Tag: M.W:100-200

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Heterocyclic Chemistry called Photophysical properties of a C6 hydrocarbon-linked porphyrin dimer, Author is Kozyrev, Andrei N.; Mironov, Andrei F.; Davila, Jorge; Harriman, Anthony, which mentions a compound: 2199-44-2, SMILESS is O=C(C1=C(C)C=C(C)N1)OCC, Molecular C9H13NO2, Formula: C9H13NO2.

The porphyrin dimer I and its Zn complex were prepared Fluorescence quantum yields and excited singlet and triplet state lifetimes, recorded for the dimers and the corresponding monomer species, suggest that the dimeric porphyrins exist in solution in both open and closed conformations. The open conformations retain photophys. properties similar to those of the monomerics but the closed conformations do not fluoresce.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A novel route to certain 2-pyrrolecarboxylic esters and nitriles, published in 1955, which mentions a compound: 2199-44-2, Name is Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, Molecular C9H13NO2, SDS of cas: 2199-44-2.

HON:C(CO2Et)2 (I) underwent reduction and condensation with certain β-diketones and a β-oxo aldehyde to give 2-pyrrolecarboxylic esters. Similarly, HON:C(CN)CO2Et (II) and certain β-diketones afforded 2-pyrrolecarbonitriles. The method has been applied to the synthesis of 5 previously known pyrroles. This synthetic approach constitutes the most direct route to 4 of these 5 pyrroles. A sixth and previously unreported pyrrole, 3,5-dimethyl-2-pyrrolecarbonitrile (III), also has been prepared by this method. Ac2CH2 (5.00 g.) in 26 cc. glacial AcOH heated with vigorous stirring at 80° with 13 g. NaOAc and 11 g. Zn dust, the mixture then treated with 9.47 g. I in 12 cc. AcOH and 5 cc. H2O dropwise at 95-105° during 30-40 min., heated 20 min. at 100-5°, poured with stirring into 170 cc. ice water, and refrigerated, the precipitate washed with H2O, pressed dry, dissolved in 50 cc. boiling EtOH, and filtered hot, the filtrate concentrated to 30 cc., poured into 85 cc. ice water, and refrigerated, and the crystalline deposit dried in vacuo (5.03 g.), and recrystallized twice from 95% EtOH yielded 2-carbethoxy-3,5-dimethylpyrrole (IV), m. 124-4.5°. I and Ac2CHEt (50 millimole each), b23-3.5 79-83.5°, gave by the same procedure 6.36 g. 4-Et derivative of IV, m. 90-1° (from 95% EtOH). I and Ac2CH(CH2)2CO2H (50 millimoles) treated in the same manner, the reaction mixture treated with 5 cc. concentrated HCl, and the crude product (7.08 g.) recrystallized from boiling C6H6 gave 5-carbethoxy-2,4-dimethyl-3-pyrrolepropionic acid, m. 154-6°. NaOAc (7.9 g.) added with stirring to 29 cc. glacial AcOH at 85°, the mixture treated with 7.00 g. AcCHMeCHO, 9.48 g. I, and 12 cc. glacial AcOH in 5 cc. H2O, followed by 11 g. Zn dust at 95-105°, stirred 20 min., poured into 170 cc. ice water, and refrigerated, and the deposit dissolved in 10 cc. boiling EtOH and filtered, the filtrate poured into 20 cc. ice water, and the precipitate (2.49 g.) recrystallized from 95% EtOH and then twice from isoöctane gave 2-carbethoxy-3,4-dimethylpyrrole (V), m. 75-6.5°. V heated briefly in EtOH with excess 40% aqueous CH2O and a few drops concentrated HCl yielded 5,5′-methylenebis(2-carbethoxy-3,4-dimethylpyrrole), m. 202-3°. II and Ac2CH2 (50 millimoles each) treated by the usual procedure, the crude product containing the Zn dust dissolved in 25 cc. boiling 95% EtOH, and the filtrate poured into 75 cc. ice water yielded 2.48 g. IV, m. 24-5° (recrystallized from EtOH and sublimed). Glacial AcOH (26 cc.) and 5.00 g. Ac2CH2 heated to 80°, the mixture treated consecutively with 13 g. NaOAc, 7.11 g. II, and 12 cc. AcOH in 5 cc. H2O, heated to 95°, treated during 20-5 min. with 11 g. Zn dust at 95-105°, stirred 20 min., and poured into ice water, the precipitate refrigerated, filtered off, dissolved in 15 cc. boiling EtOH, and filtered, the filtrate stirred into 30 cc. ice water and refrigerated, and the crude precipitate (2.10 g.) recrystallized twice from isoöctane yielded III, m. 75-6.5°. II and Ac2CHEt gave similarly 45% crude 4-Et derivative of III, m. 135-6°.

