Tag: 133.1689

Molecular diversity of the three-component reaction of α-amino acids, dialkyl acetylenedicarboxylates and N-substituted maleimides was written by Chen, Liang;Sun, Jing;Xie, Ju;Yan, Chao-Guo. And the article was included in Organic & Biomolecular Chemistry in 2016.Computed Properties of C4H7NO2S This article mentions the following:

The one-pot three-component reaction of secondary α-amino acids, including proline, thiazolidine-4-carboxylic acid, piperidine-2-carboxylic acid and sarcosine with dialkyl acetylenedicarboxylate and N-substituted maleimides in refluxing ethanol afforded functionalized pyrrolo[3,4-a]pyrrolizines, pyrrolo[3′,4′:3,4]pyrrolo[1,2-c]thiazoles, pyrrolo[3,4-a]indolizines and octahydropyrrolo[3,4-c]pyrroles in good yields and with high diastereoselectivity. On the other hand, the similar three-component reaction containing primary α-amino acids, such as glycine, alanine, phenylalanine and leucine, with N-substituted maleimides and two mols. of dialkyl acetylenedicarboxylate gave the corresponding (hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)maleates. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Computed Properties of C4H7NO2S).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Computed Properties of C4H7NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder was written by Umehara, Hidehiro;Numata, Shusuke;Watanabe, Shin-ya;Hatakeyama, Yutaka;Kinoshita, Makoto;Tomioka, Yukiko;Nakahara, Kiyoshi;Nikawa, Takeshi;Ohmori, Tetsuro. And the article was included in Scientific Reports in 2017.COA of Formula: C4H7NO2S This article mentions the following:

Capillary electrophoresis-time-of-flight mass spectrometry (CE-TOFMS) is a comprehensive, quant., and high throughput tool used to analyze metabolite profiles. In the present study, we used CE-TOFMS to profile metabolites found in the blood plasma of 33 medication-free patients with major depressive disorder (MDD) and 33 non-psychiatric control subjects. We then investigated changes which occurred in the metabolite levels during an 8-wk treatment period. The medication-free MDD patients and control subjects showed significant differences in their mean levels of 33 metabolites, including kynurenine (KYN), glutamate (Glu), glutamine (Gln), methionine sulfoxide, and methionine (Met). In particular, the ratios of KYN to tryptophan (TRP), Gln to Glu, and Met to methionine sulfoxide were all significantly different between the two groups. Among the 33 metabolites with altered levels in MDD patients, the levels of KYN and Gln, as well as the ratio of Gln to Glu, were significantly normalized after treatment. Our findings suggest that imbalances in specific metabolite levels may be involved in the pathogenesis of MDD, and provide insight into the mechanisms by which antidepressant agents work in MDD patients. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9COA of Formula: C4H7NO2S).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. COA of Formula: C4H7NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Thiaproline and selenaproline transport in E. coli was written by Di Girolamo, Mario;Cini, Chiara;Busiello, Vincenzo;Coccia, Raffaella;De Marco, Carlo. And the article was included in Physiological Chemistry and Physics and Medical NMR in 1984.SDS of cas: 16310-13-7 This article mentions the following:

The proline transport system in Escherichia coli KL16 was studied. Its K_m is 0.5 μM, and this value is not affected by the presence of glucose nor by pH variations in the range 5.5-8. The proline transport is inhibited by β- and γ-thiaproline, and β- and γ-selenaproline, proline isologs with the methylene group in β or in γ position substituted by an S or Se. The inhibition is of the competitive type and pH-dependent. The K_i values show that all isologs have an affinity for the transport system that is much lower than that of proline; selena isologs have lower affinity than thia isologs. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7SDS of cas: 16310-13-7).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.SDS of cas: 16310-13-7

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Ethyl lactate mediated 1,3-dipolar cycloaddition of azomethine ylides: a design, synthesis and antibacterial activity of novel dispiro heterocycles was written by Sharma, Kanti;Sharma, Lokesh K.;Jain, Meenakshi;Jain, Renuka. And the article was included in Chemistry & Biology Interface in 2018.Related Products of 444-27-9 This article mentions the following:

A facile, greener and efficient one-pot, three-component procedure for the synthesis of novel dispirooxindolopyrrolothiazole derivatives carried out by cycloaddition reaction of 3-methyl-1-phenyl-4-thiophenylidene-5-pyrazolone dipolarophile, azomethine ylides generated in-situ, via decarboxylative condensation of isatin with thiazolidine-4-carboxylic acid was reported using Et lactate as a recyclable solvent in excellent yield without using any catalyst. This green route provided mild reaction conditions, high yields of products in short reaction time, high regio- and stereoselectivity, operational simplicity and environmentally benign synthesis. The synthesized compounds were characterized by anal. and spectral (IR, ¹H-NMR, ¹³C-NMR and FAB mass) data. All synthesized compounds were screened for antibacterial activity against B. subtilis, S. aureus, E. coli and P. aeruginosa bacteria. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Related Products of 444-27-9).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine is an important scaffold and has a wide range of promising biological activities. Thiazolidine derivatives have reported anti-inflammatory and anti-nociceptive activity. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Related Products of 444-27-9

