Chemical engineers work across a number of sectors, processes differ within each of these areas, Synthetic Route of 2682-49-7, but chemistry and chemical engineering roles are found throughout, and are directly involved in the design, development, creation and manufacturing process of chemical products and materials. 2682-49-7, Name is Thiazolidin-2-one, molecular formula is C3H5NOS. In a Article，once mentioned of 2682-49-7
Background: Microtubules act as a useful and strategic molecular target for various anticancer drugs that binds to its distinct sites in tubulin subunits and inhibits its polymerization and ultimately leads to cell death. Moreover, numerous reports highlight the cytotoxic effects of constraint Combretastatin analogs and thiazolidinone derivatives. Objective: Therefore, the present study investigates the potential of thiazolidinone constraint combretastatin analogs as tubulin inhibitors. Method: By incorporating silica supported fluroboric acid, a series of thiazolidinone constraint combretastatin analogs were synthesized in a microwave reactor under solvent free conditions. To optimize the reaction conditions, the detailed investigation was done for the catalytic influence of HBF4-SiO2. All the synthesized analogs were assessed for in-vitro cytotoxicity against THP-1, COLO-205, HCT-116 and A-549 human cancer cell lines. Top hits were further examined for their tubulin polymerization inhibition and their effect on microtubule assembly. The significant cytotoxicity and tubulin polymerization inhibition of the most potent structure was further rationalized by molecular modelling studies. Results: The results stated that CS-2, CS-3 and CS-20 possessed significant cytotoxic potential with the IC50 values ranging from 1.21 to 5.50 muM against THP-1, COLO-205, HCT-116 human cancer cell lines. Established structure activity relationship revealed that the nature of Ring A substantially influences the cytotoxic potential of the compounds. Placement of methoxy substituents on the phenyl ring (Ring A) was found to be the most preferred structural feature. Compound CS-2 was found to considerably inhibit the tubulin polymerization (IC50 value 2.12 muM) and caused disruption of microtubule assembly as demonstrated by immunoflourescence technique. In molecular modelling studies, CS-2 exhibited various hydrophobic as well as hydrogen bonding interactions at colchicine binding site and was found to be stabilized in this cavity. Conclusion: This work provides an efficient methodology for the synthesis of antitubulin thiazolodinone- combretastatin hybrids.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 2682-49-7. In my other articles, you can also check out more blogs about 2682-49-7
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Quinuclidine – Wikipedia,
Quinuclidine | C7H448N | ChemSpider