5908-62-3, 1,1-Dioxo-isothiazolidine is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5908-62-3
EXAMPLE 9 STR38 Sodium hydride (1.25 g of a 50% dispersion in oil) was added at room temperature to a stirred solution of isothiazolidine-1,1-dioxide (2.42 g) in DMF (15 cm3). After stirring for 0.5 hours 2-methyl-2-[1-(6,7-dimethoxyquinazolin-4-yl)piperid-4-yl]oxirane (5.0 g) was added and the mixture was stirred for 4 hours at 100. Volatile material was removed in vacuo, the residue was partitioned between chloroform (100 cm3) and water (50 cm3) and the chloroform layer was dried (MgSO4) and evaporated. The residue was chromatographed on silica (“Merck” 60.9385) eluding with methanol:ethyl acetate, 1:4, to give a solid which was recrystallized from ethyl acetate-methanol to give 2-{2-hydroxy-2-[1-(6,7-dimethoxyquinazolin-4-yl)piperid-4-yl]prop-1-yl}isothiazolidine-1,1-dioxide, m.p. 173-174 (4.15 g). Analysis %: Found: C,55.6; H,6.8; N,12.4; Calculated for C21 H30 N4 O5 S: C,56.0; H,6.7; N,12.4.
As the paragraph descriping shows that 5908-62-3 is playing an increasingly important role.
Reference£º
Patent; Pfizer Inc.; US4542132; (1985); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com