Tag: 133.1689

The effect of 2-substituted thiazolidine-4(R)-carboxylic acids on non-protein sulphydryl levels and sulphurtransferase activities in mouse liver and brain. was written by Włodek, L;Radomski, J;Wróbel, M. And the article was included in Biochemical pharmacology in 1993.SDS of cas: 16310-13-7 This article mentions the following:

2-Substituted thiazolidine-4(R)-carboxylic acids (TD) were found to increase the concentration of non-protein sulphydryls (NPSH) and the activity of rhodanese (thiosulphate sulphurtransferase, EC 2.8.1.1) and 3-mercaptopyruvate sulphurtransferase (EC 2.8.1.2) in mouse liver. These properties suggest TDs are potentially hepatoprotective compounds. However TDs also cause depletion of NPSH in the mouse brain and this may be the reason for their toxic side effects on the central nervous system. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7SDS of cas: 16310-13-7).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.SDS of cas: 16310-13-7

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Quantification of Thiazolidine-4-carboxylic Acid in Toxicant-Exposed Cells by Isotope-Dilution Liquid Chromatography-Mass Spectrometry Reveals an Intrinsic Antagonistic Response to Oxidative Stress-Induced Toxicity was written by Liu, Jingjing;Chan, Wan. And the article was included in Chemical Research in Toxicology in 2015.Application of 444-27-9 This article mentions the following:

Carcinogenic formaldehyde is produced by endogenous protein oxidation and various exogenous sources. With formaldehyde being both ubiquitous in the ambient environment and one of the most common reactive carbonyls produced from endogenous metabolism, quantifying formaldehyde exposure is an essential step in risk assessments. The authors present in this study an approach to assess the risk of exposure to oxidative stress by quantifying thiazolidine-4-carboxylic acid (TA), a cysteine-conjugated metabolite of formaldehyde in toxicant-exposed Escherichia coli. The method entails TA derivatization with Et chloroformate, addition of isotope-labeled TA derivatives as internal standards, solid-phase extraction of the derivatives, and quantification by liquid chromatog.-mass spectrometry (LC-MS). After validating for accuracy and precision, the developed method was used to detect TA in oxidizing agent-exposed E. coli samples. Dose-dependent TA formation was observed in E. coli exposed to hydroxyl radical mediators Fe²⁺-EDTA, H₂O₂, and NaOCl, indicating the potential use of TA as a biomarker of exposure to oxidative stress and disease risk. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Application of 444-27-9).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Application of 444-27-9

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Identification and Quantitation of Key Aroma Compounds Formed in Maillard-type Reactions of Fructose with Cysteamine or Isothiaproline (1,3-Thiazolidine-2-carboxylic Acid) was written by Engel, Wolfgang;Schieberle, Peter. And the article was included in Journal of Agricultural and Food Chemistry in 2002.Category: thiazolidine This article mentions the following:

Fructose was reacted in the presence of either cysteamine (model A) or isothiaproline (model B) in aqueous buffer at 145 °C and pH 7.0. Application of an aroma extract dilution anal. on the bulk of the volatile compounds formed in model A revealed 5-acetyl-3,4-dihydro-2H-1,4-thiazine (19), N-(2-mercaptoethyl)-1,3-thiazolidine, 4-hydroxy-2,5-dimethyl-3(2H)-furanone, and 2-acetyl-2-thiazoline (11) as the key aroma compounds among the 10 odorants detected. A similar set of aroma compounds was formed when isothiaproline was reacted (model B), but the flavor dilution factors were generally lower. Substitution of the buffer by silica gel/water (9 + 1 weight/weight) in both models and application of 150 °C for 10 min also gave the same key odorants from both thio compounds; however, under these conditions isothiaproline was the better precursor of, in particular, 19 and 11. Quant. measurements performed by means of stable isotope dilution assays revealed a significant effect of the pH on odorant formation. For example, in model A, formation of 19 as well as of 11 was suppressed at pH values <5.0. A clear maximum was, however, found for 19 at pH 7.0 (∼1 mol % yield), whereas 11 increased with increasing pH from 7.0 to 9.0. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Category: thiazolidine).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Category: thiazolidine

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4-b]quinoline Hybrid Heterocycles was written by Sumesh, Remani Vasudevan;Muthu, Muthumani;Almansour, Abdulrahman I.;Suresh Kumar, Raju;Arumugam, Natarajan;Athimoolam, S.;Jeya Yasmi Prabha, E. Arockia;Kumar, Raju Ranjith. And the article was included in ACS Combinatorial Science in 2016.HPLC of Formula: 444-27-9 This article mentions the following:

The stereoselective syntheses of a library of novel spiro-tethered pyrazolo[3,4-b]quinoline-pyrrolidine/pyrrolothiazole/indolizine-oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from α-amino acids and 1,2-diketones to dipolarophiles derived from pyrazolo[3,4-b]quinoline derivatives In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9HPLC of Formula: 444-27-9).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.HPLC of Formula: 444-27-9

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties was written by Scott, Gary K.;Mahoney, Sophia;Scott, Madeleine;Loureiro, Ashley;Lopez-Ramirez, Alejandro;Tanner, John J.;Ellerby, Lisa M.;Benz, Christopher C.. And the article was included in Amino Acids in 2021.Application of 16310-13-7 This article mentions the following:

Proline dehydrogenase (PRODH) is a mitochondrial inner membrane flavoprotein critical for cancer cell survival under stress conditions and newly recognized as a potential target for cancer drug development. Reversible (competitive) and irreversible (suicide) inhibitors of PRODH have been shown in vivo to inhibit cancer cell growth with excellent host tolerance. Surprisingly, the PRODH suicide inhibitor N-propargylglycine (N-PPG) also induces rapid decay of PRODH with concordant upregulation of mitochondrial chaperones (HSP-60, GRP-75) and the inner membrane protease YME1L1, signifying activation of the mitochondrial unfolded protein response (UPR^mt) independent of anticancer activity. The present study was undertaken to address two aims: (i) use PRODH overexpressing human cancer cells (ZR-75-1) to confrm the UPR^mt inducing properties of N-PPG relative to another equipotent irreversible PRODH inhibitor, thiazolidine-2-carboxylate (T2C); and (ii) employ biochem. and transcriptomic approaches to determine if orally administered N-PPG can penetrate the blood-brain barrier, essential for its future use as a brain cancer therapeutic, and also potentially protect normal brain tissue by inducing mitohormesis. Oral daily treatments of N-PPG produced a dose-dependent decline in brain mitochondrial PRODH protein without detectable impairment in mouse health; furthermore, mice repeatedly dosed with 50 mg/kg N-PPG showed increased brain expression of the mitohormesis associated protease, YME1L1. Whole brain transcriptome (RNAseq) analyses of these mice revealed signifcant gene set enrichment in N-PPG stimulated neural processes (FDR p<0.05). Given this in vivo evidence of brain bioavailability and neural mitohormesis induction, N-PPG appears to be unique among anticancer agents and should be evaluated for repurposing as a pharmaceutical capable of mitigating the proteotoxic mechanisms driving neurodegenerative disorders. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Application of 16310-13-7).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine is an important scaffold and has a wide range of promising biological activities. Thiazolidine derivatives have reported anti-inflammatory and anti-nociceptive activity. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Application of 16310-13-7

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

6′-(3-Bromophenyl)-7′-nitro-1′,6′,7′,7a′-tetrahydro-3′H-spiro[indeno[1,2-b]quinoxaline-11,5′-pyrrolo[1,2-c]thiazole] was written by Muthuselvi, C.;Muthu, M.;Athimoolam, S.;Ravikumar, B.;Pandiarajan, S.;Krishnakumar, R. V.. And the article was included in IUCrData in 2018.Safety of Thiazolidine-4-carboxylic acid This article mentions the following:

The title compound, C₂₆H₁₉BrN₄O₂S, crystallizes in a monoclinic C-centered lattice with eight mols. in the unit cell. The five-membered thiazole and pyrrolidine rings adopt envelope conformations and the bromophenyl and indenoquinoxaline planes are oriented at a dihedral angle of 61.6 (1)° to each other. The mol. structure features an intramol. C-H···N interaction leading to an S(6) ring motif. C(9) and C(10) chains along the c- and b-axis directions form through C-H···Br and C-H···S contacts, resp. In addition, C-H···O and C-H···N hydrogen bonds form inversion dimers with R²₂(10) and R²₂(14) motifs, resp. One O atom is disordered over two positions (occupancy ratio 0.63:0.37). In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Safety of Thiazolidine-4-carboxylic acid).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Open-chain compounds are obtained when thiazolidines are treated with tris(trimethylsilyl)silane in a reaction in which the thiazolidine derivatives act as a source of α-aminoalkyl radicals.Safety of Thiazolidine-4-carboxylic acid

