Tag: M.W=200-250

Recently I am researching about ANTIOXIDANT ACTIVITY; PHENOLIC COMPOSITION; TURKISH PROPOLIS, Saw an article supported by the . Published in WILEY in HOBOKEN ,Authors: Keskin, S. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone. Category: thiazolidines

Orange peel oil contains high amount of d-limonene which is reported to have antidiabetic activity. Propolis contains many biologically active compounds like phenolic acids, flavonoids and terpenes. Because of its rich phenolic composition, antidiabetic activity of propolis has also been shown in literature. Consumption of raw propolis is limited because of its resinous nature. It should be extracted to convert it into consumable form. Ethanol is the most used solvent for this purpose. Ethanol is the limiting factor for propolis consumption either for religious concerns or being harmful for human health. There is an increasing need for new, compatible and healthier solvents for propolis extraction. This is the first paper describing the extraction of propolis with orange peel oil. 1:10 (g/v) ratio was used for extraction. Orange peel oil (OPO), orange peel oil propolis extract (OPOPE) and ethanol propolis extract (EPE) were separately analysed by using GC-MS technique. Total phenolic content of oil and propolis extract was also carried out. Inhibition of alpha-amylase from barley malt with new extract was also reported. It was found that OPOPE was rich in volatile compounds of propolis, phenolic acid derivatives and free fatty acids. It was observed that OPOPE showed higher inhibition on alpha-amylase enzyme (IC50 0.196 mg/mL). It can be concluded that orange peel oil could be used as solvent for preparing propolis extract. Propolis extract obtained with orange peel oil could also be used as complementary medicine for the treatment of type 2 diabetes.

Category: thiazolidines. About Chalcone, If you have any questions, you can contact Keskin, S or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recommanded Product: 94-41-7. I found the field of Chemistry very interesting. Saw the article Synthesis of Trifluoromethyl- and Ester Group-Substituted alpha-Carbolines via Iron-Catalyzed Tandem Cyclization Reaction published in 2020.0, Reprint Addresses Wan, CF; Liu, JB (corresponding author), Jiangxi Normal Univ, Coll Chem & Chem Engn, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China.; Wan, CF; Liu, JB (corresponding author), Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China.; Liu, JB (corresponding author), Jiangxi Univ Sci & Technol, Sch Met & Chem Engn, Ganzhou 341000, Peoples R China.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone.

An efficient approach to prepare trifluoromethyl-alpha-carbolines and ester group-substituted alpha-carbolines via the tandem cyclization reaction of 2-(2-aminophenyl)acetonitriles and trifluoromethyl 1,3-diones or beta,gamma-unsaturated alpha-ketoesters was reported. The transformation proceeded smoothly in the presence of catalytic environmental-benign iron salts, which are used to prepare the desired products in moderate to good yields.

Recommanded Product: 94-41-7. About Chalcone, If you have any questions, you can contact Xu, YM; Chen, XQ; Gao, YQ; Yan, ZC; Wan, CF; Liu, JB; Wang, ZY or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Synthesis and Antitubercular Activity of 4,5-Disubstituted N-1-(5 ‘-deoxythymidin-5 ‘-yl)-1,2,3-triazoles published in 2020.0. HPLC of Formula: C15H12O, Reprint Addresses Prasad, AK (corresponding author), Univ Delhi, Dept Chem, Bioorgan Lab, Delhi 110007, India.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

Synthesis of fifteen C-4-aroyl-C-5-aryl-N-1-(5 ‘-deoxythymidin-5 ‘-yl)-1,2,3-triazoles have been reported starting from azidation of 5 ‘-p-toluenesulfonyloxythymidine followed by azide-alkene oxidative cycloaddition reaction of the resulted 5 ‘-azido-5 ‘-deoxythymidine with 1,3-diarylpropenones in dimethylformamide (DMF) in the presence of tetra-n-butylammonium hydrogen sulfate (n-Bu4N+HSO4-, TBAHS) as catalyst in 60 to 79% overall yields. Further, they were also synthesized by one pot sequential reaction of tosylated thymidine with sodium azide in DMF and then with 1,3-diarylpropenones in presence of n-Bu(4)N(+)HSO(4)(-)in superior yield of 70 to 95% than 60 to 79% in two step procedure. All fifteen synthesized compounds were screened for theirin vitroantiMycobacterium tuberculosisactivity against sensitive reference strain H37Rv and multi drug resistant (MDR) clinical isolate 591, and found to exhibit minimum inhibitory concentration (MIC) ranging from 2 to 15 mu g/mL, which was equivalent to the MIC of first line anti-tubercular drug streptomycin. All compounds qualify for their drug likeness when their physicochemical parameters were assessed using online MolSoft and Lipinski filter software, except their molecular weight. The cytotoxicity of potent compounds evaluated human monocytic cell line THP-1 by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was found to be less as compared to the first line drug, isoniazid.

