Thiazolidinedione-Isatin Conjugates via an Uncatalyzed Diastereoselective Aldol Reaction on Water was written by Paladhi, Sushovan;Bhati, Meeta;Panda, Deepanjan;Dash, Jyotirmayee. And the article was included in Journal of Organic Chemistry in 2014.Safety of 3-Methylthiazolidine-2,4-dione This article mentions the following:
An uncatalyzed aldol reaction of N-substituted thiazolidinediones I (R = Me, Et, n-Bu, CH2Ph, Boc) with isatin derivatives II (R1 = Me, Et, Ph, CH2Ph, H, R2 = R3 = H; R1 H, R2 = Cl, Br, F, OCF3, R3 = H; R1 = H, R2 = R3 = Me) has been developed “on water” to afford a new class of pharmacol. important thiazolidinedione-isatin conjugates III in excellent yields and diastereoselectivities. The isatin-thiazolidine conjugate undergoes a catalyst-free stereoselective transfer aldol reaction on water. Single-crystal X-ray studies reveal that the aldol products can self-assemble to form supramol. DNA “zipper” like structures through intermol. hydrogen bonds and aromatic π-π interactions. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Safety of 3-Methylthiazolidine-2,4-dione).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidine is prepared as it was in its first reported synthesis, by the condensation of cysteamine and formaldehyde. Other thiazolidines may be synthesized by similar condensations. A notable derivative is 4-carboxythiazolidine, derived from formaldehyde and cysteine.Safety of 3-Methylthiazolidine-2,4-dione
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com