3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid, cas is 7025-19-6, it is a common heterocyclic compound, the thiazolidine compound, its synthesis route is as follows.,7025-19-6
General procedure: A mixture of the selected aldehyde (0.75 mmol), 3-(2?- hydroxycarbonylethyl)-2-thioxothiazolidin-4-one (0.75 mmol, 159 mg) and anhydrous sodium acetate (2.25 mmol, 187 mg) in glacial acetic acid (0.75 mL) was thoroughly mixed in an appropriate 10 mL thick-walled glass vial. This was tightly sealed with a Teflon cap and the reaction mixture was stirred and heated at 140 C for 5 minutes, under focused microwave irradiation, with an initial power setting of 75 W. After cooling to room temperature, the yellow solid that precipitated from the crude product mixture was washed with distilled water, filtered under reduced pressure, recrystallized from dichloromethane and dried at room temperature under vacuum, yielding the desired compound as a bright-yellow solid. See, e.g., Figure 1. Yield: 83%, 215 mg; mp (C): 216-217; FT-JR (v, cm?): 3512, 3012, 1691, 1585, 1520, 1441, 1429, 1386,1314, 1253, 1218, 1171, 1152, 1106, 1075, 1025, 1005, 993, 937, 916, 873, 845, 792,734, 710, 622, 597, 566, 557, 536, 500; UV-vis (CH3OH): Xfflax, nm (relative absorbance, = 283 (70.3), 388 (100), 453 (17.2); ?H NMR (400 MHz, (CD3)2SO/CCL): oe, ppm =7.67 (1H, s, CH), 7.19 (2H, d, J= 7.6 Hz, ArH), 4.27 (2H, t, J= 7.8 Hz,NCH2CH2CO2H), 2.61 (2H, t, J= 7.8 Hz, NCH2CH2CO2H); ?3C NMR (100 MHz,(CD3)2SO/CCL): oe,ppm= 191.9, 171.1, 166.3, 152.3 (dd,J= 243.3 and 7.6 Hz), 137.1(t, J= 16.1 Hz), 131.4, 122.9 (t, J= 8.6 Hz), 120.9, 113.9 (dd, J= 15.2 and 7.4 Hz), 39.7,30.6; HR-MS (EJ): mlz = 344.9946 (M, C,3H9F2N0452 required 344.9941).
With the rapid development of chemical substances, we look forward to future research findings about 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid
Reference£º
Patent; BSIM2 ? BIOMOLECULAR SIMULATIONS LDA; PONTES MEIRELES FERREIRA DE BRITO, Rui Manuel; VIEIRA SIMOES, Carlos Jose; DE VASCONCELOS DIAS DE PINHO MELO, Teresa Margarida; DA SILVA VICTOR, Bruno Lourenco; LOURENCO DE ALMEIDA, Zaida Catarina; CABRAL LOPES, Ana Lucia; OLIVEIRA NASCIMENTO, Bruno Filipe; (182 pag.)WO2016/80853; (2016); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com