Tag: 161.2882

Bowen, James I. et al. published their research in Organic & Biomolecular Chemistry in 2021 | CAS: 76186-04-4

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Application of 76186-04-4

Ambruticins: Tetrahydropyran ring formation and total synthesis was written by Bowen, James I.;Wang, Luoyi;Crump, Matthew P.;Willis, Christine L.. And the article was included in Organic & Biomolecular Chemistry in 2021.Application of 76186-04-4 This article mentions the following:

The ambruticins are a family of polyketide natural products which exhibit potent antifungal activity. Gene knockout experiments are in accord with the proposal that the tetrahydropyran ring of the ambruticins is formed via the AmbJ catalyzed epoxidation of the unsaturated 3,5-dihydroxy acid, ambruticin J, followed by regioselective cyclization to ambruticin F. Herein, a convergent approach to the total synthesis of ambruticin J (I) is described as well as model studies involving epoxidation and cyclizations of unsaturated hydroxy esters to give tetrahydropyrans and tetrahydrofurans. The total synthesis involves preparation of three key fragments which were united via a Suzuki-Miyaura cross-coupling and Julia-Kocienski olefination to generate the required carbon framework. Global deprotection to a triol and selective oxidation of the primary alc. gave, after hydrolysis of the lactone, ambruticin J. In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4Application of 76186-04-4).

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Application of 76186-04-4

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Pereira, Elaine et al. published their research in Quimica Nova in 2008 | CAS: 76186-04-4

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Application In Synthesis of (S)-4-Isopropylthiazolidine-2-thione

Stereoselective syntheses of (+)-isoretronecanol and (+)-5-epi-tashiromine via addition of chiral titanium(IV) enolates to cyclic N-acyliminium ions was written by Pereira, Elaine;de Fatima Alves, Conceicao;Bockelmann, Maria Alice;Pilli, Ronaldo A.. And the article was included in Quimica Nova in 2008.Application In Synthesis of (S)-4-Isopropylthiazolidine-2-thione This article mentions the following:

The stereoselective addition of the titanium (IV) enolates derived from (S)-4-isopropyl-N-4-chlorobutyryl-1,3-thiazolidine-2-thione and from (S)-4-isopropyl-N-4-chloropentanoyl-1,3-thiazolidine-2-thione to N-Boc-2-methoxypyrrolidine afforded the addition products (+)-I [R = (CH2)2Cl, (CH2)3Cl, resp.] in 84% yield in both cases, as 8.6:1 and 10:1 diastereoisomeric mixtures, resp. A three-step sequence allowed to convert these adducts to (+)-isoretronecanol and (+)-5-epi-tashiromine II [X = CH2, (CH2)2, resp.] in 43% and 49% overall yield, resp. In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4Application In Synthesis of (S)-4-Isopropylthiazolidine-2-thione).

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Application In Synthesis of (S)-4-Isopropylthiazolidine-2-thione

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Deng, Xiao-Bing et al. published their research in Phosphorus, Sulfur and Silicon and the Related Elements in 2011 | CAS: 76186-04-4

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine is an important scaffold and has a wide range of promising biological activities. Thiazolidine derivatives have reported anti-inflammatory and anti-nociceptive activity. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Computed Properties of C6H11NS2

A Convenient Synthesis of Thiazolidin-2-ones from Thiazolidine-2-thiones: Antibiotic Activity and Revisiting the Mechanism was written by Deng, Xiao-Bing;Chen, Ning;Wang, Zhi-Xin;Li, Xin-Yao;Hu, Hong-Yan;Xu, Jia-Xi. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2011.Computed Properties of C6H11NS2 This article mentions the following:

Various substituted thiazolidin-2-ones were synthesized from the corresponding thiazolidine-2-thiones with bromoethanol in ethanol with sodium ethoxide as a base. The optimal reaction conditions and mechanism were reinvestigated in detail. The bioassay indicated that (S)-4-iso-butylthiazolidin-2-one and (S)-4-benzylthiazolidin-2-one show certain inhibitive activities against Candida albicans and Escherichia coli. In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4Computed Properties of C6H11NS2).

