With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19771-63-2,(R)-2-Oxothiazolidine-4-carboxylic acid,as a common compound, the synthetic route is as follows.,19771-63-2
EXAMPLE 1 N-[Trans-4-nitroxymethylcyclohexylmethyl]-(4R)-2-oxothiazolidin-4-yl-carboxamide (Exemplary Compound No. 1-32) In 7 ml of dry benzene was suspended 0.35 g of (4R)-2-oxo-4-thiazolidinecarboxylic acid, and 0.42 ml of oxalyl chloride and a few drops of dimethylformamide were added thereto at room temperature and stirred at room temperature for 2 hours. The solvent was distilled off under reduced pressure to obtain the acid chloride as a pale yellow oil. Meanwhile, 0.51 g of trans-4-nitroxymethylcyclohexylmethylamine hydrochloride was suspended in 10 ml of dry dichloromethane, and 0.95 ml of triethylamine and 5 ml of a solution of the acid chloride in dry dichloromethane were added dropwise thereto with stirring under ice-cooling and stirred at the same temperature for 1 hour. The solvent was distilled off under reduced pressure. The residue was subjected to silica gel column chromatography employing ethyl acetate as an eluding solvent to separate and purify and crystallized from ether to obtain 0.30 g of the desired compound as a colorless crystalline solid. m.p.: 117-119 C. (decomp.); NMR spectrum (CDCl3 +d6 -DMSO) delta ppm: 0.90-1.15(4H,m), 1.40-1.60(1H,m), 1.60-1.95(5H,m), 3.14(2H,m), 3.60-3.78(2H,m), 4.20-4.38(3H,m), 7.10(1H,bs), 7.67(1H,bs)
As the paragraph descriping shows that 19771-63-2 is playing an increasingly important role.
Reference£º
Patent; Sankyo Company, Limited; US5843973; (1998); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com