Influence of substituents on the synthesis of thiazolidinones was written by Sahu, M.;Garnaik, B. K.;Behera, Rajani. And the article was included in Indian Journal of Chemistry in 1987.Safety of 3-Methylthiazolidine-2,4-dione This article mentions the following:
Unsym. thioureas R1NHCSNHR2 (R1 = arylthiazolyl, Ph, pyridyl, allyl, ClC6H4, O2NC6H4; R2 = allyl, Me, cyclohexyl, Ph, anisyl) were heated with ClCH2CO2H in EtOH to give iminothiazolidinones I. The addition reaction of R1NH2 with R2NCS gave the thioureas. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Safety of 3-Methylthiazolidine-2,4-dione).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Safety of 3-Methylthiazolidine-2,4-dione
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com