The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: tert-Butyl (6-chloropyridazin-3-yl)carbamate( cas:1276056-86-0 ) is researched.Application of 1276056-86-0.Neubert, Timothy D.; Schmidt, Yvonne; Conroy, Erica; Stamos, Dean published the article 《Radical Mediated C-H Functionalization of 3,6-Dichloropyridazine: Efficient Access to Novel Tetrahydropyridopyridazines》 about this compound( cas:1276056-86-0 ) in Organic Letters. Keywords: dichloropyridazine primary alc radical addition titanium trichloride tertbutyl hydroperoxide; chloropyridazinyl alkanol primary amine heterocyclization; tetrahydropyridopyridazine preparation mol crystal structure. Let’s learn more about this compound (cas:1276056-86-0).
A radical mediated C-H functionalization of 3,6-dichloropyridazine using primary alcs., t-BuOOH, and TiCl3 to access alkoxy pyridazines is described. This transformation is conducted open to air and on gram scale. A subsequent cyclization step can then be employed to efficiently access diversely substituted tetrahydropyridopyridazines, e.g., I (X-rays single crystal structure shown), with multiple functional handles.
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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com