Tag: 237.2734

Moss, Thomas A. et al. published their research in Tetrahedron Letters in 2017 | CAS: 454248-53-4

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.COA of Formula: C8H15NO5S

A Larock indolization approach to substituted tryptamines was written by Moss, Thomas A.;Lister, Andrew S.;Wang, Jimmy. And the article was included in Tetrahedron Letters in 2017.COA of Formula: C8H15NO5S This article mentions the following:

Substituted tryptamines, an important class of heterocycle in both natural products and medicinal chem., are readily accessible through a Larock indolization approach. The acetylene precursors are in turn routinely accessed as single enantiomers from ring opening of chiral cyclic sulfamidate precursors. Using this two-step protocol, a range of unnatural substituted tryptamines have been synthesized in good yields. In the experiment, the researchers used many compounds, for example, (R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4COA of Formula: C8H15NO5S).

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.COA of Formula: C8H15NO5S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Bailey, Andrew et al. published their research in Tetrahedron Letters in 2018 | CAS: 454248-53-4

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Application of 454248-53-4

Synthesis of trans 8-substituted-6-phenyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolines using a Pictet-Spengler approach was written by Bailey, Andrew;Lister, Andrew;Moss, Thomas;Scott, James S.;Wu, Ye;Lamont, Scott G.. And the article was included in Tetrahedron Letters in 2018.Application of 454248-53-4 This article mentions the following:

Two complementary approaches for the synthesis of trans 8-substituted-6-phenyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolines I [R = iBu, CH2CHF2, CH2CF3, (1-fluorocyclopropyl)methyl, CH2C(Me)2F; Ar = 4-BrC6H4, 5-Br-2-pyridyl, 4-Br-3-F-C6H3, 4_Br-2,6-di-FC6H2, 4-Br-2-MeOC6H3] was reported. The first method, directly from α-Me substituted indazole ethanamines, was successful but had limited substrate scope. The second method utilized a modified Pictet-Spengler cyclization reaction on an aniline substrate followed by late stage construction of the indazole ring and was more versatile in terms of substrate scope. In the experiment, the researchers used many compounds, for example, (R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4Application of 454248-53-4).

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Application of 454248-53-4

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Moss, Thomas A. et al. published their research in Tetrahedron Letters in 2017 | CAS: 454248-53-4

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.COA of Formula: C8H15NO5S

A Larock indolization approach to substituted tryptamines was written by Moss, Thomas A.;Lister, Andrew S.;Wang, Jimmy. And the article was included in Tetrahedron Letters in 2017.COA of Formula: C8H15NO5S This article mentions the following:

Substituted tryptamines, an important class of heterocycle in both natural products and medicinal chem., are readily accessible through a Larock indolization approach. The acetylene precursors are in turn routinely accessed as single enantiomers from ring opening of chiral cyclic sulfamidate precursors. Using this two-step protocol, a range of unnatural substituted tryptamines have been synthesized in good yields. In the experiment, the researchers used many compounds, for example, (R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4COA of Formula: C8H15NO5S).

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.COA of Formula: C8H15NO5S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Moss, Thomas A. et al. published their research in Synlett in 2015 | CAS: 454248-53-4

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.SDS of cas: 454248-53-4

Expedient Synthesis of Highly Functionalised Cyclic Imines was written by Moss, Thomas A.. And the article was included in Synlett in 2015.SDS of cas: 454248-53-4 This article mentions the following:

Aryl- and heteroaryl fused cyclic imines were obtained from the starting acetal via a directed metalation-alkylation-condensation sequence using cyclic sulfamidates as the electrophile. A variety of aromatics and heteroaromatics are applicable to this methodol., which produces highly versatile cyclic imine building blocks for drug discovery and total synthesis programs. In the experiment, the researchers used many compounds, for example, (R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4SDS of cas: 454248-53-4).

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.SDS of cas: 454248-53-4

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Barrows, Robert D. et al. published their research in Journal of Medicinal Chemistry in 2022 | CAS: 454248-53-4

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.HPLC of Formula: 454248-53-4

Potent Uncompetitive Inhibitors of Nicotinamide Methyltransferase (NNMT) as In Vivo Chemical Probes was written by Barrows, Robert D.;Jeffries, Daniel E.;Vishe, Mahesh;Tukachinsky, Hanna;Zheng, Shao-Liang;Li, Fanfan;Ma, Zhenjie;Li, Xiaolei;Jin, Shujuan;Song, Haobin;Zhang, Ruonan;Zhang, Shaofeng;Ni, Jing;Luan, Haofei;Wen, Lei;Rongshan, Yan;Ying, Chen;Shair, Matthew D.. And the article was included in Journal of Medicinal Chemistry in 2022.HPLC of Formula: 454248-53-4 This article mentions the following:

NNMT uses SAM as a cofactor to catalyze the methylation of nicotinamide, producing 1-methylnicotinamide. Recent studies have shown that NNMT upregulation in cancer-associated fibroblasts (CAFs) is required to maintain the CAF phenotype in high-grade serous carcinoma. These observations suggest that NNMT should be evaluated as a therapeutic target, especially in cancer. Although several small-mol. inhibitors of NNMT have been identified, there remains a need for highly potent and selective inhibitors with excellent in vivo activity and ADME properties that can be used as reliable chem. probes. We have identified azaindoline carboxamide as a selective and potent NNMT inhibitor with favorable PK/PD and safety profiles as well as excellent oral bioavailability and pharmaceutical properties. Our mechanistic studies indicate that 38 binds uncompetitively with SAM but competitively with nicotinamide consistent with its binding in the nicotinamide binding site and likely forming a pos. interaction with SAM. In the experiment, the researchers used many compounds, for example, (R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4HPLC of Formula: 454248-53-4).

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.HPLC of Formula: 454248-53-4

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Scott, James S. et al. published their research in Journal of Medicinal Chemistry in 2019 | CAS: 454248-53-4

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. COA of Formula: C8H15NO5S

Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists was written by Scott, James S.;Bailey, Andrew;Buttar, David;Carbajo, Rodrigo J.;Curwen, Jon;Davey, Paul R. J.;Davies, Robert D. M.;Degorce, Sebastien L.;Donald, Craig;Gangl, Eric;Greenwood, Ryan;Groombridge, Sam D.;Johnson, Tony;Lamont, Scott;Lawson, Mandy;Lister, Andrew;Morrow, Christopher J.;Moss, Thomas A.;Pink, Jennifer H.;Polanski, Radoslaw. And the article was included in Journal of Medicinal Chemistry in 2019.COA of Formula: C8H15NO5S This article mentions the following:

Tricyclic tetrahydropyridoindazoles such as I were prepared as estrogen receptor degrader antagonists for potential use in the treatment of ERα-dependent breast cancer; the indazole moiety was prepared as a replacement for a phenol moiety in a tetrahydroisoquinolinol which generated reactive metabolites in a glutathione trapping assay. The structure of a nonracemic tetrahydropyridoindazole bound to an ERα ligand binding domain fragment was determined by X-ray crystallog. I demonstrated the desired estrogen receptor α degrader-antagonist profile and demonstrated activity in a xenograft model of breast cancer. In the experiment, the researchers used many compounds, for example, (R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4COA of Formula: C8H15NO5S).

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. COA of Formula: C8H15NO5S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com