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine is an important scaffold and has a wide range of promising biological activities. Thiazolidine derivatives have reported anti-inflammatory and anti-nociceptive activity. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Computed Properties of C6H11NS2

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Han, Zhen et al. published their research in Nano Research in 2020 | CAS: 76186-04-4

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.COA of Formula: C6H11NS2

Intercluster aurophilicity-driven aggregation lighting circularly polarized luminescence of chiral gold clusters was written by Han, Zhen;Zhao, Xueli;Peng, Peng;Li, Si;Zhang, Chong;Cao, Man;Li, Kai;Wang, Zhao-Yang;Zang, Shuang-Quan. And the article was included in Nano Research in 2020.COA of Formula: C6H11NS2 This article mentions the following:

Herein, we prepared two novel pairs of enantiomeric gold cluster complexes, AU4PL4/Au4PD4 and (Au4L4)n/(Au4D4)n with at. precision. In Au4PL4/Au4PD4, the discrete chiral Au4-based aggregation-induced emission (AIE) luminogens are separated by bulky substitutes. The corresponding aggregates are cyan-emitting with a photoluminescence quantum yield (PLQY) of 14.4%. Upon decreasing the size of the substituents, these chiral Au4 clusters are strung together by inter-cluster Au-Au interactions, which cause a low-energy green emission from the aggregated (Au4L4)n/(Au4D4)n with a much higher PLQY of 41.4% and more intense circularly polarised photoluminescence (CPL) with a dissymmetry factor |gPL| of 7.0 x 10-3. Using (Au4L4)n/(Au4D4)n, circularly polarised organic light-emitting diodes (CP-OLEDs) were for the first time fabricated. These findings signify that inter-cluster metallophilic interactions are a new and important type of driving force for AIE and crystallization-induced emission (CIE), suggesting great potential of CPL-active metal clusters in CP-OLEDs. In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4COA of Formula: C6H11NS2).

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.COA of Formula: C6H11NS2

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Arbelo Roman, Cristina et al. published their research in European Journal of Organic Chemistry in 2011 | CAS: 76186-04-4

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Recommanded Product: 76186-04-4

Diastereoselective Synthesis of (Aryloxy)phosphoramidate Prodrugs was written by Arbelo Roman, Cristina;Wasserthal, Philip;Balzarini, Jan;Meier, Chris. And the article was included in European Journal of Organic Chemistry in 2011.Recommanded Product: 76186-04-4 This article mentions the following:

The first diastereoselective synthesis of aryloxyphosphoramidate prodrugs of 3′-deoxy-2′,3′-didehydrothymidine monophosphate (d4TMP) was recently reported. The synthetic approach utilized the chiral auxiliary (S)-4-isopropylthiazolidine-2-thione. For this strategy, a stereochem. pure phosphorodiamidate intermediate was needed. The diastereoselective formation of this key compound was investigated by using different phenols and L-alanine Me or benzyl ester. Generally, the reaction with 3- or 4-substituted phenols led to significantly better diastereoselectivities compared to their 2-substituted counterparts. Moreover, variation of the ester group in the amino acid residue resulted in no significant differences with regard to the obtained diastereoselectivity. From the reported results, a model for the transition state was elaborated. Finally, eight new (SP)-arylphosphoramidates were synthesized with very high diastereoselectivities (up to ≥ 95 % de) and tested for their anti-HIV potency, showing a tendency for higher antiviral activity from the (SP) diastereomers. In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4Recommanded Product: 76186-04-4).