HPLC of Formula: C15H12O. About Chalcone, If you have any questions, you can contact Kumar, R; Bimal, D; Kavita; Kumar, M; Mathur, D; Maity, J; Singh, SK; Thirumal, M; Prasad, AK or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Liu, YT; Luo, W; Wang, ZJ; Zhao, YX; Zhao, JJ; Xu, XJ; Wang, CJ; Li, P in [Liu, Yantao; Wang, Zhenjie; Zhao, Yuxin; Zhao, Jingjing; Xu, Xuejun; Li, Pan] Henan Univ, Coll Chem & Chem Engn, Inst Funct Organ Mol Engn, Kaifeng 475004, Peoples R China; [Luo, Wen; Wang, Chaojie; Li, Pan] Henan Univ, Key Lab Nat Med & Immunoengn, Kaifeng 475004, Peoples R China published Visible-Light Photoredox-Catalyzed Formal [5+1] Cycloaddition of N-Tosyl Vinylaziridines with Difluoroalkyl Halides in 2020.0, Cited 85.0. Product Details of 94-41-7. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

A visible-light photoredox-catalyzed formal [5 + 1] cycloaddition of N-tosyl vinylaziridines with difluoroalkyl halides as unique C1 synthons was developed. The procedure provides an efficient and practical method to synthesize diverse pyridines in moderate to good yields. The reaction underwent a radical-initiated kinetically controlled ring-opening of vinylaziridines and involved a key alpha,beta-unsaturated imine intermediate, followed by an E2 elimination, a 6 pi electrocyclization, and defluorinated aromatization.

Product Details of 94-41-7. About Chalcone, If you have any questions, you can contact Liu, YT; Luo, W; Wang, ZJ; Zhao, YX; Zhao, JJ; Xu, XJ; Wang, CJ; Li, P or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Lakshmi, SR; Singh, V; Chowhan, LR in ROYAL SOC CHEMISTRY published article about FLUORESCENCE CHEMOSENSORS; DIRECT AMIDATION; FACILE SYNTHESIS; RAPID SYNTHESIS; DERIVATIVES; INHIBITORS; MCI-186; ACIDS; DISCOVERY; ISCHEMIA in [Lakshmi, Shanta Raj; Singh, Vipin; Chowhan, L. Raju] Cent Univ Gujarat, Ctr Appl Chem, Sect 30, Gandhinagar 382030, India in 2020.0, Cited 61.0. Formula: C15H12O. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Tandem conjugate addition, decarboxylation and esterification/amidation of coumarin 3-carboxylic acid derivatives with pyrazolones have been developed. The reactions were performed with coumarin 3-carboxylic acid/esters and pyrazolone in alcohol as a solvent to afford the corresponding pyrazolyl 2-hydroxy phenylpropionate derivatives. Amines and green solvents were employed for amidation in the addition reaction. The methodology has advantages such as excellent yields, a broad substrate scope, catalyst-free, easy purification by simple filtration without any workup, mild conditions and does not require any organic solvents, ligands, base or any additives. This is a green and general synthetic protocol, which could be applicable for the synthesis of substituted pyrazolyl phenyl propionate/amide derivatives. This approach demonstrates the importance of the coumarin 3-carboxylic acid/ester core structure for Michael addition.

