The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《A new pyrrole synthesis》. Authors are Fischer, Hans; Fink, Emmy.The article about the compound:Ethyl 3,5-Dimethyl-2-pyrrolecarboxylatecas:2199-44-2,SMILESS:O=C(C1=C(C)C=C(C)N1)OCC).Related Products of 2199-44-2. Through the article, more information about this compound (cas:2199-44-2) is conveyed.
Mutual reduction of isonitrosoacetoacetic ester or isonitrosobutyryl-acetic ester and AcCH2CH(OEt)2 (I) in the presence of Zn dust yielded 2-methyl-5-carbethoxypyrrole (II), m. 100°, subliming at 90° at 20 mm. On treatment with HCN and HCl in ether, II was converted to 2-methyl-5-carbethoxy-3-pyrrolecarboxaldehyde, m. 119°. I, heated with glacial AcOH for 1/2 h., yielded triacetylbenzene (III), m. 161°. In cold glacial AcOH, III was formed in only minimal amounts from I, but in considerable amounts from the Na salt of formylacetone. Acetylacetone was condensed with isonitrosoacetoacetic ester to form 2,4-dimethyl-3-acetyl-5-carbethoxypyrrole, and as a side-product, 2,4-dimethyl-5-carbethoxypyrrole, m. 123°. Glycine was condensed with AcCH2CHO, or with I, or with the Na salt of formylacetone, to yield a product, not yet isolated, giving a pos. Ehrlich reaction for pyrrole. These syntheses may be of physiol. importance in the formation of blood pigments.
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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com