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Recommanded Product: 76186-04-4

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Fernandez-Valparis, Javier et al. published their research in Organic Letters in 2017 | CAS: 76186-04-4

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Recommanded Product: 76186-04-4

Stereoselective and Catalytic Synthesis of anti-β-Alkoxy-α-azido Carboxylic Derivatives was written by Fernandez-Valparis, Javier;Romea, Pedro;Urpi, Felix;Font-Bardia, Merce. And the article was included in Organic Letters in 2017.Recommanded Product: 76186-04-4 This article mentions the following:

Nonracemic azidoacetyl thiazolidinethione I was prepared; in the presence of NiCl2(PMe3)2, I underwent diastereoselective condensation reactions with aryl aldehyde acetals RCH(OR1)2 (R = 4-MeOC6H4, 3-MeOC6H4, 2-MeOC6H4, 1,3-benzodioxol-5-yl, 4-Me2NC6H4, 4-MeC6H4, Ph, 4-ClC6H4; R1 = Me, H2C:CHCH2, PhCH2) and alkynyl dicobalt hexacarbonyl complexes mediated by Et3SiOTf and 2,6-lutidine in CH2Cl2 to yield nonracemic β-alkoxy-β-aryl-α-azidopropanoyl thiazolidinethiones such as II (R = 4-MeOC6H4, 3-MeOC6H4, 2-MeOC6H4, 1,3-benzodioxol-5-yl, 4-Me2NC6H4, 4-MeC6H4, Ph, 4-ClC6H4; R1 = Me, H2C:CHCH2, PhCH2) and dicobalt hexacarbonyl β-alkoxy-α-azidobutynoyl thiazolidinethiones in 15-85% yields (three of eighteen examples < 50% yields) and in 60:40->97:3 dr (three of eighteen examples < 80:20 dr). In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4Recommanded Product: 76186-04-4).

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Recommanded Product: 76186-04-4

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Nagao, Yoshimitsu et al. published their research in Journal of Organic Chemistry in 1989 | CAS: 76186-04-4

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidine is prepared as it was in its first reported synthesis, by the condensation of cysteamine and formaldehyde. Other thiazolidines may be synthesized by similar condensations. A notable derivative is 4-carboxythiazolidine, derived from formaldehyde and cysteine.Quality Control of (S)-4-Isopropylthiazolidine-2-thione

New general asymmetric synthesis of versatile γ-alkylated butenolides and its application to expeditious synthesis of the chiral Geissman-Waiss lactones useful for (+)-retronecine synthesis was written by Nagao, Yoshimitsu;Dai, Wei Min;Ochiai, Masahito;Shiro, Motoo. And the article was included in Journal of Organic Chemistry in 1989.Quality Control of (S)-4-Isopropylthiazolidine-2-thione This article mentions the following:

A new strategy for general asym. synthesis of chiral butenolides, e.g. I, is established by utilizing excellent diastereocontrolled alkylation with chiral tin(II) enolate of II at the γ-position of hydroxy butenolides. An efficient utility of the chiral butenolides is exemplified with the expeditious synthesis of the optically pure Geissman-Waiss lactone derivatives III (R = CO2Et, CH2O2CCMe3). In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4Quality Control of (S)-4-Isopropylthiazolidine-2-thione).

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidine is prepared as it was in its first reported synthesis, by the condensation of cysteamine and formaldehyde. Other thiazolidines may be synthesized by similar condensations. A notable derivative is 4-carboxythiazolidine, derived from formaldehyde and cysteine.Quality Control of (S)-4-Isopropylthiazolidine-2-thione

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Jeong, Tae Myoung et al. published their research in Taehan Hwahakhoe Chi in 1988 | CAS: 76186-04-4

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Open-chain compounds are obtained when thiazolidines are treated with tris(trimethylsilyl)silane in a reaction in which the thiazolidine derivatives act as a source of α-aminoalkyl radicals.COA of Formula: C6H11NS2

A highly stereoselective reaction in aminolysis of 3-acyl-4(S)-isopropyl-1,3-thiazolidinethione with racemic amines was written by Jeong, Tae Myoung;Park, Ki Hun. And the article was included in Taehan Hwahakhoe Chi in 1988.COA of Formula: C6H11NS2 This article mentions the following:

