Synthesis of Chiral Tryptamines via a Regioselective Indole Alkylation was written by Wolfard, Jens;Xu, Jie;Zhang, Haiming;Chung, Cheol K.. And the article was included in Organic Letters in 2018.Category: thiazolidine This article mentions the following:
A practical synthesis of chiral tryptamines from simple, unprotected indoles has been developed. Indole nucleophiles prepared with MeMgCl in the presence of CuCl reacted with chiral cyclic sulfamidates almost exclusively at the C3-position of indole to form a variety of α- and/or β-substituted chiral tryptamines in good yield with excellent regioselectivity. The utility of this simple alkylation process has been demonstrated with the practical synthesis of two biol. active targets, cipargamin and TIK-301, which were completed in three steps starting from the corresponding indole starting materials. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl 4-phenyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide (cas: 479687-23-5Category: thiazolidine).
(S)-tert-Butyl 4-phenyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide (cas: 479687-23-5) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Category: thiazolidine
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com