Tag: M.W:100-200

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Preliminary work to the ring syntheses of porphyrins, etc. III. Several pyrrole compounds with amino groups and unsaturated side chains》. Authors are Fischer, H.; Zeile, Karl.The article about the compound:Ethyl 3,5-Dimethyl-2-pyrrolecarboxylatecas:2199-44-2,SMILESS:O=C(C1=C(C)C=C(C)N1)OCC).HPLC of Formula: 2199-44-2. Through the article, more information about this compound (cas:2199-44-2) is conveyed.

cf. C. A. 24, 5302. 2,4-Dimethyl-3-amino-5-carbethoxypyrrole (I) yields an Ac derivative, m. 201° (60% yield). With iso-AmNO2, I gives 90% of the diazonium chloride, decomposes at 173°; it is not completely decomposed by boiling with H2O for 1 hr.; continued boiling, especially with Cu powder, gives 2,4-dimethyl-5-carbethoxypyrrole, m. 125°. Hydrolysis of I with 10% NaOH gives 2,4-dimethyl-3-amino-5 carboxypyrrole (II), which begins to split off CO2 at 75°; Ac derivative, m. 203° (decomposition). 2,4-Dimethyl-3-aminopyrrole, m. 127°, results in about 50% yield by warming the moist II at 75°; Ac derivative, m. 205°. The bromination product of the Ac derivative of I, heated with H2O, gives nearly quant. bis(3-acetylamino-4-methyl-5-carbethoxy-2-dipyrryl)methane, m. 251°, crystallizing in different forms from EtOH, Ac2O and dilute AcOH. With HCO2H and Fe powder, this yields an amorphous 1,4,5,8-tetramethyl-2,3,6,7 tetraacetylaminoporphin. II, HCO2H and HBr, heated 2-3 min., give (2,4-di-methyl-3-aminopyrryl)-2′,4′-dimethyl-3′-aminopyrrolenyl)methene tri-HBr salt, decomps over 280°; from H2O it seps. as violet crystals, from HBr in yellow-red prisms; AcONa gives the mono-HBr salt, dark violet needles, m. 234°. 2,4-Dimethyl-3-(β-carboxy-vinyl)-5-carbethoxypyrrole (III) and NaOH with a little H2O, heated over a free flame for 2 hrs. and then dry-distilled, give dimethylpyrrole and (2,4-dimethylpyrryl)(2′,4′-dimethylpyrrolenyl)methene. MeNO2 adds to 2,4-dimethyl-3-(β-nitrovinyl)-5-carbethoxypyrrole, giving the compound C12H17O6N3, m. 180°. 2,4-Dimethyl-3-(β-dicyano-vinyl)-5-carbethoxypyrrole (IV) and Br give a perbromide, golden yellow, decomposed by H2O to a 2-bromomethyl derivative, m. 258°. IV, MeOH and Br give the 2-carbomethoxy derivative, m. 187°; saponification with 0.1 N NaOH by heating 12 hrs. at 85° gives 2.5-dicarboxy-3-formyl-4-methylpyrrole, does not m. 360°; the di-Me ester m. 180° (oxime, m. 221°; semicarbazone, m. 247°). IV and SO2Cl2 in Et2O, followed by hydrolysis with H2O, give the 2-carboxy derivative, does not m. 360°; similarly III gives the 2-carboxy derivative, m. 241°; the free acid has no m. p. The Me ester of III m. 150°. 2,4-Dimethyl-3-formyl-5-carbethoxypyrrole and SO2Cl2 give the 2-carboxy-3-chloro derivative, m. 260°. 2,4-Di-methyl-3,5-diformylpyrrole (V) and 2,4-dimethyl-3-acetylpyrrole with HBr-EtOH give (2,4-dimethyl-3-formylpyrryl)(2′,4′-dimethyl-3′-acetylpyrrolenyl)methene, m. 210°. V and cryptopyrrole give with HBr 5,5′,3,3′-tetramethyl-4-ethyl-4′-formylpyrromethene-HBr, thick prisms. 2,4-Dimethyl-5-carbethoxy-3-thioformylpyrrole, for which a method of preparation is given, gives with SO2Cl2 and H2O 4-methyl-3-formyl-2-carbethoxy-5-carboxylic acid-pyrrole, m. 169°; phenylhydrazone, yellow, m. 235°.

