Tag: M.W=200-250

In 2020.0 INT J MOL SCI published article about PHARMACEUTICAL APPLICATIONS; VAR ANGUSTIFOLIA; FLAVONOIDS; BIOSYNTHESIS; GENES; EXPRESSION; MEDICARPIN; MAACKIAIN in [Kim, Soyoung; Jeong, Yu Jeong; Park, Su Hyun; Park, Sung-Chul; Lee, Saet Buyl; Lee, Jiyoung; Kim, Suk Weon; Jeong, Jae Cheol; Kim, Cha Young] Korea Res Inst Biosci & Biotechnol KRIBB, Biol Resource Ctr, Jeongeup 56212, South Korea; [Kim, Soyoung; Ha, Bo-Keun] Chonnam Natl Univ, Coll Agr & Life Sci, Dept Plant Biotechnol, Gwangju 61186, South Korea; [Kim, Hyun-Soon; Kim, HyeRan] Korea Res Inst Biosci & Biotechnol KRIBB, Plant Syst Engn Res Ctr, Daejeon 34141, South Korea; [Ryu, Young] Korea Res Inst Biosci & Biotechnol KRIBB, Funct Biomat Res Ctr, Jeongeup 56212, South Korea in 2020.0, Cited 47.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Name: Chalcone

Pterocarpans are derivatives of isoflavonoids, found in many species of the family Fabaceae. Sophora flavescens Aiton is a promising traditional Asian medicinal plant. Plant cell suspension cultures represent an excellent source for the production of valuable secondary metabolites. Herein, we found that methyl jasmonate (MJ) elicited the activation of pterocarpan biosynthetic genes in cell suspension cultures of S. flavescens and enhanced the accumulation of pterocarpans, producing mainly trifolirhizin, trifolirhizin malonate, and maackiain. MJ application stimulated the expression of structural genes (PAL, C4H, 4CL, CHS, CHR, CHI, IFS, I3’H, and IFR) of the pterocarpan biosynthetic pathway. In addition, the co-treatment of MJ and methyl-beta-cyclodextrin (Me beta CD) as a solubilizer exhibited a synergistic effect on the activation of the pterocarpan biosynthetic genes. The maximum level of total pterocarpan production (37.2 mg/g dry weight (DW)) was obtained on day 17 after the application of 50 mu M MJ on cells. We also found that the combined treatment of cells for seven days with MJ and Me beta CD synergistically induced the pterocarpan production (trifolirhizin, trifolirhizin malonate, and maackiain) in the cells (58 mg/g DW) and culture medium (222.7 mg/L). Noteworthy, the co-treatment only stimulated the elevated extracellular production of maackiain in the culture medium, indicating its extracellular secretion; however, its glycosides (trifolirhizin and trifolirhizin malonate) were not detected in any significant amounts in the culture medium. This work provides new strategies for the pterocarpan production in plant cell suspension cultures, and shows Me beta CD to be an effective solubilizer for the extracellular production of maackiain in the cell cultures of S. flavescens.

Name: Chalcone. Welcome to talk about 94-41-7, If you have any questions, you can contact Kim, S; Jeong, YJ; Park, SH; Park, SC; Lee, SB; Lee, J; Kim, SW; Ha, BK; Kim, HS; Kim, H; Ryu, Y; Jeong, JC; Kim, CY or send Email.

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Formula: C15H12O. Authors Gaur, PK in ELSEVIER published article about in [Gaur, Praveen Kumar] ITS Coll Pharm, Dept Pharmaceut, Meerut Rd, Murad Nagar 201206, Ghaziabad, India in 2021.0, Cited 50.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