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Derivatives of 2-thiazolidinecarboxylic acid was written by Pazenko, Z. N.. And the article was included in Ukrains’kii Khemichnii Zhurnal in 1958.Recommanded Product: Thiazolidine-2-carboxylic acid This article mentions the following:

(EtO)₂CHCO₂H (I) and H₂N(CH₂)₂SH, m. 97°, (from (CH₂)₂NH and H₂S) form in EtOH 2-thiazolidinecarboxylic acid (II), decompose 203°. The Et ester of I forms similarly that of II, m. 37°, HCl salt m. 207-9°, and an unidentified compound, 9.36% N, m. 230°. Cl₂CHCO₂Me forms the Me ester of II, b₄ 8.9°, m. 25°. II, (CH₂)₂O, and BF₃ in Et₂O form 3-β-hydroxyethyl-2-thiazolidinecarboxylic acid δ-lactone, m. 87-9°. MeCOCO₂H and MeCOCO₂Et and H₂N(CH₂)₂SH form the 2-Me derivative of II and its Et ester, m. 192-5° and b₄ 72-5°, resp. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Recommanded Product: Thiazolidine-2-carboxylic acid).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Recommanded Product: Thiazolidine-2-carboxylic acid

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Ethyl 6′-cyano-7′-phenyl-1′,6′,7′,7a′-tetrahydro-3′H-spiro[indeno[1,2-b]quinoxaline-11,5′-pyrrolo[1,2-c]thiazole-6′-carboxylate was written by Muthuselvi, C.;Athimoolam, S.;Srinivasan, N.;Ravikumar, B.;Pandiarajan, S.;Krishnakumar, R. V.. And the article was included in IUCrData in 2018.Formula: C4H7NO2S This article mentions the following:

In the title compound, C22H22ClN4O2S, the angle between the mean planes of the indene ring and the quinoxaline ring system is 3.93 (11)°. The five-membered indene and thiazole rings both adopt envelope conformations while the pyrrole ring adopts a twisted conformation. The two acceptor O atoms form a chelated three-centered hydrogen bond with a Ph C atom. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Formula: C4H7NO2S).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Formula: C4H7NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Assessment of the effects of repeated freeze thawing and extended bench top processing of plasma samples using untargeted metabolomics was written by Goodman, Kelli;Mitchell, Matthew;Evans, Anne M.;Miller, Luke A. D.;Ford, Lisa;Wittmann, Bryan;Kennedy, Adam D.;Toal, Douglas. And the article was included in Metabolomics in 2021.Reference of 444-27-9 This article mentions the following:

Introduction: Clin. metabolomics has utility as a screen for inborn errors of metabolism (IEM) and variant classification in patients with rare disease. It is important to understand and characterize preanal. factors that influence assay performance during patient sample testing. Objectives: To evaluate the impact of extended thawing of human EDTA plasma samples on ice prior to extraction as well as repeated freeze-thaw cycling of samples to identify compounds that are unstable prior to metabolomic anal. Twenty-four (24) donor EDTA plasma samples were collected and immediately frozen at – 80 °C. Twelve samples were thawed on ice and extracted for anal. at time 0, 2, 4, and 6 h. Twelve other donor samples were repeatedly thawed and frozen up to four times and analyzed at each cycle. Compound levels at each time point/freeze-thaw cycle were compared to the control samples using matched-paired t tests to identify analytes affected by each condition. We identified 1026 biochems. across all samples. Incubation of thawed EDTA plasma samples on ice for up to 6 h resulted in < 1% of biochems. changing significantly. Freeze-thaw cycles affected a greater percentage of the metabolome; ∼ 2% of biochems. changed after 3 freeze-thaw cycles. Our study highlights that the number and magnitude of these changes are not as widespread as other aspects of improper sample handling. In total, < 3% of the metabolome detected on our clin. metabolomics platform should be disqualified when multiple freeze-thaw cycles or extended thawing at 4 °C are performed on a given sample. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Reference of 444-27-9).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Reference of 444-27-9

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Metabolomics analysis of blood identifies potential biomarkers and possible treatment targets for nocturia was written by Kira, Satoru;Mitsui, Takahiko;Miyamoto, Tatsuya;Ihara, Tatsuya;Nakagomi, Hiroshi;Hashimoto, Yuka;Takamatsu, Hajime;Tanahashi, Masayuki;Takeda, Masahiro;Sawada, Norifumi;Takeda, Masayuki. And the article was included in Therapeutic Advances in Urology in 2019.Name: Thiazolidine-4-carboxylic acid This article mentions the following:

Background:: Our aim was to investigate the association between serum metabolites and nocturia. Methods:: A total of 66 males aged 65-80 years were enrolled in this study and stratified according to micturition behavior, which was characterized in terms of the 24 h frequency volume chart (FVC) for 3 consecutive days, the International Prostate Symptom Score (IPSS), and quality-of-life score. Between-group comparisons of metabolite levels employed the Welch t test. The relationship between nocturia and metabolite profiles was determined using multivariable logistic regression anal. Results:: Of 66 participants, 45 were included in the nocturia group and 21 in the control group. There were no differences in background factors between the two groups. FVC anal. revealed that urine production during night-time, as well as micturition frequency during daytime and night-time were significantly higher in the nocturia group. CE-TOFMS identified eight metabolites whose plasma levels differed between the two groups. Multivariate anal. indicated that increased levels of lauric acid and imidazolelactic acid, as well as decreased levels of thiaproline and glycerol, contribute to the etiol. of nocturia in aged men. Conclusions:: Our findings suggest that abnormal serum levels of metabolites in several pathways play a role in the pathogenesis of nocturia in aged men. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Name: Thiazolidine-4-carboxylic acid).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidine is prepared as it was in its first reported synthesis, by the condensation of cysteamine and formaldehyde. Other thiazolidines may be synthesized by similar condensations. A notable derivative is 4-carboxythiazolidine, derived from formaldehyde and cysteine.Name: Thiazolidine-4-carboxylic acid

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Metabolomic analysis of diet-induced obese mice supplemented with eicosapentaenoic acid was written by Nishitani, Shigeki;Fukuhara, Atsunori;Jinno, Yasutaka;Kawano, Hiroyuki;Yano, Takashi;Otsuki, Michio;Shimomura, Iichiro. And the article was included in Experimental and Clinical Endocrinology & Diabetes in 2020.Electric Literature of C4H7NO2S This article mentions the following:

Eicosapentaenoic acid (EPA) is an omega-3 fatty acid with anti-inflammatory effects. To determine the effects of EPA on metabolic pathways in obese adipose tissues and liver, mice were fed normal chow diet (NCD), high-fat diet (HFD), or 3% EPA-containing high fat diet (HFD+EPA) for 8 wk. Metabolomic anal. was performed using epididymal adipose tissues (epi WAT) and liver. Metabolites that were specifically elevated in HFD+EPA, were assessed for their anti-inflammatory properties using RAW264.7 macrophage cells. Body and adipose tissue weights were significantly higher in HFD than NCD, and lower in HFD+EPA than HFD. Plasma insulin levels were significantly higher in HFD than NCD, and lower in HFD+EPA compared with HFD. Plasma monocyte chemotactic protein-1 (MCP-1) levels were higher in HFD than NCD, and tended to be lower in HFD+EPA than HFD. The levels of intermediate metabolites in the glycolytic pathways were lower in HFD compared with NCD and HFD+EPA in both epi WAT and liver, while intermediate metabolites of the TCA cycles were elevated in HFD and HFD+EPA compared with NCD in epi WAT. Among the metabolites in epi WAT, the levels of thiaproline, phenaceturic acid, and pipecolic acid were specifically elevated in HFD+EPA, but not in HFD or NCD. Treatment of RAW264.7 cells with thiaproline significantly ameliorated LPS-induced iNOS expression, while pipecolic acid inhibited LPS-induced IL-1β expression. These results suggest that EPA normalizes glycolytic pathway intermediates in both epi WAT and liver, and induces metabolites with anti-inflammatory properties. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Electric Literature of C4H7NO2S).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Electric Literature of C4H7NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

1,3-Dipolar cycloaddition reaction on carbohydrate template: Stereoselective synthesis of glyco-spiro-heterocycles was written by Prasanna, R.;Purushothaman, S.;Raghunathan, R.. And the article was included in Tetrahedron in 2020.Synthetic Route of C4H7NO2S This article mentions the following:

A simple and an efficient stereoselective synthesis of glyco-spiro-heterocycles has been accomplished via 1, 3-dipolar cycloaddition (1,3-DC) reaction. The azomethine ylide generated by decarboxylative condensation of N-alkylated α-amino acids with various diketones was trapped by sugar derived dipolarophiles to give glyco-spiro-heterocycles in good yield (72-94%). All the cycloadducts were well characterized by FT IR, NMR, HRMS and HPLC. The structures were established by 2D NMR. The regio- and stereochem. outcome of some of the cycloadducts were confirmed by a single crystal X-ray anal. Effect of various solvents on 1, 3 DC reaction was also studied. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Synthetic Route of C4H7NO2S).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Synthetic Route of C4H7NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com