Preparation of optically active 2-thiazolidinecarboxylic acid by asymmetric transformation was written by Shiraiwa, Tadashi;Katayama, Takashi;Ishikawa, Joji;Asai, Takeshi;Kurokawa, Hidemoto. And the article was included in Chemical & Pharmaceutical Bulletin in 1999.Application of 16310-13-7 This article mentions the following:
Cysteamine was condensed with glyoxylic acid monohydrate in a mixture of acetic acid and ethanol in the presence of (2R,3R)- or (2S,3S)-tartaric acid [(R)- or (S)-TA], as the resolving agent, to give the salt of (-)-2-thiazolidinecarboxylic acid [(-)-2-THC] with (R)-TA or the salt of (+)-2-THC with (S)-TA. Treatment of these salts with triethylamine in methanol afforded (-)- and (+)-2-THC, I and II resp. I and II were determined to be enantiopure forms by comparing their powder X-ray diffraction patterns with that of (RS)-2-THC. The absolute configurations of I and II were estimated based on molar rotations of (2R,4R)- and (2S,4R)-2,4-thiazolidinedicarboxylic acids, (R)-4-thiazolidinecarboxylic acid, and I and II. I was determined to have the (R)-configuration with II having the (S)-configuration. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Application of 16310-13-7).
Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine is an important scaffold and has a wide range of promising biological activities. Thiazolidine derivatives have reported anti-inflammatory and anti-nociceptive activity. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Application of 16310-13-7
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com