Chiral recognition was observed in aminolysis of title thiazolidinethiones I [R = Me(CH2)10, 1-C10H7] by racemic amino acid esters to give an optically active amide (S-excess) and amino acid esters (R-excess). The rate of this aminolysis is affected by steric surrounding; completion of reaction can be easily judged by the disappearance of the original yellow color of I. I were synthesized from (S)-4-isopropyl-1,3-thiazolidine-2-thione and carboxylic acids. In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4COA of Formula: C6H11NS2).

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Open-chain compounds are obtained when thiazolidines are treated with tris(trimethylsilyl)silane in a reaction in which the thiazolidine derivatives act as a source of α-aminoalkyl radicals.COA of Formula: C6H11NS2

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Jeong, Tae Myoung et al. published their research in Taehan Hwahakhoe Chi in 1988 | CAS: 76186-04-4

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Open-chain compounds are obtained when thiazolidines are treated with tris(trimethylsilyl)silane in a reaction in which the thiazolidine derivatives act as a source of α-aminoalkyl radicals.COA of Formula: C6H11NS2

A highly stereoselective reaction in aminolysis of 3-acyl-4(S)-isopropyl-1,3-thiazolidinethione with racemic amines was written by Jeong, Tae Myoung;Park, Ki Hun. And the article was included in Taehan Hwahakhoe Chi in 1988.COA of Formula: C6H11NS2 This article mentions the following:

Chiral recognition was observed in aminolysis of title thiazolidinethiones I [R = Me(CH2)10, 1-C10H7] by racemic amino acid esters to give an optically active amide (S-excess) and amino acid esters (R-excess). The rate of this aminolysis is affected by steric surrounding; completion of reaction can be easily judged by the disappearance of the original yellow color of I. I were synthesized from (S)-4-isopropyl-1,3-thiazolidine-2-thione and carboxylic acids. In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4COA of Formula: C6H11NS2).

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Open-chain compounds are obtained when thiazolidines are treated with tris(trimethylsilyl)silane in a reaction in which the thiazolidine derivatives act as a source of α-aminoalkyl radicals.COA of Formula: C6H11NS2

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Nagao, Yoshimitsu et al. published their research in Journal of Organic Chemistry in 1989 | CAS: 76186-04-4

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidine is prepared as it was in its first reported synthesis, by the condensation of cysteamine and formaldehyde. Other thiazolidines may be synthesized by similar condensations. A notable derivative is 4-carboxythiazolidine, derived from formaldehyde and cysteine.Quality Control of (S)-4-Isopropylthiazolidine-2-thione

New general asymmetric synthesis of versatile γ-alkylated butenolides and its application to expeditious synthesis of the chiral Geissman-Waiss lactones useful for (+)-retronecine synthesis was written by Nagao, Yoshimitsu;Dai, Wei Min;Ochiai, Masahito;Shiro, Motoo. And the article was included in Journal of Organic Chemistry in 1989.Quality Control of (S)-4-Isopropylthiazolidine-2-thione This article mentions the following:

A new strategy for general asym. synthesis of chiral butenolides, e.g. I, is established by utilizing excellent diastereocontrolled alkylation with chiral tin(II) enolate of II at the γ-position of hydroxy butenolides. An efficient utility of the chiral butenolides is exemplified with the expeditious synthesis of the optically pure Geissman-Waiss lactone derivatives III (R = CO2Et, CH2O2CCMe3). In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4Quality Control of (S)-4-Isopropylthiazolidine-2-thione).

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidine is prepared as it was in its first reported synthesis, by the condensation of cysteamine and formaldehyde. Other thiazolidines may be synthesized by similar condensations. A notable derivative is 4-carboxythiazolidine, derived from formaldehyde and cysteine.Quality Control of (S)-4-Isopropylthiazolidine-2-thione

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com