There are many compounds similar to this compound(2199-44-2)HPLC of Formula: 2199-44-2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15965-55-6, is researched, SMILESS is O=[N+](C1=C2NC(Cl)=NC2=CC=C1)[O-], Molecular C7H4ClN3O2Journal, Khimiko-Farmatsevticheskii Zhurnal called Synthesis and biological activity of 5,6-dinitro derivatives of benzimidazole, Author is Chernova, E. Yu.; Mokrushina, G. A.; Chupakhin, O. N.; Kotovskaya, S. K.; Il’enko, V. I.; Andreeva, O. T.; Boreko, E. I.; Vladyko, G. V.; Korobchenko, L. V., the main research direction is virucide dinitrobenzimidazole; benzimidazole dinitro virucide bactericide; bactericide dinitrobenzimidazole.SDS of cas: 15965-55-6.

The title compounds I [R = H·HCl, Me; R1 = NH2NH, amino, azolyl (II)] were prepared from chlorobenzimidazoles I [R1 = Cl (III)]. III in turn, were prepared by the nitration of 2-chlorobenzimidazole. The antiviral and antimicrobial activity of II were examined

Here is just a brief introduction to this compound(15965-55-6)SDS of cas: 15965-55-6, more information about the compound(2-Chloro-7-nitro-1H-benzo[d]imidazole) is in the article, you can click the link below.

Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2199-44-2, is researched, Molecular C9H13NO2, about New method for synthesis of (ω-chloroalkyl)pyrroles, the main research direction is chloroalkylpyrrolecarboxylate preparation; pyrrole chloroalkyl derivative preparation.Category: thiazolidine.

Et 4-(ω-chloroalkyl)-3,5-dimethyl-1H-pyrrole-2-carboxylates (alkyl = Et, Pr, butyl) were prepared in >96% yields from Et 4-(ω-chloroacyl)-3,5-dimethyl-1H-pyrrole-2-carboxylates by treatment with NaBH4 followed by BF3·Et2O in THF. The ω-chloroacyl derivatives were prepared from 2-(ethoxycarbonyl)-3,5-dimethylpyrrole (1) by Friedel-Crafts reaction in >91% yields. 1 Was prepared in one step from 2,4-pentanedione and di-Et aminomalonate or di-Et oximinomalonate according to literature methods.

Here is just a brief introduction to this compound(2199-44-2)Category: thiazolidine, more information about the compound(Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate) is in the article, you can click the link below.

Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate( cas:2199-44-2 ) is researched.HPLC of Formula: 2199-44-2.Takaya, Hikaru; Kojima, Sachiko; Murahashi, Shun-Ichi published the article 《Rhodium Complex-Catalyzed Reaction of Isonitriles with Carbonyl Compounds: Catalytic Synthesis of Pyrroles》 about this compound( cas:2199-44-2 ) in Organic Letters. Keywords: isonitrile reaction ketone rhodium catalyst; pyrrole preparation isonitrile reaction ketone rhodium catalyst. Let’s learn more about this compound (cas:2199-44-2).

Low-valent rhodium complexes are efficient catalysts for the activation of α-C-H bond of isonitriles. Addition of isonitriles to carbonyl compounds proceeds under mild and neutral conditions to give the corresponding α,β-unsaturated formamides. Catalytic synthesis of pyrroles can be performed by cyclocondensation of isonitriles with 1,3-dicarbonyl compounds Et 3,4,5-trimethyl-2-pyrrolecarboxylate was obtained in 68% yield and converted to octamethylporphyrin by a standard method.

