Tag: 1438-16-0

The thiazolidine compound, cas is 1438-16-0 name is 3-Aminorhodanine, mainly used in chemical industry, its synthesis route is as follows.

General procedure: A mixture of aminorhodanine (1 mmol), isatin (1 mmol) and 5 muL of acetic acid in 2mL of distilled ethanol was placed in a cylindrical quartz reactor (Phi = 4 cm). The reactor was introducedinto a monomode microwave (Anton Paar) apparatus, for 5 min at100 C and 50 Watts. The crude reaction mixture was allowed tocool down at room temperature and ethanol (10 mL) or mixture of H2O/EtOH (10 mL) was directly added in the cylindrical quartzreactor. The resulting precipitated product was filtered off and waspurified by recrystallization from ethanol if necessary.

1438-16-0, As the rapid development of chemical substances, we look forward to future research findings about 1438-16-0

Reference£º
Article; Khaldoun, Khadidja; Safer, Abdelmounaim; Boukabcha, Nourdine; Dege, Necmi; Ruchaud, Sandrine; Souab, Mohamed; Bach, Stephane; Chouaih, Abdelkader; Saidi-Besbes, Salima; Journal of Molecular Structure; vol. 1192; (2019); p. 82 – 90;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

The thiazolidine compound, cas is 1438-16-0 name is 3-Aminorhodanine, mainly used in chemical industry, its synthesis route is as follows.

EXAMPLE 37 3-[(1,3-Benzodithiol-2-ylidene)amino]-2-thioxo-4-thiazolidinone A solution of N-(1,3-benzodithiol-2-ylidene)-N-methylbenzaminium iodide (3.85g), N-aminorhodanine (1.48g) and anhydrous sodium carbonate (530 mg) in 100 ml of anhydrous dimethylformamide is heated at 120 C under a nitrogen atmosphere for 2 hours. The reaction mixture is then poured into 500 ml of ice/water and left stirring at 4 C for 2 hours. The resultant precipitate is collected by filtration and washed several times with cold water. The solid is air dried to yield 2.0g of crude product. This product is recrystallized from dimethylformamide to yield 1.9g of the title compound, melting point 295-300 C. Anal. Calc’d. for C10 H6 N2 OS4: C, 40.25; H, 2.03; N, 9.39; S, 42.98. Found: C, 40.27; H, 2.20; N, 9.30; S, 43.05.

1438-16-0, As the rapid development of chemical substances, we look forward to future research findings about 1438-16-0

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Patent; E. R. Squibb & Sons, Inc.; US4104467; (1978); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

1438-16-0, 3-Aminorhodanine is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1438-16-0

General procedure: To a reaction vessel was added compound19(70 mg, 0.16 mmol), thiazolidine-2,5-dione (28 mg, 0.25 mmol), piperidine (2 muL, 0.02 mmol) and acetic acid (1 muL, 0.02 mmol) in the presence of toluene. The reaction mixture was refluxed overnight and the reaction solvent was removed by evaporation. The residual was dissolved in EtOAc and washed with H2O (2 x 10 mL) and brine. The organic layer was collected, dried over anhydrous Na2SO4, filtered, concentrated and purifiedby silica gel column chromatography using 20% EtOAc in hexanes to afford compound20(57 mg, 66%).

The synthetic route of 1438-16-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kim, Hyojin; Cho, Suk Joon; Yoo, Minjin; Kang, Seung Kyu; Kim, Kwang Rok; Lee, Hwan Hee; Song, Jin Sook; Rhee, Sang Dal; Jung, Won Hoon; Ahn, Jin Hee; Jung, Jae-Kyung; Jung, Kwan-Young; Bioorganic and Medicinal Chemistry Letters; vol. 27; 23; (2017); p. 5213 – 5220;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

3-Aminorhodanine, cas is 1438-16-0, it is a common heterocyclic compound, the thiazolidine compound, its synthesis route is as follows.

General procedure: A mixture of isothiocyanatobenzenesulfonamide 2 [32](0.01mol) and heterocyclic amine (0.01mol) in dioxane (30mL) containing triethylamine (0.1mL) was refluxed for 1h. The solvent was evaporated under reduced pressure and the solid obtained was filtered, washed with petroleum ether (bp 40-60C) and crystallized from ethanol to afford the thiourea derivatives.