The present study was planned to apply the nanotechnology to therapeutically proven flavonoid-rich fraction for obtaining a formulation with enhanced antihyperglycemic activity. The leaves were extracted in aqueous methanol and fractionated to yield a flavonoid-rich fraction. This fraction was formulated into an aqueous nanosuspension using PVA through the nanoprecipitation method. The developed formulations were characterized for physical parameters and optimum nanosuspension was evaluated against type 2 diabetes in high-fat diet-fed, streptozotocin-induced diabetic animals. The pharmacokinetic parameter and histopathology were assessed to determine the kinetic profile and tissue architectures post oral administration of selected nano suspension. The selected nanosuspension was also studied for stability under accelerated conditions. Flavonoidrich fraction was obtained using Kupchan partitioning. The developed nanosuspension PG-EA-NS-B showed optimum physical parameters. In hyperglycemia induced by streptozotocin, in high-fat diet-fed rats, it effectively restores the normal level of blood glucose in the first hour. The effects were comparable to standard Glibenclamide. In biochemical observations, PG-EA-NS-B, as well as PG-EA, showed beneficial effects on various hepatic and renal parameters. The pharmacokinetic parameters showed that nanosuspension enhances the absorption and decreases the metabolism of flavonoid actives. The selected nanosuspension and free flavonoid fraction showed rectification of histological changes. The nanosuspension was most stable in cool conditions. PVA based nanosuspensions can be a viable strategy for oral delivery of natural flavonoids, as it significantly affected the absorption and metabolism of flavonoids upon oral administration.

Formula: C15H12O. Welcome to talk about 94-41-7, If you have any questions, you can contact Gaur, PK or send Email.

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Product Details of 94-41-7. Authors Sabah, KJ; Zahid, NI; Hashim, R in SPRINGER published article about in [Sabah, Karem J.] Univ Kufa, Dept Chem, Fac Sci, Najaf 54001, Iraq; [Zahid, N. Idayu; Hashim, Rauzah] Univ Malaya, Dept Chem, Ctr Fundamental & Frontier Sci Nanostruct Self As, Fac Sci, Kuala Lumpur 50603, Malaysia in 2021.0, Cited 34.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

A series of new mix aza- and thia-macrocyclic glycolipids (9, 111, 16 and 17) have been synthesized and their enantiomeric selectivity was studied. The synthesis of the macrocycles involved a simple protection of two hydroxyl groups of the glycolipids followed by building up the mix-heteroatom macrocyclic in simple sequences. The macrocycles and previously investigated analogues (la, n, a and 21) have been applied as phase transfer catalysts in the enantioselective Michael addition of 2-nitropropane to chalcone and showed good-to-excellent enantiomer excess (ee). Among the catalysts, the galactose aza-crown ether-based glycolipid 21 proved to be the most effective with 90% ee.

Product Details of 94-41-7. Welcome to talk about 94-41-7, If you have any questions, you can contact Sabah, KJ; Zahid, NI; Hashim, R or send Email.

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An article 2-Thiopyrimidine/chalcone hybrids: design, synthesis, ADMET prediction, and anticancer evaluation as STAT3/STAT5a inhibitors WOS:000521276700001 published article about OVERCOME DRUG-RESISTANCE; CHALCONE DERIVATIVES; MOLECULAR TARGETS; LEUKEMIA; CANCER; STAT3; APOPTOSIS; POTENT; DOMAIN; SRC in [Lamie, Phoebe F.; Philoppes, John N.] Beni Suef Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Bani Suwayf 62514, Egypt in 2020.0, Cited 50.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Category: thiazolidines

A novel 2-thiopyrimidine/chalcone hybrid was designed, synthesised, and evaluated for their cytotoxic activities against three different cell lines, K-562, MCF-7, and HT-29. The most active cytotoxic derivatives were 9d, 9f, 9n, and 9p (IC50=0.77-1.74 mu M, against K-562 cell line), 9a and 9r (IC50=1.37-3.56 mu M against MCF-7 cell line), and 9a, 9l, and 9n (IC50=2.10 and 2.37 mu M against HT-29 cell line). Compounds 9a, 9d, 9f, 9n, and 9r were further evaluated for their cytotoxicity against normal fibroblast cell line WI38. Moreover, STAT3 and STAT5a inhibitory activities were determined for the most active derivatives 9a, 9d, 9f, 9n, and 9r. Dual inhibitory activity was observed in compound 9n (IC50=113.31 and 50.75 mu M, against STAT3 and STAT5a, respectively). Prediction of physicochemical properties, drug likeness score, pharmacokinetic and toxic properties was detected.