Here is just a brief introduction to this compound(2199-44-2)HPLC of Formula: 2199-44-2, more information about the compound(Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate) is in the article, you can click the link below.

Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Some transformations of 2,4-dimethylpyrrole》. Authors are Fischer, Hans; Weiss, Bernhard; Schubert, Max.The article about the compound:Ethyl 3,5-Dimethyl-2-pyrrolecarboxylatecas:2199-44-2,SMILESS:O=C(C1=C(C)C=C(C)N1)OCC).Formula: C9H13NO2. Through the article, more information about this compound (cas:2199-44-2) is conveyed.

From 0.9 g. 2,4-dimethylpyrrole (I) and 0.8 g. MeCN in cold Et2O saturated with dry HCl and allowed to stand 1 day is obtained 0.7 g. of the ketimine, m. 100°, sublimes 100° (HCl salt, green needles), of 2,4-dimethyl-5-acetylpyrrole (II). The ketimine is reduced by H and Pt sponge in alc. to I and when boiled with H2O to disappearance of the NH3 odor, 0.7 g. of it gives 0.3 g. II, m. 121°. 2,4-Dimethyl-5-chloroacetylpyrrole (0.9 g. from 1 g. I and 1 g. MeCN in cold Et2O saturated with dry HCl and allowed to stand 0.5 hr. in ice), m. 143°, gives in alc. with 30% NHMe2 after 0.5 hr. at 100° the 5-dimethylaminoacetyl derivative, m. 110°, while 0.5 g. boiled 0.5 min. in alc. with 40% HCHO and a few drops concentrated HCl yields 0.4 g. bis-[2,4-dimethyl-5-chloroacetylpyrryl]methane, m. 258°, which with NHMe2 in alc. gives the bis-5-dimethylaminoacetyl derivative m. 170°. I (1 g.) boiled up several times with 2 g. of 90% HCO2H and 10 drops of 20% HClO4 and allowed to stand 1 day gives 0.5 g. of the perchlorate, becomes discolored 200°, does not m. 260°, of bis-[2,4-dimethyl-pyrryl]methene, yellow, m. 117°. 2,4-Dimethyl-5-carbethoxypyrrole (III), obtained in 60-70% yield from I and EtMgBr and subsequent treatment with ClCO2Et, m. 125°, gives a positive Ehrlich aldehyde reaction in the cold, is hydrolyzed by boiling 50% KOH to the free acid, m. 136°, also obtained from the above Grignard compound with CO2. 2,4-Dimethyl-5-carbethoxypyrrole-3-aldehyde (IV). obtained in 85% yield from III and HCN in cold Et2O saturated with dry HCl and subsequent decomposition of the resulting imide chloride with hot H2O, m. 145°, gives a faint Ehrlich aldehyde reaction in the cold, more strongly on heating; 3 g. heated with 1:1 KOH until completely dissolved (about 15 min.) gives 2.2 g. of the free 5-carboxyaldehyde, m. 230°, which on distillation in vacuo yields 2,4-dimethylpyrrole-3-aldehyde, m. 126°, gives a positive aldehyde reaction even in the cold. Phenylhydrazone of IV, m. 204°. Azlactone, C19H18O4N2 (1.3 g. from 1.2 g. IV, 1.8 g. hippuric acid, 2.2 g. NaOAc and 20 cc. Ac2O heated 35 min. on the H2O bath), m. 232°. Oxime, m. 196-7°, converted by boiling NaOAc-Ac2O into the nitrile, C10H12O2N2, m. 171°. Semicarbazone, m. 285° (decomposition), converted by Na in alc. after 8 hrs. at 160-70° into 2,3,4-trimethylpyrrole. 2,4-Dimethyl-5-carbethoxy-3-chloroacetylpyrrole, from III and ClCH2CN, m. 163°, gives a faint positive Ehrlich reaction on heating, is highly sternutatory when powdered, gives in boiling alc. with aqueous KCN the 3-cyanoacetyl derivative, m. 172-3°.