1438-16-0, With the rapid development of chemical substances, we look forward to future research findings about 1438-16-0

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Article; Ghorab, Mostafa M.; Alsaid, Mansour S.; El-Gaby, Mohamed S.A.; Safwat, Nesreen A.; Elaasser, Mahmoud M.; Soliman, Aiten M.; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 299 – 310;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

3-Aminorhodanine, cas is 1438-16-0, it is a common heterocyclic compound, the thiazolidine compound, its synthesis route is as follows.

General procedure: A mixture of aminorhodanine (1 mmol), isatin (1 mmol) and 5 muL of acetic acid in 2mL of distilled ethanol was placed in a cylindrical quartz reactor (Phi = 4 cm). The reactor was introducedinto a monomode microwave (Anton Paar) apparatus, for 5 min at100 C and 50 Watts. The crude reaction mixture was allowed tocool down at room temperature and ethanol (10 mL) or mixture of H2O/EtOH (10 mL) was directly added in the cylindrical quartzreactor. The resulting precipitated product was filtered off and waspurified by recrystallization from ethanol if necessary.

1438-16-0, With the rapid development of chemical substances, we look forward to future research findings about 1438-16-0

Reference£º
Article; Khaldoun, Khadidja; Safer, Abdelmounaim; Boukabcha, Nourdine; Dege, Necmi; Ruchaud, Sandrine; Souab, Mohamed; Bach, Stephane; Chouaih, Abdelkader; Saidi-Besbes, Salima; Journal of Molecular Structure; vol. 1192; (2019); p. 82 – 90;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1438-16-0,3-Aminorhodanine,as a common compound, the synthetic route is as follows.,1438-16-0

General procedure: General procedure for synthesis of N-substituted-rhodanine derivatives RhAs: To a solution of aldehydes (3a-3h, 1.0 equiv.) in ethanol (10 mL) was added slowly to the solution of 3-amino-2-thioxothiazolidin-4-one (2, 1.0 equiv.) in EtOH. The reaction mixture was stirred at room temperature without a catalyst for between 4 h and 12 h, and was monitored by TLC. After, the mixture product was recrystallized from EtOH. After recrystallization, N-substituted-rhodanine derivatives (RhAs) were obtained as follows.

The synthetic route of 1438-16-0 has been constantly updated, and we look forward to future research findings.

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Article; Bayindir; Caglayan, Cuneyt; Karaman, Muhammet; Guelcin, ?lhami; Bioorganic Chemistry; vol. 90; (2019);,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

3-Aminorhodanine, cas is 1438-16-0, it is a common heterocyclic compound, the thiazolidine compound, its synthesis route is as follows.,1438-16-0

EXAMPLE 49 3-[(5-Nitro-1,3-benzodithiol-2-ylidene)amino]-2-thioxo-4-thiazolidinone A slurry of 4.24 g of N-methyl-N-(5-nitro-1,3-benzodithiol-2-ylidene)benzaminium iodide, N-aminorhodanine (1.47 g), and sodium carbonate (523 mg) in 100 ml of dimethylformamide is heated at 120-140 C for 2 hours. The reaction solution is chilled in an ice water bath and the resultant precipitate collected by filtration. The precipitate is recrystallized twice from dimethylformamide to yield 1.2 g of the title compound, melting point 315 C. Anal. Calc’d. for C10 H5 N3 O3 S4: C, 34.98; H, 1.47; N, 12.24; S, 37.34. Found: C, 35.20; H, 1.36; N, 12.49; S, 37.62.

With the synthetic route has been constantly updated, we look forward to future research findings about 3-Aminorhodanine,belong thiazolidine compound

Reference£º
Patent; E. R. Squibb & Sons, Inc.; US4104467; (1978); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

As a common heterocyclic compound, it belong thiazolidine compound,3-Aminorhodanine,1438-16-0,Molecular formula: C3H4N2OS2,mainly used in chemical industry, its synthesis route is as follows.,1438-16-0

