Ethyl lactate mediated 1,3-dipolar cycloaddition of azomethine ylides: a design, synthesis and antibacterial activity of novel dispiro heterocycles was written by Sharma, Kanti;Sharma, Lokesh K.;Jain, Meenakshi;Jain, Renuka. And the article was included in Chemistry & Biology Interface in 2018.Related Products of 444-27-9 This article mentions the following:
A facile, greener and efficient one-pot, three-component procedure for the synthesis of novel dispirooxindolopyrrolothiazole derivatives carried out by cycloaddition reaction of 3-methyl-1-phenyl-4-thiophenylidene-5-pyrazolone dipolarophile, azomethine ylides generated in-situ, via decarboxylative condensation of isatin with thiazolidine-4-carboxylic acid was reported using Et lactate as a recyclable solvent in excellent yield without using any catalyst. This green route provided mild reaction conditions, high yields of products in short reaction time, high regio- and stereoselectivity, operational simplicity and environmentally benign synthesis. The synthesized compounds were characterized by anal. and spectral (IR, 1H-NMR, 13C-NMR and FAB mass) data. All synthesized compounds were screened for antibacterial activity against B. subtilis, S. aureus, E. coli and P. aeruginosa bacteria. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Related Products of 444-27-9).
Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine is an important scaffold and has a wide range of promising biological activities. Thiazolidine derivatives have reported anti-inflammatory and anti-nociceptive activity. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Related Products of 444-27-9
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com