Here is just a brief introduction to this compound(2199-44-2)Formula: C9H13NO2, more information about the compound(Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate) is in the article, you can click the link below.

Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Molecular compounds of pyrroles》. Authors are Dezelic, Mladen.The article about the compound:Ethyl 3,5-Dimethyl-2-pyrrolecarboxylatecas:2199-44-2,SMILESS:O=C(C1=C(C)C=C(C)N1)OCC).Formula: C9H13NO2. Through the article, more information about this compound (cas:2199-44-2) is conveyed.

The following data were obtained by means of f.-p. determinations In each case the eutectic point is given in mole % of the 2nd component; T. P. = transition point. 2,4-Dimethyl-3-acetyl-5-carbethoxypyrrole (I): AcOH, no solid compound; succinic acid (II), 25%, 126.5°; BzCH (III), 63% 87.5°; ClCH2CO2H (IV), 91%, 52° (T. P., 55%, 85.3°); PhOH (V), 90%, 27° (T. P. 55%, 93°), salicylic acid (VI), 58%, 106° (2 T. P., 38%, 113°, and 50%, 107°); therefore 2 compounds 2I.VI and I.VI; picric acid (VII), 60%, 94° (T. P., 50%, 97.8°); o-C6H4(OH)2 (VIII), 57%, 71° (T. P., 41%, 108.5°); m-C6H4(OH)2 (IX), 2 eutectics, 19%, 132.5°, and 78%, 44° (maximum at 33.3% and 139°); p-C6H4-(OH)2 (X), 2 eutectics, 10%, 138.2° and 62%, 135° (maximum at 33.3%, 153°). 2,4-Dimethyl-5-carbethoxypyrrole (XI): IV, 80%, 49°; V, 86%, 23°; VI, 40%, 94.5°; VIII, 66%, 71°; IX, 56.5%, 74.5°; X, 32%, 106°; VII, 66%, 94° (T. P., 33.3%, 100°; compound, 2XI.VII). 2,4-Dimethyl-5-carbethoxypyrrole-3-aldehyde (XII): IV, 86%, 51° (T. P., 60%, 74.5°; compound, XII.IV); III, maximum at 50% and 135°, 2 eutectics; VII, 60%, 95.5° (T. P., 50%, 97°); VIII forms the compound XII.VIII, m. 114° (2 eutectics); X forms the compound 2XII.X, m. 142° (2 eutectics). 2,5-Dimethyl-3-carbethoxypyrrole-4-aldehyde (XIII):VIII, 67%, 56°; IX, 61%, 80°, compound XIII.IX, m. 98°; compound XIII.X, m. 117.5°; VI forms 2 compounds, 2XIII.VI, and XIII.VI, eutectics 42%, 109° and 57.5%, 109° (T. P., 36%, 111°).

I hope my short article helps more people learn about this compound(Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate)Formula: C9H13NO2. Apart from the compound(2199-44-2), you can read my other articles to know other related compounds.

Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Safety of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, is researched, Molecular C9H13NO2, CAS is 2199-44-2, about Selective β-chlorination of 1-benzoyl-2-ethoxycarbonyl-3,5-dimethylpyrrole with iodobenzene dichloride. Preparation of ethyl 4-chloro-3,5-dimethylpyrrole-2-carboxylate. Author is Angelini, Giancarlo; Sleiter, Giancarlo.

Chlorination of I (R = H, R1 = Bz) with PhI+ClCl- in CHCl3 at -15° in the dark, followed by debenzoylation of the product gave I (R = Cl, R1 = H). Reaction of I ( R = R1 = H) with Cl, SO2Cl2, or PhI+ClCl- in CHCl3 or ether at low temperature resulted in simultaneous chlorination of both the β-position and the α-methyl group.