Category: thiazolidines. Bye, fridends, I hope you can learn more about C15H12O, If you have any questions, you can browse other blog as well. See you lster.

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An article Discovery of Keap1-Nrf2 small – molecule inhibitors from phytochemicals based on molecular docking WOS:000491684000040 published article about OXIDATIVE STRESS; IN-VITRO; SIGNALING PATHWAY; NRF2; ANTIOXIDANTS; INFLAMMATION; DERIVATIVES; EXPRESSION; FLAVONOIDS; 3D-QSAR in [Li, Maiquan; Jie, Fan; Wang, Mengmeng; Zhong, Yongheng; Chen, Qi; Lu, Baiyi] Zhejiang Univ, Natl Engn Lab Intelligent Food Technol & Equipmen, Zhejiang Key Lab Agrofood Proc,Fuli Inst Food Sci, Minist Agr,Coll Biosyst Engn & Food Sci,Key Lab A, Hangzhou 310058, Zhejiang, Peoples R China; [Li, Maiquan] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410208, Hunan, Peoples R China; [Huang, Weisu] Zhejiang Econ & Trade Polytech, Dept Appl Technol, Hangzhou 310018, Zhejiang, Peoples R China in 2019.0, Cited 31.0. HPLC of Formula: C15H12O. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Various phytochemicals have been reported to protect against oxidative stress. However, the mechanism underlying has not been systematically evaluated, which limited their application in disease treatment. Nuclear factor erythroid 2 – related factor 2 (Nrf2), a central transcription factor in oxidative stress response related to numerous diseases, is activated after dissociating from the cytoskeleton – anchored Kelch – like ECH – associated protein 1 (Keap1). The Keap1-Nrf2 protein-protein interaction has become an important drug target. This study was designed to clarify whether antioxidantive phytochemicals inhibit the Keap1-Nrf2 protein-protein interaction and activate the Nrf2-ARE signaling pathway efficiently. Molecular docking and 3D – QSAR were applied to evaluate the interaction effects between 178 antioxidant phytochemicals and the Nrf2 binding site in Keap1. The Nrf2 activation effect was tested on a H2O2 – induced oxidative – injured cell model. Results showed that the 178 phytochemicals could be divided into high – , medium – , and low – total -score groups depending on their binding affinity with Keap1, and the high total – score group consisted of 24 compounds with abundant oxygen or glycosides. Meanwhile, these compounds could bind with key amino acids in the structure of the Keap1 – Nrf2 interface. Compounds from high – total – score group show effective activation effects on Nrf2. In conclusion, phytochemicals showed high binding affinity with Keapi are promising new Nrf2 activators.

About Chalcone, If you have any questions, you can contact Li, MQ; Huang, WS; Jie, F; Wang, MM; Zhong, YH; Chen, Q; Lu, BY or concate me.. HPLC of Formula: C15H12O

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Safety of Chalcone. Recently I am researching about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; CYCLOOXYGENASE-2 COX-2; SUBSTANCE-P; DERIVATIVES; DESIGN; RISK; PROSTAGLANDINS; DENATURATION; CELECOXIB, Saw an article supported by the . Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Chandel, P; Kumar, A; Singla, N; Kumar, A; Singh, G; Gill, RK. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

