It is a common heterocyclic compound, the thiazolidine compound, (S)-4-Benzylthiazolidine-2-thione, cas is 171877-39-7 its synthesis route is as follows.,171877-39-7
A solution cooled in an ice bath of (S)-4-benzylthiazolidin-2-thione (18.37g, 87.87mmol) in CH2Cl2 (266mL) was treated with Et3N (2 eq) and then with 4-phenylbutanoyl chloride (Intermediate XI.1, 114.23mmol). The resulting mixture was stirred at room temperature for 12 days and then quenched with brine and extracted with CH2Cl2, dried with Na2SO4, filtered and concentrated. Purification by silica gel chromatography using Hex:AcOEt mixtures of increasing polarity (95:5, 9:1, 8:2, 7:3 and 6:4) afforded 24g (70%) of a yellow oil. 13C-NMR (500MHz, CDCl3) delta 201.06, 173.73, 141.53, 136.56, 129.44, 128.88, 128.53, 128.36, 127.19, 125.96, 68.53, 37.93, 36.79, 35.11, 31.90, 26.43.
With the complex challenges of chemical substances, we look forward to future research findings about (S)-4-Benzylthiazolidine-2-thione
Reference£º
Patent; Universitat Jaume I; EP2168954; (2010); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com