With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.171877-39-7,(S)-4-Benzylthiazolidine-2-thione,as a common compound, the synthetic route is as follows.
Add 1000 ml of dichloromethane and 500 ml (3.6 mol) of triethylamine to a 5-liter four-necked flask.Benzylthiooxazolidinone 209g (1mol), phenylacetic acid 140g (1mol),300 g (1 mol) of 2-chloropyridine p-toluenesulfonic acid methyl salt was added dropwise1000 ml of methylene chloride solution, added, and stirred at 25 C for 5 hours.TLC showed complete reaction, adding water to extract the reaction, followed by water,The organic phase is washed with saturated brine, dried over anhydrous sodium sulfate and concentrated.Recrystallization gave 300 g of product with a yield of 91.7%.HPLC purity >99%., 171877-39-7
As the paragraph descriping shows that 171877-39-7 is playing an increasingly important role.
Reference£º
Patent; Shanghai Lark Pharmaceutical Technology Co., Ltd.; Shen Xin; Yang Jidong; Hu Xiaochuan; Li Feng; (6 pag.)CN109020913; (2018); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com