In the present work, coumarin based pyrazolines (7a-g) have been synthesized and investigated for their in vitro and in vivo anti-inflammatory potential. Amongst the synthesized compounds, compounds 7a, 7d and 7f exhibited significant in vitro anti-inflammatory activity as compared to the standard etoricoxib. Keeping this in mind, in vivo investigations were carried out via carrageenan induced inflammation and acetic acid induced writhing models in male Wistar rats and compound 7a was found to possess appreciable anti-inflammatory and analgesic potential. The mode of action of compound 7a was also investigated by using substance P as the biomarker, which shows promising results. Further, the selectivity of the most active compound 7a against the cyclooxygenase enzyme was supported by molecular docking studies which reveal that compound 7a has greater binding affinity towards COX-2 over COX-1 and 5-LOX enzymes. In silico ADME analysis of compound 7a confirms the drug-like characteristics and the in vivo acute toxicity study showed the safety of the compound even up to a 2000 mg kg(-1) dose. Thus, compound 7a was identified as an effective anti-inflammatory agent, and can be explored for further analgesic/anti-inflammatory drug design and development.

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Authors Keskin, S in WILEY published article about ANTIOXIDANT ACTIVITY; PHENOLIC COMPOSITION; TURKISH PROPOLIS in [Keskin, Saban] Bilecik Seyh Edebali Univ, Vocat Sch Hlth Serv, Bilecik, Turkey in 2020, Cited 24. Recommanded Product: 94-41-7. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Orange peel oil contains high amount of d-limonene which is reported to have antidiabetic activity. Propolis contains many biologically active compounds like phenolic acids, flavonoids and terpenes. Because of its rich phenolic composition, antidiabetic activity of propolis has also been shown in literature. Consumption of raw propolis is limited because of its resinous nature. It should be extracted to convert it into consumable form. Ethanol is the most used solvent for this purpose. Ethanol is the limiting factor for propolis consumption either for religious concerns or being harmful for human health. There is an increasing need for new, compatible and healthier solvents for propolis extraction. This is the first paper describing the extraction of propolis with orange peel oil. 1:10 (g/v) ratio was used for extraction. Orange peel oil (OPO), orange peel oil propolis extract (OPOPE) and ethanol propolis extract (EPE) were separately analysed by using GC-MS technique. Total phenolic content of oil and propolis extract was also carried out. Inhibition of alpha-amylase from barley malt with new extract was also reported. It was found that OPOPE was rich in volatile compounds of propolis, phenolic acid derivatives and free fatty acids. It was observed that OPOPE showed higher inhibition on alpha-amylase enzyme (IC50 0.196 mg/mL). It can be concluded that orange peel oil could be used as solvent for preparing propolis extract. Propolis extract obtained with orange peel oil could also be used as complementary medicine for the treatment of type 2 diabetes.

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Rai, VK; Mahata, S; Bhardiya, SR; Shukla, P; Rai, A; Singh, M in [Rai, Vijai K.; Mahata, Suhasini; Bhardiya, Smita R.; Singh, Manorama] Guru Ghasidas Vishwavidyalaya, Dept Chem, Bilaspur 495009, Chhattisgarh, India; [Shukla, Prashant; Rai, Ankita] Jawaharlal Nehru Univ, Sch Phys Sci, New Delhi 110029, India published A novel carbocatalytic hydride transfer strategy for efficient reduction of structurally different aldehydes and ketones in water in 2019.0, Cited 52.0. SDS of cas: 94-41-7. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Reduced graphene oxide (rGO)-NaBH4 is reported as mild and efficient catalyst-system for chemo-/ regioselective reduction of structurally different aliphatic, aromatic as well as alpha,beta-unsaturated aldehydes and ketones in water. The rGO was prepared by reducing graphene oxide using Tulsi leaf extract as bio-reductant. Operational simplicity, ambient reaction condition, high yield of pure products (80-97%), no by-product formation, no use of column chromatography for purification are the salient features of the envisaged protocol. Furthermore, the recovered TRGO was recycled and reused for subsequent reductions up to five times without any loss in activity. (C) 2019 Published by Elsevier Ltd.