To a solution of isatin (1, 100.0 mg, 0.68 mmol) in ethanol (10 mL)was added slowly to the solution of 3-amino-rhodanine (2, 100,7 mg,0.68 mmol) using dropwise. The reaction mixture was stirred forovernight at room temperature without catalyst, and was monitored byTLC. After the completion of the reaction, the red product formed wasrecrystallized from ethanol, filtered, and dried in vacuo. After recrystallization,3 (162 mg, 86%), which is E isomer, was obtained asdark yellow solid (m.p. > 300 C). 1H-NMR (400 MHz, DMSO-d6): delta11.34 (s, NH, 1 H), 8.68 (d, J =7.6 Hz, =CH, 1 H), 7.83 (d, J=7.6 Hz, =CH, 1 H), 7.62 (t, J =7.6 Hz, =CH, 1 H), 7.18 (t, J=7.6 Hz, =CH, 1 H), 4.22 (s, CH2, 2 H); 13C-NMR (100 MHz, DMSOd6):delta 193.4, 169.5, 165.0, 146.3, 134.7, 130.1, 129.3, 123.7, 121.9,34.2 (Fig. S3).

With the synthetic route has been constantly updated, we look forward to future research findings about 3-Aminorhodanine,belong thiazolidine compound

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Article; Bayindir, Sinan; Journal of Photochemistry and Photobiology A: Chemistry; vol. 372; (2019); p. 235 – 244;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

3-Aminorhodanine, cas is 1438-16-0, it is a common heterocyclic compound, the thiazolidine compound, its synthesis route is as follows.

The 3-amino-2-thioxothiazolidin-4-one (2, 3-amino-rhodanine,302.2 mg, 2.04 mmol) in ethanol (15 mL) was heated to boiling for10 min, and the solution of indoline-2,3-dione (1, isatin, 300.0 mg,2.04 mmol) in ethanol (15 mL) was added slowly using dropwise. Thereaction mixture was stirred for 5 h at 100 C without catalyst, and wasmonitored by TLC. After the completion of the reaction, the red productformed was recrystallized from ethanol, filtered, and dried in vacuo.After recrystallization, 2-OxI-Rh (407 mg, 72%), which is Z isomer, wasobtained as red solid (m.p. > 300 C). 1H-NMR (400 MHz, DMSO-d6):delta 11.25 (s, NH, 1 H), 8.82 (d, J =7.7 Hz, =CH, 1 H), 7.42 (t, J=7.7 Hz, =CH, 1 H), 7.10 (t, J =7.7 Hz, =CH, 1 H), 6.97 (d, J=7.7 Hz, =CH, 1 H), 5.97 (bs, NH2, 2 H); 13C-NMR (100 MHz, DMSOd6):delta 191.9, 168.0, 163.5, 144.8, 133.2, 128.6, 127.8, 125.5, 122.2,119.9, 110.7 (Fig. S1); IR (KBr, cm-1): 3410 cm-1 (NH2, stretch primary),3146 cm-1 (]CeH, isatin H), 1713 cm-1 (C]O), 1632 cm-1(O]C-NeC]S), 1595 cm-1 (CeC, stretch in ring), 1458, 1335 cm-1(C]S), 1189 cm-1 (CeN, stretch peak), 742 cm-1 (NH2 wag) (Fig. S2);Anal. Calcd. for C11H7N3O2S2: C, 47.64; H, 2.54; N, 15.15; O, 11.54; S,23.12; found: C, 47.57; H, 2.31; N, 15.07

1438-16-0, With the rapid development of chemical substances, we look forward to future research findings about 1438-16-0

Reference£º
Article; Bayindir, Sinan; Journal of Photochemistry and Photobiology A: Chemistry; vol. 372; (2019); p. 235 – 244;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1438-16-0,3-Aminorhodanine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of aminorhodanine (1 mmol), isatin (1 mmol) and 5 muL of acetic acid in 2mL of distilled ethanol was placed in a cylindrical quartz reactor (Phi = 4 cm). The reactor was introducedinto a monomode microwave (Anton Paar) apparatus, for 5 min at100 C and 50 Watts. The crude reaction mixture was allowed tocool down at room temperature and ethanol (10 mL) or mixture of H2O/EtOH (10 mL) was directly added in the cylindrical quartzreactor. The resulting precipitated product was filtered off and waspurified by recrystallization from ethanol if necessary., 1438-16-0

The synthetic route of 1438-16-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Khaldoun, Khadidja; Safer, Abdelmounaim; Boukabcha, Nourdine; Dege, Necmi; Ruchaud, Sandrine; Souab, Mohamed; Bach, Stephane; Chouaih, Abdelkader; Saidi-Besbes, Salima; Journal of Molecular Structure; vol. 1192; (2019); p. 82 – 90;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com