Some tips on 14446-47-0

14446-47-0, As the paragraph descriping shows that 14446-47-0 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14446-47-0,Thiazolidine hydrochloride,as a common compound, the synthetic route is as follows.

N-t-Butyloxycarbonylglutamine (2.0 g, 8.12 mmol) was dissolved in THF (5 mL) and cooled TO-15C. CAIBE (ISOBUTYLCHLOROFORMATE) (1.06 mL, 8.12 mmol) and 4- METHYLMORPHOLINE (0.895 mL, 8.12 mmol) were added and the solution stirred for 15 min, The formation of the mixed anhydride was checked by TLC (eluent: CHCL3/MEOH : 9/1). After warming to-10C another equivalent of 4-methylmorpholine (0.895 mL, 8.12 mmol) and THIAZOLIDINEHYDROCHLORIDE (1.02 g, 8. 12 mmol) was added. The mixture was brought to room temperature and stirred overnight. The sediment FORMED was filtered off and the solvent was evaporated. The resulting oil was taken up in chloroform (20 ml) and washed with a saturated solution of sodium hydrogensulfate followed by a saturated solution of sodium bicarbonate, water and brine. The organic layer was separated, dried and evaporated. The resulting product was checked for purity by TLC (eluent: CHC13/MEOH : 9/1). Yield: 1.64 g. A portion of this product (640 mg) was dissolved in 3.1 mL ice cold HCl in dioxane (12.98 M, 20 equivalents) and left on ice. The progress of the reaction was monitored by TLC (eluent: CHCL3/MEOH : 9/1). After completion of the reaction the solvent was removed and the resulting residue was taken up in methanol and evaporated again. The resulting oil was dried over phosphorous-V-oxide and triturated twice with diethylether to give the title compound (0.265 g). The purity was checked by HPLC. The identity of the reaction product was checked by NMR analysis.

14446-47-0, As the paragraph descriping shows that 14446-47-0 is playing an increasingly important role.

Reference£º
Patent; PROSIDION LTD.; WO2005/20983; (2005); A2;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

Analyzing the synthesis route of 14446-47-0

14446-47-0 Thiazolidine hydrochloride 12444283, athiazolidine compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14446-47-0,Thiazolidine hydrochloride,as a common compound, the synthetic route is as follows.

Example 58 1-(4-bromophenyl)-3-(3-thiazolidinyl)propan-1-one 12.56 g (0.1 mol) of thiazolidine hydrochloride, 19.9 (0.1 mol) of 4-bromoacetophenone, 12 ml of 36% formaldehyde solution (0.144 mol), 30 ml of ethanol and 5 drops of concentrated hydrochloric acid are mixed and then heated. After a short reflux period, a homogenous solution is formed. After 7 hours boiling, the solution is evaporated, the oily residue is poured into 1000 ml of acetone under stirring and the precipitated starting material is filtered off. After evaporating the filtrate, the residue is recrystallized from ethanol or methanol to give the hydrochloride salt of the title compound, m.p.: 170C.

14446-47-0 Thiazolidine hydrochloride 12444283, athiazolidine compound, is more and more widely used in various.

Reference£º
Patent; RICHTER GEDEON VEGYESZETI GYAR R.T.; EP411775; (1991); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com