Tag: 133.1689

Transformation between 2-Threityl-thiazolidine-4-carboxylic Acid and Xylose-Cysteine Amadori Rearrangement Product Regulated by pH Adjustment during High-Temperature Instantaneous Dehydration was written by Zhai, Yun;Cui, Heping;Hayat, Khizar;Hussain, Shahzad;Tahir, Muhammad Usman;Deng, Shibin;Zhang, Qiang;Zhang, Xiaoming;Ho, Chi-Tang. And the article was included in Journal of Agricultural and Food Chemistry in 2020.Reference of 444-27-9 This article mentions the following:

2-Threityl-thiazolidine-4-carboxylic acid (TTCA) was found to be the predominant product rather than the Amadori rearrangement product (ARP) during the formation of xylose-cysteine-derived (Xyl-Cys-derived) Maillard reaction intermediates (MRIs) through a thermal reaction coupled with vacuum dehydration. To regulate the existence forms of Xyl-Cys-derived MRIs, an effective method carried out by pH adjustment during high-temperature instantaneous dehydration through spray-drying was proposed in this research to promote the conversion from TTCA to ARP. The increased inlet air temperature of spray-drying could properly facilitate the shift of chem. equilibrium between the MRIs and promote the transformation from TTCA to ARP while raising the total yield of TA (TTCA + ARP). The conversion to ARP was increased to 20.83% at 190°C of hot blast compared to the product without spray-drying (6.03%). The conversion from TTCA to ARP was further facilitated in the pH range of 7.5-9.5. When the pH of the aqueous reactants was adjusted to 9.5, the equilibrium conversion to ARP was improved to 47.23% after spray-drying, which accounted for 59.48% of the TA formation. Accordingly, MRIs with different TTCA/ARP proportions could be selectively obtained by pH adjustment of the stock solution during high-temperature instantaneous dehydration of spray-drying. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Reference of 444-27-9).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Reference of 444-27-9

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides was written by Hartman, Matthew C. T.;Josephson, Kristopher;Lin, Chi-Wang;Szostak, Jack W.. And the article was included in PLoS One in 2007.Formula: C4H7NO2S This article mentions the following:

The application of in vitro translation to the synthesis of unnatural peptides may allow the production of extremely large libraries of highly modified peptides, which are a potential source of lead compounds in the search for new pharmaceutical agents. The specificity of the translation apparatus, however, limits the diversity of unnatural amino acids that can be incorporated into peptides by ribosomal translation. We have previously shown that over 90 unnatural amino acids can be enzymically loaded onto tRNA. We have now used a competition assay to assess the efficiency of tRNA-aminoacylation of these analogs. We have also used a series of peptide translation assays to measure the efficiency with which these analogs are incorporated into peptides. The translation apparatus tolerates most side chain derivatives, a few α,α disubstituted, N-Me and α-hydroxy derivatives, but no β-amino acids. We show that over 50 unnatural amino acids can be incorporated into peptides by ribosomal translation. Using a set of analogs that are efficiently charged and translated we were able to prepare individual peptides containing up to 13 different unnatural amino acids. Our results demonstrate that a diverse array of unnatural building blocks can be translationally incorporated into peptides. These building blocks provide new opportunities for in vitro selections with highly modified drug-like peptides. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Formula: C4H7NO2S).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine is an important scaffold and has a wide range of promising biological activities. Thiazolidine derivatives have reported anti-inflammatory and anti-nociceptive activity. Thiazolidines unsubstituted on the nitrogen atom are readily hydrolyzed by boiling aqueous solutions of acids or bases and the dissociation is complete in the presence of a compound reacting with one of the cleavage products.Formula: C4H7NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Spectrophotometric and spectrofluorimetric determination of mesna, acetylcysteine and timonacic acid through the reaction with acetoxymercuri fluorescein was written by Haggag, Rim S.;Gawad, Dina A.;Belal, Saeid F.;Elbardisy, Hadil M.. And the article was included in Analytical Methods in 2016.COA of Formula: C4H7NO2S This article mentions the following:

Simple, sensitive and specific spectrophotometric (Method I) and spectrofluorimetric (Method II) methods were developed for the determination of three sulfur-containing drugs: mesna (MSN), acetylcysteine (ACT) and timonacic acid (TMN). The methods are based on the suppressive effect of the drugs on the absorbance and the fluorescence intensity of 2′,7′-bis(acetoxymercuri)fluorescein (AMF) in 0.05 M borate buffer. In Method I the decrease in AMF absorbance was measured at 497 nm, while in Method II the fluorescence quenching of the reagent was measured at λ_em 520 nm (λ_ex 497 nm). All the exptl. parameters affecting this reaction were studied and optimized. The selectivity and the stability-indicating aspect of the methods were confirmed and no interference was detected from the oxidation products of the quantified drugs or from other co-administered drugs. Method I was applicable over the concentration ranges 0.5-3, 0.5-2.75 and 0.25-2.75 μg mL^-1 for MSN, ACT and TMN, resp. The reaction sensitivity was enhanced by Method II where the linearity ranges were found to be 0.6-7.2, 0.7-7 and 0.8-10.4 ng mL^-1 for MSN, ACT and TMN, resp. Both methods were applied for the determination of the three drugs in bulk form and in their pharmaceutical preparations without interference from common excipients. The percentage recoveries were satisfactory and they were statistically compared with those obtained from previously reported methods. Moreover, Method II was extended to analyze the drugs in spiked human plasma, by virtue of its high sensitivity. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9COA of Formula: C4H7NO2S).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.COA of Formula: C4H7NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Regioselective Synthesis of Carbazole-Grafted Dispirothiapyrrolizine Derivatives via 1,3-Dipolar Cycloaddition Strategy was written by Murali, Karunanidhi;Sparkes, Hazel A.;Prasad, Karnam Jayarampillai Rajendra. And the article was included in ChemistrySelect in 2019.Name: Thiazolidine-4-carboxylic acid This article mentions the following:

A library of dispirooxindole-thiapyrrolizine derivatives I [R = H, Me, Cl, R¹ = Ph, 2-thienyl, 4-MeOC₆H₄] were prepared via 1,3-dipolar cycloaddition of an azomethine ylide, generated in-situ from the reaction of isatin and thioproline, with a series of 2-arylidene/heteroarylidene-2,3,4,9-tetrahydrocarbazol-1-ones. Moderate to good yields were obtained for these reactions and also for spiro compounds of acenaphthenequinone, II [R² = H, Me, Cl, R³ = Ph, 2-thienyl], obtained using the same optimized reaction conditions. The structures of the spiro compounds I and II were established by FTIR, ¹H NMR, ¹³C NMR and elemental anal. The regio- and stereochem. of the spiranic adducts were ascertained by single crystal X-ray diffraction studies. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Name: Thiazolidine-4-carboxylic acid).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Name: Thiazolidine-4-carboxylic acid

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

A metabolomics approach identified toxins associated with uremic symptoms in advanced chronic kidney disease was written by Hu, Jiun-Ruey;Myint, Leslie;Levey, Andrew S.;Coresh, Josef;Inker, Lesley A.;Grams, Morgan E.;Guallar, Eliseo;Hansen, Kasper D.;Rhee, Eugene P.;Shafi, Tariq. And the article was included in Kidney International in 2022.Reference of 444-27-9 This article mentions the following:

Uremic symptoms are common in patients with advanced chronic kidney disease, but the toxins that cause these symptoms are unknown. To evaluate this, we performed a cross-sectional study of the 12 mo post-randomization follow-up visit of Modification of Diet in Renal Disease (MDRD) participants reporting uremic symptoms who also had available stored serum. We quantified 1,163 metabolites by liquid chromatog.-tandem mass spectrometry. For each uremic symptom, we calculated a score as the severity multiplied by the number of days the symptom was experienced. We analyzed the associations of the individual symptom scores with metabolites using linear models with empirical Bayesian inference, adjusted for multiple comparisons. Among 695 participants, the mean measured glomerular filtration rate (mGFR) was 28 mL/min/1.73 m². Uremic symptoms were more common in the subgroup of 214 patients with an mGFR under 20 mL/min/1.73 m² (mGFR under 20 subgroup) than in the full group. For all metabolites with significant associations, the direction of the association was concordant in the full group and the subgroup. For gastrointestinal symptoms (bad taste, loss of appetite, nausea, and vomiting), eleven metabolites were associated with symptoms. For neurol. symptoms (decreased alertness, falling asleep during the day, forgetfulness, lack of pep and energy, and tiring easily/weakness), seven metabolites were associated with symptoms. Associations were consistent across sensitivity analyses. Thus, our proof-of-principle study demonstrates the potential for metabolomics to understand metabolic pathways associated with uremic symptoms. Larger, prospective studies with external validation are needed. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Reference of 444-27-9).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Reference of 444-27-9

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Combined nitrogen limitation and cadmium stress stimulate total carbohydrates, lipids, protein and amino acid accumulation in Chlorella vulgaris (Trebouxiophyceae) was written by Chia, Mathias Ahii;Lombardi, Ana Teresa;da Graca Gama Melao, Maria;Parrish, Christopher C.. And the article was included in Aquatic Toxicology in 2015.Product Details of 444-27-9 This article mentions the following:

Metals have interactive effects on the uptake and metabolism of nutrients in microalgae. However, the effect of trace metal toxicity on amino acid composition of Chlorella vulgaris as a function of varying nitrogen concentrations is not known. In this research, C. vulgaris was used to investigate the influence of cadmium (10^-7 and 2.0 × 10^-8 mol L^-1 Cd) under varying nitrogen (2.9 × 10^-6, 1.1 × 10^-5 and 1.1 × 10^-3 mol L^-1 N) concentrations on its growth rate, biomass and biochem. composition Total carbohydrates, total proteins, total lipids, as well as individual amino acid proportions were determined The combination of Cd stress and N limitation significantly inhibited growth rate and cell d. of C. vulgaris. However, increasing N limitation and Cd stress stimulated higher dry weight and chlorophyll a production per cell. Furthermore, biomols. like total proteins, carbohydrates and lipids increased with increasing N limitation and Cd stress. Ketogenic and glucogenic amino acids were accumulated under the stress conditions investigated in the present study. Amino acids involved in metal chelation like proline, histidine and glutamine were significantly increased after exposure to combined Cd stress and N limitation. We conclude that N limitation and Cd stress affects the physiol. of C. vulgaris by not only decreasing its growth but also stimulating biomol. production In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Product Details of 444-27-9).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Product Details of 444-27-9

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

N-(β-Mercapto)arylamines in the synthesis of 2-acyl-3- arylthiazolidines and 3-arylthiazolidine-2-carbonic acids was written by Yur’ev, Yu. K.;Dyatlovitskaya, S. V.. And the article was included in Khimicheskaya Nauka i Promyshlennost in 1957.Application In Synthesis of Thiazolidine-2-carboxylic acid This article mentions the following:

Heating 0.01 mole N-(β-mercaptoethyl)aniline (I) with 0.03 mole methylglyoxal (II) in 8 ml. EtOH and decomposing with ice gave 96% 2-acetyl-3-phenylthiazolidine, m. 57.5-8° (80% EtOH). The 2-Bz derivative was obtained in 100% yield by treating with 0.04 mole phenylglyoxal instead of with II. A mixture of 0.5 mole I, 0.09 mole CHCl₂CO₂H, 0.09 mole anhydrous AcONa, and 0.1 mole Na₂CO₃ in 50 ml. absolute EtOH boiled 4 hrs., the EtOH distilled, and the residue treated with N HCl and EtOH yielded 50% 3-phenylthiazolidine-2-carboxylic acid; amide, m. 171-2° (decomposition) (EtOH); Et ester, b₂ 163-4°; hydrazide, m. 135-6° (H₂O). In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Application In Synthesis of Thiazolidine-2-carboxylic acid).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidines unsubstituted on the nitrogen atom are readily hydrolyzed by boiling aqueous solutions of acids or bases and the dissociation is complete in the presence of a compound reacting with one of the cleavage products.Application In Synthesis of Thiazolidine-2-carboxylic acid

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Stereoselective synthesis of dispiro heterocycles by [3 + 2] cycloaddition of azomethine ylides with a thiazolo[3,2-a]indole derivative was written by Sathi, Vidya;Thomas, Noble V.;Deepthi, Ani. And the article was included in Organic & Biomolecular Chemistry in 2020.Related Products of 444-27-9 This article mentions the following:

A green one pot three component [3 + 2] cycloaddition of a thiazolo[3,2-a]indole derivative (generated by the reaction of thieno[2,3-b]indole-2,3-dione and di-Me acetylenedicarboxylate) with isatin derived azomethine ylides was reported. An eco-friendly acetyl choline iodide-ethylene glycol (ACI/EG)-mediated deep eutectic solvent system was adopted for the reaction. Spiropyrrolidine oxindoles incorporating multiple stereocenters were obtained in a highly diastereoselective manner in excellent yields. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Related Products of 444-27-9).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Open-chain compounds are obtained when thiazolidines are treated with tris(trimethylsilyl)silane in a reaction in which the thiazolidine derivatives act as a source of α-aminoalkyl radicals.Related Products of 444-27-9

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

The effect of the administration of compounds which contain a sulfhydryl group on the survival rates of mice, rats, and guinea pigs was written by Oeriu, Simion;Vochitu, Elena. And the article was included in Journals of Gerontology in 1965.Related Products of 16310-13-7 This article mentions the following:

Subcutaneous injections (21) of either cysteine (30 mg./kg.) or thiazolidinecarboxylic acid (30 mg./kg.) and folic acid (0.75 mg./ kg.) into 12-month-old laboratory animals increased the survival rates of male mice and female guinea pigs but not of female rats. Body weight increases were observed in mice and guinea pigs but not in rats. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Related Products of 16310-13-7).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Open-chain compounds are obtained when thiazolidines are treated with tris(trimethylsilyl)silane in a reaction in which the thiazolidine derivatives act as a source of α-aminoalkyl radicals.Related Products of 16310-13-7

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Peroxisomal oxidation of thiazolidine carboxylates in firefly fat body, frog retina, and rat liver and kidney was written by St. Jules, Robert;Kennard, Jay;Setlik, Wanda;Holtzman, Eric. And the article was included in European Journal of Cell Biology in 1991.Product Details of 16310-13-7 This article mentions the following:

The D-amino acid oxidase is a widely distributed peroxisomal enzyme whose principal natural substrates are still unknown. Thiazolidine carboxylates, their derivatives and relatives, and the intermediates in their metabolism are among the more plausible substrate candidates. Using a cytochem. procedure, the authors explored the distribution of peroxide-generating enzymic activity against two thiazolidine carboxylates. These compounds are effective substrates for peroxisomal oxidation in a variety of tissues that contain peroxisomal D-amino acid oxidase. Reaction was seen in the classical peroxisomes of rat liver and kidney, the peroxisomes of the fat body of firefly and of Drosophila, and the peroxisomes of frog retina. Both with the thiazolidine compounds and with more traditional D-amino acid oxidase substrates, the fireflies’ photocycle granules, which are peroxisomes, lack activity. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Product Details of 16310-13-7).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Product Details of 16310-13-7

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com