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Recommanded Product: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, is researched, Molecular C9H13NO2, CAS is 2199-44-2, about Nuclear magnetic resonance study of carbethoxypyrroles. Author is Roomi, Mohammad W.; Dugas, H..

The chem. shifts and the ring proton coupling constants of various substituted carbethoxypyrroles are reported. The electron-withdrawing effect of the carbethoxy groups shifts the resonances of the ring substituents to low field while the inductive and mesomeric effects of the Me groups shift the resonances to higher field. The deshielding effect is more pronounced with 2-carbethoxypyrroles than for 3-carbethoxypyrroles. The ring proton spin-spin coupling constants depend on the nature of substituents and increase with the electronegativity of the substituents. In some cases, long-range coupling between the Me side-chain protons and ring protons was observed.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate( cas:2199-44-2 ) is researched.Product Details of 2199-44-2.Sundukova, T. A.; Vasilevskii, S. F.; Shvartsberg, M. S.; Kotlyarevskii, I. L. published the article 《Acetylene condensation in a series of pyrroles》 about this compound( cas:2199-44-2 ) in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya. Keywords: acetylene condensation pyrrolecarboxylate. Let’s learn more about this compound (cas:2199-44-2).

Condensation of Et 4-iodo-3,5-dimethylpyrrole-2-carboxylate with HCCR(R = Ph, morpholinomethyl) in Et2NH in the presence of Pd (PPh3)2Cl2 and CuI gave ethynylpyrroles I in 64 and 68% yield, resp. Similar reaction with HOCMe2CCH gave the deiodinated product in 18% yield. Treatment of II (R = I) with CuCCPh in pyridine-DMF at reflux gave 78.0% II (R = CCPh). Deiodination of III (R = I) (IV) was easier than with the 4-iodo-2-carboxylate derivative but more difficult than II (R = I). In the presence of Pd complex catalyst condensation of IV and PhCCH gave concurrent redn and substitution.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and spectral properties of helicate of cobalt(II) with Bis(1,2,3,7,9-pentamethyldipyrrolylmethen-3-yl)methane, published in 2011-01-31, which mentions a compound: 2199-44-2, mainly applied to dinuclear cobalt bisdipyrrolylmethenylmethane complex preparation, Electric Literature of C9H13NO2.

Ligand bis(1,2,3,7,9-pentamethyldipyrrolylmethen-8-yl)methane (H2L) was synthesized as a hydrobromide salt (H2L·2HBr) (1). Reaction of cobalt(II) acetate tetrahydrate with compound (1) in a chloroform/methanol mixture in the presence of triethylamine afforded a binuclear homoleptic double-helical complex [Co2(L)2] (2). UV absorption, 13C and 1H NMR spectra were used to characterize the compounds 1 and 2.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called tert-Butylpyrroles, published in 1970, which mentions a compound: 2199-44-2, Name is Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, Molecular C9H13NO2, Recommanded Product: 2199-44-2.

