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To develop an orally active, long-acting nitrate that does not induce tolerance, nitroxyalkyl compounds were prepared and their activities evaluated by the use of carotid collaterals in anesthetized dogs. A compound having a favorable pharmacological profile, that is, long-lasting collateral vasodilatation and little hypotension, and lack of nitrate tolerance, was chosen for further evaluation.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Safety of (R)-2-Oxothiazolidine-4-carboxylic acid, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 19771-63-2
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Quinuclidine – Wikipedia,
Quinuclidine | C7H670N | ChemSpider