Formula: C15H12O. About Chalcone, If you have any questions, you can contact Lakshmi, SR; Singh, V; Chowhan, LR or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Dehydrative C- and S-Alkylation: Access to Highly Substituted 1-Sulfonylpropanes WOS:000466161500019 published article about FRIEDEL-CRAFTS REACTIONS; ALLYLIC ALCOHOLS; NUCLEOPHILIC SUBSTITUTIONS; BENZYLIC ALCOHOLS; ALPHA-ALKYLATION; BOND ACTIVATION; METAL; BENZYLATION; GENERATION; INDOLES in [Aegurla, Balakrishna; Peddinti, Rama Krishna] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, Uttarakhand, India in 2019.0, Cited 71.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Recommanded Product: Chalcone

A dehydrative C- and S-alkylation procedure by nucleophilic substitution of gamma-hydroxysufones with arenes and thiophenols is reported. This study represents an elegant and ecological concept to construct C-C and C-S bonds leading to unsymmetrical 1,1- and 3,3-branched propanes. The gamma-hydroxysufones underwent BF3 center dot OEt2-mediated dehydrative arylation and thiolation at room temperature and elimination at 40 degrees C. The nucleophile attack occurred on the less hindered side of a planar benzylic carbocation to furnish the title compounds with good diastereoselectivity.

About Chalcone, If you have any questions, you can contact Aegurla, B; Peddinti, RK or concate me.. Recommanded Product: Chalcone

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Hejazifar, M; Palvolgyi, AM; Bitai, J; Lanaridi, O; Bica-Schroder, K in AMER CHEMICAL SOC published article about AROMATIC KETONES; TRANSFER REDUCTION; CHIRAL LIGANDS; WATER; CATALYST; COMPLEXES; RUTHENIUM; IMINES; RESOLUTION in [Hejazifar, Mahtab; Palvoelgyi, Adam Mark; Bitai, Jacqueline; Lanaridi, Olga; Bica-Schroeder, Katharina] TU Wien, Inst Appl Synthet Chem, Getreidemarkt 9-163, A-1060 Vienna, Austria in 2019.0, Cited 57.0. Application In Synthesis of Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

A thermomorphic ionic-liquid-based microemulsion system was successfully applied for the Ru-catalyzed asymmetric transfer hydrogenation of ketones. On the basis of the temperature-dependent multiphase behavior of the targeted microemulsion, simple product separation as well as catalyst recycling could be realized. The use of water-soluble ligands improved the immobilization of the catalyst in the microemulsion phase and significantly decreased the catalyst leaching into the organic layer upon extraction of the product. Eventually, the optimized microemulsion system could be applied to a wide range of aromatic ketones that were reduced with good isolated yields (up to 98%) and enantioselectivities (up to 97%), while aliphatic ketones were less successful.

Application In Synthesis of Chalcone. About Chalcone, If you have any questions, you can contact Hejazifar, M; Palvolgyi, AM; Bitai, J; Lanaridi, O; Bica-Schroder, K or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Screening of chalcone analogs with anti-depressant, anti-inflammatory, analgesic, and COX-2-inhibiting effects WOS:000526087400021 published article about ANTIDEPRESSANT; CYTOTOXICITY; FLAVONOIDS; INHIBITORS; ALKALOIDS; QUINOLONE in [Huang, Zhe-Hao; Li, Zhao-Hui] Jilin Univ, Dept Neurosurg, China Japan Union Hosp, Changchun 130033, Peoples R China; [Yin, Li-Quan] Jilin Univ, Rehabil Med Dept, China Japan Union Hosp, Changchun 130033, Peoples R China; [Guan, Li-Ping] Zhejiang Ocean Univ, Food & Pharm Coll, Zhoushan 316022, Peoples R China; [Tan, Cheng] Jilin Univ, Dept Neurol, China Japan Union Hosp, Changchun 130033, Peoples R China in 2020.0, Cited 31.0. Recommanded Product: Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

A group of 2-methyl-4-phenylquinoline-chalcone analogs (2a-2x) was synthesized and investigated for anti-depressant, anti-inflammatory, and analgesic effects as cyclooxygenase-2 inhibitors. Pharmacological experiments identified 24 analogs that exhibited anti-depressant, anti-inflammatory, and analgesic activities. In particular, compounds 2c, 2k, and 2w markedly shortened immobility times and exhibited the most anti-depressant activity. In addition, the mechanisms of action of the analogs 2c, 2k, and 2w were likely related to increased serotonin levels in the central nervous system. Compounds 2c, 2k, and 2w displayed reasonable cyclooxygenase-2 inhibitory effects (IC50 values from 0.21 to 0.29 mu mol/L) similar to celecoxib (IC50: 0.19 mu mol/L) in vitro. A molecular docking study of compound 2k also was conducted.

