency.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

In an article, author is Popiolek, Lukasz, once mentioned the application of 2421-28-5, Computed Properties of C17H6O7, Name is Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride, molecular formula is C17H6O7, molecular weight is 322.23, MDL number is MFCD00005923, category is thiazolidines. Now introduce a scientific discovery about this category.

Synthesis, Dissociation Constants, and Antimicrobial Activity of Novel 2,3-Disubstituted-1,3-thiazolidin-4-one Derivatives

In this article, a new series of 2,3-disubstituted-1,3-thiazolidin-4-one derivatives have been designed, synthesized, and evaluated as antimicrobial agents. New compounds were prepared by the cyclization reaction of N-substituted carboxylic acid hydrazide derivatives with mercaptoacetic acid. The structures of the obtained compounds were confirmed by means of IR, H-1 NMR, and C-13 NMR spectra. The dissociation constants were determined using spectrophotometric method. All synthesized compounds were tested for their in vitro antibacterial and antifungal activities using the broth microdilution method.

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Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 2421-28-5, Name is Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride. In a document, author is Chulovska, Zoriana, introducing its new discovery. SDS of cas: 2421-28-5.

Synthesis of Some C-5 Substituted 4-Phenylimino-Thiazolidin-2-Ones as Possible Anti-Inflammatory Agents

Based on the Knoevenagel condensation, nitrosation, and azo coupling reactions, the synthesis of some C-5 substituted 4-phenylimino-thiazolidin-2-ones was carried out. The chemical structures of the synthesized products have been determined by H-1 NMR spectroscopy and elemental analysis. Evaluation of novel compounds over the carrageenan-summoned rat paw edema revealed a powerful anti-inflammatory effect of some substances which exceeds the activity of the comparative drug Ibuprofen.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 2421-28-5 help many people in the next few years. SDS of cas: 2421-28-5.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1823-59-2, Name is 5,5′-Oxybis(isobenzofuran-1,3-dione), molecular formula is C16H6O7. In an article, author is Singh, Ruby,once mentioned of 1823-59-2, Formula: C16H6O7.

An expedient synthesis of new imino-thiazolidinone grafted dispiro-pyrrolidine-oxindole/indeno hybrids via a multicomponent [3+2] cycloaddition reaction in a deep eutectic solvent

An expedient, one-pot regio- and stereo-selective synthesis of new imino-thiazolidinone grafted dispiro-pyrrolidine hybrids has been accomplished successfully by a green and sustainable method. The synthesis included a three component [3+2] cycloaddition reaction of 2-(arylimino)thiazolidin-5-ylidenes, substituted isatin/ninhydrin and sarcosine using choline chloride (ChCl) : urea (1 : 2) as a deep eutectic solvent (DES) in a single step. Among the variety of reaction conditions, the utilization of choline chloride : urea (1 : 2) at 80 degrees C was found to be the most effective reaction condition to achieve desired dispiropyrrolidines in excellent yield with high regio- and stereo-selectivity. This method is operationally simple with cleaner conversion to afford the target compounds in short reaction times and avoids the use of environmentally hazardous solvents, which make this globally putative. Moreover, the ChCl : urea (1 : 2) can be reused for over three repeated cycles without any noteworthy loss of activity.

Interested yet? Keep reading other articles of 1823-59-2, you can contact me at any time and look forward to more communication. Formula: C16H6O7.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com