Reaction of 3-(R-substituted)-2,4-dimethylpyrroles (R = CO2Et or Ac) with tert-BuOAc in the presence of strong acids, e.g. H2SO4, HClO4, or HI gave 12-30% corresponding 5-tert-butyl compounds (I). Treatment of I (R = CO2Et) with H3PO4 gave 43% I (R = H). Similar reactions were performed with 5-(ethoxycarbonyl)-2,4-dimethylpyrrole.

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Product Details of 2199-44-2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, is researched, Molecular C9H13NO2, CAS is 2199-44-2, about Dithiocarboxylic acids of pyrroles. II. Friedel-Crafts reactions with carbon disulfide. Author is Treibs, Alfred; Friess, Raimund.

Reaction of 2,4-dimethyl-5-(ethoxycarbonyl)pyrrole (I) with AlCl3 in CS2 gave 10% 3-(dithiocarboxy) derivative (II) of I. The same reactions in the presence of ClCO2Et gave the Et ester of II. 2-Methyl-3-(ethoxycarbonyl)pyrrole-5-dithiocarboxylic acid was obtained in 10% yield from 2-methyl-3-(ethoxycarbonyl)pyrrole with AlCl3 and CS2. These reactions show CS2 was not an indifferent solvent in Friedel-Crafts reactions.

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SDS of cas: 15965-55-6. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Chloro-7-nitro-1H-benzo[d]imidazole, is researched, Molecular C7H4ClN3O2, CAS is 15965-55-6, about Benzimidazoles. II. Effect of benzene nucleus substituents on the nuclopphilic reactivity of some 2-chloro-benzimidazoles. Author is Ricci, Alfredo; Vivarelli, Piero.

cf. CA 67: 64300p. An equimol. mixture of 4,2-R(H2N)C6H3NH2.2HCl, or 3,2-R(H2N)C6H3NH2.2HCl and urea, heated 20 min. at 160-80°, the reaction mixture extracted with hot 10% NaOH and the alk. solution acidified with HCl, precipitated known 5(6)-substituted- or 4(7)-substituted-2-benzimidazolones, resp., which (0.01 mole) with 0.07 mole POCl3 and a few drops of concentrated HCl, heated 3-4 hrs. at 160-70° in a sealed tube yielded the following I (R, m.p., and % yield given): 5(6)-NO2, 222-3°, -; 5(6)-Cl, 207-8°, 70; 5(6)-Me, 185-6°, 72; 5(6)-MeO, 170-1°, 40; 4(7)-NO2, 196-7°, 40; 4(7)-Cl, 187-8°, 70; 4(7)-Me, 141-2°, 50; 4(7)-MeO, 151-2°, 55. Kinetic studies on the nucleophilic reactivity of I, carried out with piperidine at 100°, indicated that the 2-Cl mobility increases when R is electron-withdrawing, and decreases when R is electron donor. A linear correlation was also found for the effect of the substituents on the reaction center with σmeta + σpara for the position 5(6) and σortho + σmeta for the 4(7)-position, resp.

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Related Products of 2199-44-2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, is researched, Molecular C9H13NO2, CAS is 2199-44-2, about Direct synthesis of β-alkenylpyrroles by Pd(II)-catalyzed addition of pyrroles to alkynoates. Author is Oyamada, Juzo; Lu, Wenjun; Jia, Chengguo; Kitamura, Tsugio; Fujiwara, Yuzo.

β-Alkenylpyrroles were prepared directly by Pd(II)-catalyzed addition of pyrroles to alkynoates at room temperature This procedure was applied to direct synthesis of a β-alkenylpyrrole, the pyrrole fragment of hemin.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, is researched, Molecular C9H13NO2, CAS is 2199-44-2, about Synthesis and spectral properties of 3,3′-bis(dipyrrolylmethene).Safety of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate.

Bis(2,4,7,8,9-pentamethyldipyrrolylmethen-3-yl)(4′-methoxyphenyl)methane dihydrobromide was synthesized and its spectral properties were studied. The basicity of the ligand 3,3′-bis-(dipyrrolylmethene) decreases upon insertion of the methoxyphenyl group in the 3,3′-spacer.

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