There are many compounds similar to this compound(2199-44-2)Safety of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Chloro-7-nitro-1H-benzo[d]imidazole( cas:15965-55-6 ) is researched.Name: 2-Chloro-7-nitro-1H-benzo[d]imidazole.Chernova, E. Yu.; Mokrushina, G. A.; Chupakhin, O. N.; Kotovskaya, S. K.; Il’enko, V. I.; Andreeva, O. T.; Boreko, E. I.; Vladyko, G. V.; Korobchenko, L. V. published the article 《Synthesis and biological activity of 5,6-dinitro derivatives of benzimidazole》 about this compound( cas:15965-55-6 ) in Khimiko-Farmatsevticheskii Zhurnal. Keywords: virucide dinitrobenzimidazole; benzimidazole dinitro virucide bactericide; bactericide dinitrobenzimidazole. Let’s learn more about this compound (cas:15965-55-6).

The title compounds I [R = H·HCl, Me; R1 = NH2NH, amino, azolyl (II)] were prepared from chlorobenzimidazoles I [R1 = Cl (III)]. III in turn, were prepared by the nitration of 2-chlorobenzimidazole. The antiviral and antimicrobial activity of II were examined

There are many compounds similar to this compound(15965-55-6)Name: 2-Chloro-7-nitro-1H-benzo[d]imidazole. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Application In Synthesis of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, is researched, Molecular C9H13NO2, CAS is 2199-44-2, about Carbon-13 nuclear magnetic resonance spectra of substituted pyrroles. Author is Abraham, Raymond J.; Lapper, Roy D.; Smith, Kevin M.; Unsworth, John F..

The 13C NMR spectra of 55 pyrroles were determined and assigned. The pyrrole ring carbon chem. shifts were predicted, to ∼0.5 ppm, on the basis of additive substituent effects and contributions from steric and conjugative effects. The substituent chem. shift parameters were analogous to those for thiophenes. C-2 substituents affected mainly C-3 and C-5, and C-3 substituents mainly C-2.

Compound(2199-44-2)Application In Synthesis of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate), if you are interested, you can check out my other related articles.

Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Asaula, Vitalii M.; Buryanov, Volodymyr V.; Solod, Bohdan Y.; Tryus, Daryna M.; Pariiska, Olena O.; Kotenko, Igor E.; Volovenko, Yulian M.; Volochnyuk, Dmitriy M.; Ryabukhin, Sergey V.; Kolotilov, Sergey V. researched the compound: 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid( cas:114527-53-6 ).Product Details of 114527-53-6.They published the article 《Catalytic Hydrogenation of Substituted Quinolines on Co-Graphene Composites》 about this compound( cas:114527-53-6 ) in European Journal of Organic Chemistry. Keywords: quinoline preparation catalytic hydrogenation cobalt graphene composite. We’ll tell you more about this compound (cas:114527-53-6).

A set of 20 composites was prepared by pyrolysis of Co2+ complexes with 1,10-phenanthroline, melamine and 1,2-diaminobenzene. These composites were tested as the catalysts for the hydrogenation of quinolines. As shown by powder X-ray diffraction and TEM, the composites contained Co particles of several dozen nm sizes. The composition (elements content), Raman spectra X-ray photoelectron spectra parameters of the composites were analyzed. It was found that there was no distinct factor that controlled the yield of 1,2,3,4-tetrahydroquinolines in the investigated process. The yields of the resp. products were in the range 90-100%. The three most active composites were selected for scale-up and hydrogenation of a series of substituted quinolines. Up to 97% yield of 1,2,3,4-tetrahydroquinoline was obtained on a 50 g scale. Five representative substituted quinolines were synthesized on a 10-20 g scale using the Co-containing composites as the catalysts.

Compound(114527-53-6)Product Details of 114527-53-6 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1,2,3,4-Tetrahydroquinoline-3-carboxylic acid), if you are interested, you can check out my other related articles.

Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com