Recommanded Product: Chalcone. About Chalcone, If you have any questions, you can contact Huang, ZH; Yin, LQ; Guan, LP; Li, ZH; Tan, C or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chang, GL; Zhang, P; Yang, WJ; Xie, SQ; Sun, HJ; Li, XY; Fuhr, O; Fenske, D in [Chang, Guoliang; Zhang, Peng; Yang, Wenjing; Xie, Shangqing; Sun, Hongjian; Li, Xiaoyan] Shandong Univ, Key Lab Special Funct Aggregated Mat, Sch Chem & Chem Engn, Minist Educ, Shanda Nanlu 27, Jinan 250100, Peoples R China; [Fuhr, Olaf; Fenske, Dieter] Karlsruher Inst Technol KIT, Inst Nanotechnol INT, Karlsruher Nanomicrofacil KNMF, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany published PyridineN-oxide promoted hydrosilylation of carbonyl compounds catalyzed by [PSiP]-pincer iron hydrides in 2020.0, Cited 29.0. Name: Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Five [PSiP]-pincer iron hydrides1-5, [(2-Ph2PC6H4)(2)HSiFe(H)(PMe3)(2)(1), (2-Ph2PC6H4)(2)MeSiFe(H)(PMe3)(2)(2), (2-Ph2PC6H4)(2)PhSiFe(H)(PMe3)(2)(3), (2-(iPr)(2)PC6H4)(2)HSiFe(H)(PMe3) (4), and (2-(iPr)(2)PC6H4)(2)MeSiFe(H)(PMe3)(2)(5)], were used as catalysts to study the effects of pyridine N-oxide and the electronic properties of [PSiP]-ligands on the catalytic hydrosilylation of carbonyl compounds. It was proved for the first time that this catalytic process could be promoted with pyridine N-oxide as the initiator at 30 degrees C because the addition of pyridineN-oxide is beneficial for the formation of an unsaturated hydrido iron complex, which is the key intermediate in the catalytic mechanism. Complex 4 as the best catalyst shows excellent catalytic performance. Among the five complexes, complex 3 was new and the molecular structure of complex 3 was determined by single crystal X-ray diffraction. A proposed mechanism was discussed.

Name: Chalcone. About Chalcone, If you have any questions, you can contact Chang, GL; Zhang, P; Yang, WJ; Xie, SQ; Sun, HJ; Li, XY; Fuhr, O; Fenske, D or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Luo, NH; Zhong, YH; Wen, HL; Shui, HL; Luo, RS in WILEY-V C H VERLAG GMBH published article about in [Luo, Nianhua; Zhong, Yuhong; Wen, Huiling; Shui, Hongling; Luo, Renshi] Gannan Med Univ, Sch Pharmaceut Sci, Ganzhou 341000, Jiangxi, Peoples R China in 2021, Cited 94. SDS of cas: 94-41-7. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Ketones are of great importance in synthesis, biology, and pharmaceuticals. This paper reports an iridium complexes-catalyzed cross-coupling of alcohols via hydrogen borrowing, affording a series of alpha-alkylated ketones in high yield (86 %-95 %) and chemoselectivities (>99 : 1). This methodology has the advantages of low catalyst loading (0.1 mol%) and environmentally benign water as the solvent. Studies have shown the amount of base has a great impact on chemoselectivities. Meanwhile, deuteration experiments show water plays an important role in accelerating the reduction of the unsaturated ketones intermediates. Remarkably, a gram-scale experiment demonstrates this methodology of iridium-catalyzed cross-coupling of alcohols has potential application in the practical synthesis of alpha-alkylated ketones.

SDS of cas: 94-41-7. About Chalcone, If you have any questions, you can contact Luo, NH; Zhong, YH; Wen, HL; Shui, HL; Luo, RS or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com