About Chalcone, If you have any questions, you can contact Rai, VK; Mahata, S; Bhardiya, SR; Shukla, P; Rai, A; Singh, M or concate me.. SDS of cas: 94-41-7

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Product Details of 94-41-7. Havrankova, E; Calkovska, N; Padrtova, T; Csollei, J; Opatrilova, R; Pazdera, P in [Havrankova, Eva; Calkovska, Nikola; Padrtova, Tereza; Csollei, Jozef; Opatrilova, Radka] Univ Vet & Pharmaceut Sci, Dept Chem Drugs, Fac Pharm, Brno 61242, Czech Republic; [Pazdera, Pavel] Masaryk Univ, Dept Chem, Ctr Synth Sustainable Condit & Their Management, Fac Sci, Brno 62500, Czech Republic published Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs in 2020.0, Cited 49.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

A series of 1,3,5-triazine analogues, incorporating aminobenzene sulfonamide, aminoalcohol/ phenol, piperazine, chalcone, or stilbene structural motifs, were evaluated as potential antioxidants. The compounds were prepared by using step-by-step nucleophilic substitution of chlorine atoms in starting 2,4,6-trichloro-1,3,5-triazine. Reactions were catalyzed by Cu(I)-supported on a weakly acidic resin. The radical scavenging activity was determined in terms of %inhibition activity and EC50, using the ABTS method. Trolox and ascorbic acid (ASA) were used as standards. In the lowest concentration 1 X 10(-4) M, the %inhibition activity values at 0 min were comparable with both standards at least for 10 compounds. After 60 min, compounds 5, 6, 13, and 25 showed nearly twice %inhibition (73.44-87.09%) in comparison with the standards (Trolox = 41.49%; ASA = 31.07%). Values of EC50 at 60 min (17.16-27.78 mu M) were 5 times lower for compounds 5, 6, 13, and 25 than EC50 of both standards (trolox = 178.33 mu M; ASA = 147.47 mu M). Values of EC50 correlated with %inhibition activity. Based on these results, the presented 1,3,5-triazine analogues have a high potential in the treatment of illnesses caused or related to oxidative stress.

Product Details of 94-41-7. Bye, fridends, I hope you can learn more about C15H12O, If you have any questions, you can browse other blog as well. See you lster.

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HPLC of Formula: C15H12O. Authors Gaur, PK in ELSEVIER published article about in [Gaur, Praveen Kumar] ITS Coll Pharm, Dept Pharmaceut, Meerut Rd, Murad Nagar 201206, Ghaziabad, India in 2021.0, Cited 50.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

The present study was planned to apply the nanotechnology to therapeutically proven flavonoid-rich fraction for obtaining a formulation with enhanced antihyperglycemic activity. The leaves were extracted in aqueous methanol and fractionated to yield a flavonoid-rich fraction. This fraction was formulated into an aqueous nanosuspension using PVA through the nanoprecipitation method. The developed formulations were characterized for physical parameters and optimum nanosuspension was evaluated against type 2 diabetes in high-fat diet-fed, streptozotocin-induced diabetic animals. The pharmacokinetic parameter and histopathology were assessed to determine the kinetic profile and tissue architectures post oral administration of selected nano suspension. The selected nanosuspension was also studied for stability under accelerated conditions. Flavonoidrich fraction was obtained using Kupchan partitioning. The developed nanosuspension PG-EA-NS-B showed optimum physical parameters. In hyperglycemia induced by streptozotocin, in high-fat diet-fed rats, it effectively restores the normal level of blood glucose in the first hour. The effects were comparable to standard Glibenclamide. In biochemical observations, PG-EA-NS-B, as well as PG-EA, showed beneficial effects on various hepatic and renal parameters. The pharmacokinetic parameters showed that nanosuspension enhances the absorption and decreases the metabolism of flavonoid actives. The selected nanosuspension and free flavonoid fraction showed rectification of histological changes. The nanosuspension was most stable in cool conditions. PVA based nanosuspensions can be a viable strategy for oral delivery of natural flavonoids, as it significantly affected the absorption and metabolism of flavonoids upon oral administration.

HPLC of Formula: C15H12O. Welcome to talk about 94-41-7, If you have any questions, you can contact Gaur, PK or send Email.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com