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Effects of wild zooplankton versus enriched rotifers and Artemia on the biochemical composition of Atlantic cod (Gadus morhua) larvae was written by Rocha, Giseli Swerts;Katan, Tomer;Parrish, Christopher C.;Kurt Gamperl, A.. And the article was included in Aquaculture in 2017.Computed Properties of C4H7NO2S This article mentions the following:

Diet at start feeding can affect fish development, pigmentation and growth, and live feed can provide all the dietary requirements of larvae. Enriched rotifers and Artemia are normally used as live feed in the first stages of com. larval production, however, wild zooplankton or copepods provide better results. The goal of this study was to evaluate whether supplementing enriched rotifers and Artemia (RA) with fish protein hydrolyzate (RA-PH) or a small amount of wild zooplankton (RA-Zoo; 5-10% of total prey items) would improve the nutritional quality of larval cod (Gadus morhua), and how it correlated with larval growth rates. Wild zooplankton had significantly higher proportions of the polyunsaturated fatty acids 22:6ω3 (DHA, 23%) and 20:5ω3 (EPA, 11%). Larvae fed wild zooplankton also had higher proportions of essential omega-3 fatty acids (43% RA-Zoo; ≈ 39-40% RA/RA-PH) and much higher EPA/ARA ratios compared to those only fed with enriched rotifers and Artemia or these prey items plus protein hydrolyzate (≈ 4 RA-Zoo; ≈ 1.3-3 RA/RA-PH). Further, these fatty acid proportions correlated significantly with larval growth rates and improved fish development. Based on these results, we recommend the inclusion of small amounts of wild zooplankton or com. produced copepods with high proportions of DHA and EPA, and low proportions of ARA, in the initial diet of Atlantic cod larvae. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Computed Properties of C4H7NO2S).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine is an important scaffold and has a wide range of promising biological activities. Thiazolidine derivatives have reported anti-inflammatory and anti-nociceptive activity. Open-chain compounds are obtained when thiazolidines are treated with tris(trimethylsilyl)silane in a reaction in which the thiazolidine derivatives act as a source of α-aminoalkyl radicals.Computed Properties of C4H7NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Endogenous alkaloids in man. XXI. Analysis of glyoxylate-derived 1,3-thiazolidines and their precursors after trimethylsilylation by gas chromatography-mass spectrometry was written by Bringmann, Gerhard;Hesselmann, Christiana;Feineis, Doris. And the article was included in Journal of Chromatography A in 1995.Application of 16310-13-7 This article mentions the following:

A gas chromatog. procedure was developed for the simultaneous anal. of glyoxylate-derived 1,3-thiazolidines and their precursors, such as L-cysteine, cysteamine, and D-(-)-penicillamine as well as the toxic glyoxylic acid. The assay involves conversion of these highly polar compounds to volatile trimethylsilyl (TMS) derivatives, chromatog. on a polar fused-silica capillary column, and determination using flame-ionization detection or electron-impact ionization mass spectrometry. On the basis of this anal. device, the resolution of the diastereomeric pairs of 1,3-thiazolidine-2,4-dicarboxylic acids was achieved. Based upon the observation that no epimerization occurs during the silylation procedure, for the first time a reliable method was established for the determination of the diastereomeric ratio of such alkaloid-type heterocycles on a trace scale. Furthermore, studies concerning thiazolidine formation under derivatization conditions in the presence of the precursors glyoxylic acid and D-(-)-penicillamine are described. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Application of 16310-13-7).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Application of 16310-13-7

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Synthesis, Characterization, and Cytotoxicity of New Spirooxindoles Engrafted Furan Structural Motif as a Potential Anticancer Agent was written by Altowyan, Mezna Saleh;Soliman, Saied M.;Haukka, Matti;Al-Shaalan, Nora Hamad;Alkharboush, Aminah A.;Barakat, Assem. And the article was included in ACS Omega in 2022.Category: thiazolidine This article mentions the following:

A new series of spirooxindoles I [X = S, H₂C; R = 6-Cl, 5-O₂N; R¹ = 2-Cl, 4-Cl; R² = Br, O₂N], II [R³ = Br, O₂N] and III based on ethylene derivatives having furan aryl moiety were reported. The new hybrids I, II and III were achieved via [3 + 2] cycloaddition reaction as an economic one-step efficient approach. The final constructed spirooxindoles I, II and III have four contiguous asym. carbon centers. The structure of IV [R⁴ = Br, R⁵ = 4-Cl] was exclusively confirmed using X-ray single crystal diffraction. The supramol. structure of IV [R⁴ = Br, R⁵ = 4-Cl] was controlled by O···H, H···H, and C···C intermol. contacts. It includes layered mols. interconnected weak C-H···O (2.675 Å), H···H (2.269 Å), and relatively short Cl···Br interhalogen interactions [3.4500(11)Å]. Using Hirshfeld anal., the percentages of these intermol. contacts were 10.6, 25.7, 6.4, and 6.2%, resp. The spirooxindoles along with ethylene derivatives having furan aryl moiety were assessed against breast (MCF7) and liver (HepG2) cancer cell lines. The results indicated that the new chalcone IV [R⁴ = Br, R⁵ = 2-Cl] showed excellent activity in both cell lines (MCF7 and HepG2) with IC₅₀ = 4.1 ± 0.10μM/mL (MCF7) and 3.5 ± 0.07μM/mL (HepG2) compared to staurosporine with 4.3 and 2.92 folds. Spirooxindoles II [R³ = Br] (IC₅₀ = 4.3 ± 0.18μM/mL), I [X = S, R = 6-Cl, R¹ = 2-Cl, R² = Br] (IC₅₀ = 10.3 ± 0.40μM/mL), I [X = H₂C, R = 6-Cl, R¹ = 4-Cl, R² = O₂N] (IC₅₀ = 10.7 ± 0.38μM/mL), and II [R³ = O₂N] (IC₅₀ = 4.7 ± 0.18μM/mL) exhibited potential activity against breast adenocarcinoma, while compounds II [R³ = Br] (IC₅₀ = 6.9 ± 0.23μM/mL) and I [X = S, R = 6-Cl, R¹ = 2-Cl, R² = Br] (IC₅₀ = 3.5 ± 0.11μM/mL) were the most active hybrids against human liver cancer cell line (HepG2) compared to staurosporine [IC₅₀ = 17.8 ± 0.50μM/mL (MCF7) and 10.3 ± 0.23μM/mL (HepG2)]. Mol. docking study exhibited the virtual mechanism of binding of compound IV [R⁴ = Br, R⁵ = 2-Cl] as a dual inhibitor of EGFR/CDK-2 proteins, and this may highlight the mol. targets for its cytotoxic activity. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Category: thiazolidine).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Open-chain compounds are obtained when thiazolidines are treated with tris(trimethylsilyl)silane in a reaction in which the thiazolidine derivatives act as a source of α-aminoalkyl radicals.Category: thiazolidine

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

The synthetic elicitor 2-(5-bromo-2-hydroxy-phenyl)-thiazolidine-4-carboxylic acid links plant immunity to hormesis was written by Rodriguez-Salus, Melinda;Bektas, Yasemin;Schroeder, Mercedes;Knoth, Colleen;Vu, Trang;Roberts, Philip;Kaloshian, Isgouhi;Eulgem, Thomas. And the article was included in Plant Physiology in 2016.Formula: C4H7NO2S This article mentions the following:

Here, we report on the characterization of one of these compounds, 2-(5-bromo-2-hydroxy-phenyl)-thiazolidine-4-carboxylic acid (BHTC). BHTC induces disease resistance of plants against bacterial, oomycete, and fungal pathogens and has a unique mode of action and structure. Surprisingly, we found that low doses of BHTC enhanced root growth in Arabidopsis, while high doses of this compound inhibited root growth, besides inducing defense. These effects are reminiscent of the hormetic response, which is characterized by low-dose stimulatory effects of a wide range of agents that are toxic or inhibitory at higher doses. Like its effects on defense, BHTC-induced hormesis in Arabidopsis roots is partially dependent on the WRKY70 transcription factor. Interestingly, BHTC-induced root hormesis is also affected in the auxin-response mutants axr1-3 and slr-1. By mRNA sequencing, we uncovered a dramatic difference between transcriptional profiles triggered by low and high doses of BHTC. Instead, low BHTC levels trigger a coordinated intercompartmental transcriptional response manifested in the suppression of photosynthesis- and respiration-related genes in the nucleus, chloroplasts, and mitochondria as well as the induction of development-related nuclear genes. Taken together, our functional characterization of BHTC links defense regulation to hormesis and provides a hypothetical transcriptional scenario for the induction of hormetic root growth. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Formula: C4H7NO2S).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Formula: C4H7NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com