Heterocyclic Building Blocks-Thiazolidine

185137-29-5, (S)-4-Phenylthiazolidine-2-thione is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

b. 4-(S)-Phenyl-2-thione-thiazolidine-3-carboxylic acid-4-nitro-phenyl ester To a suspension of NaH (26 mg, 1.04 mmol) in 10 mL of anhydrous THF under argon, a solution of 4(S)-Phenyl-thiazolidine-2-thione (170 mg, 0.87 mmol) in THF was added dropwise via an dropping funnel. The resulting suspension was stirred at room temperature for 30 min. This suspension was then added dropwise via cannula into another round bottom flask containing a solution of 4-nitrophenylchloroformate (217 mg, 1.04 mmol) in 20 mL of THF and cooled at -78 C. over a period of 15 min. The stirring was continued for 2 h after which the solvent was removed and the residue was purified by column chromatography on silica gel with 1:1 hexane/CH2 Cl2 then 3:7 hexane/CH2 Cl2 followed by CH2 Cl2 (Rf =0.50) to obtain (+)-4(S)-phenyl-2-thione-thiazolidine-3-carboxylic acid-4-nitro-phenyl ester as a pale yellow solid (200 mg, 64%).

As the paragraph descriping shows that 185137-29-5 is playing an increasingly important role.

Reference£º
Patent; Synaptic Pharmaceutical Corporation; US6159990; (2000); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5908-62-3,1,1-Dioxo-isothiazolidine,as a common compound, the synthetic route is as follows.

To an oven dried 50 mE round-bottom flask, methyl2-bromo-5-methylbeioate (352 mg, 1.54 mmol), sultam(236 mg, 1.95 mmol), cesium carbonate (732 mg, 2.25mmol), palladium acetate (40.4 mg, 0.18 mmol), and Xanphos (136 mg, 0.23 5 mmol) were added and flask was placedunder argon. Reagents were suspended in 8 mE of anhydrousdioxane and mixture was heated at 100 C. overnight. Aftercooling to room temperature, reaction mixture was filtered,was1ng with ethyl acetate. Combined filtrate was concen446.04trated under reduced pressure and resulting film was purifiedby silica gel column chromatography (25-100% EthylAcetate in Hexanes) to yield intermediate 11.?H-NMR (DMSO, 400 MHz): oe 7.75 (d, 1H), 7.44 (m, 1H),7.35 (m, 1H), 3.89 (s, 3H), 3.81 (t, 2H), 3.28 (t, 2H), 2.55 (m,2H), 2.39 (s, 3H).ECMS m/z [M+H] C12H15N04S requires: 270.07. Found270.12.

As the paragraph descriping shows that 5908-62-3 is playing an increasingly important role.

Reference£º
Patent; Gilead Sciences, Inc.; Sangi, Michael; (125 pag.)US9278975; (2016); B2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.26364-65-8,2-Cyanoimino-1,3-thiazolidine,as a common compound, the synthetic route is as follows.

3.42g (0.01mol) of intermediate IIc was addedIn a 250 mL reaction flask,Then add 30g acetonitrile,Add 1.2g of triethylamine,10 g of acetonitrile and 1.27 g (0.01 mol) were added dropwise with stirring.a mixture of 2-cyanoimido-1,3-thiazolidine,After the completion of the dropwise addition, the reaction was heated to reflux for 2 h.TLC tracking intermediate IIc reaction is complete,After adding 150 g of water and stirring, a solid precipitated.Filtered, dried, A pale yellow solid was obtained in 4.14 g, yield 96%.

The synthetic route of 26364-65-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Qingdao University of Science and Technology; Wang Minghui; Xu Liangzhong; Peng Zhuang; Cui Huanqi; Sun Jianxin; (7 pag.)CN109336882; (2019); A;,
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26364-65-8, 2-Cyanoimino-1,3-thiazolidine is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a 100 ml three-necked flask equipped with a thermometer and an electromagnetic stir bar were added 0.01 mol of anhydrous K2CO3 powder, 0.01 mol of 2-nitroaniline,30 ml of acetone,A solution prepared by dissolving 0.01 mol of 1,3-dimethyl-4-pyrazolecarboxylic acid chloride in 20 ml of acetone was gradually added dropwise at low temperature (0 to 5 C), and the reaction was continued at room temperature for 10 hours. The reaction mixture was filtered under reduced pressure, and the resulting filtrate was decompressed to yield a crude product of compound Q110907. The crude product of compound Q110907 was recrystallized from acetonitrile to give the compound (Q110907) in a yield of 42.9%. Using Thiazoline-2-imino-cyanamide instead of 2-nitroaniline; Acetonitrile was used as the reaction solvent; reaction temperature was 45 ¡À 5 C; reaction time was 8 hours; toluene recrystallization

As the paragraph descriping shows that 26364-65-8 is playing an increasingly important role.

Reference£º
Patent; Qingdao Agricultural University; sun, Jia Long; (11 pag.)CN103524417; (2016); B;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.171877-39-7,(S)-4-Benzylthiazolidine-2-thione,as a common compound, the synthetic route is as follows.

General procedure: Under N2 atmosphere, NaH (120 mg, 60% dispersion in mineral oil, 3 mmol)was added to a solution of thiazolidine-2-thione 2 (2.5 mmol) in 5 mL of THF and the resulting solution was cooled to 78C by a dry-ice-acetone bath. Propionyl chloride(255 mg, 2.5 mmol, 480 muL) was then dropped in. After removal of the solvent in vacuo,the residue was purified by column chromatography with a mixture of petroleum ether(60-90C)/EtOAc (5:1, v/v) as eluent.

171877-39-7 (S)-4-Benzylthiazolidine-2-thione 11458470, athiazolidine compound, is more and more widely used in various.

Reference£º
Article; Chen, Ning; Du, Hongguang; Liu, Weidong; Wang, Shanshan; Li, Xinyao; Xu, Jiaxi; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 190; 1; (2015); p. 112 – 122;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5908-62-3,1,1-Dioxo-isothiazolidine,as a common compound, the synthetic route is as follows.

Example 19 6-[(1,1-Dioxido-1,2-thiazolidin-2-yl)methyl]-3-ethyl-5-(trifluoromethyl)-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 74 mg (0.612 mmol) of propane sultam were dissolved in 1.5 ml of DMF, 24 mg (0.612 mmol) of sodium hydride (60% suspension in mineral oil) were added and the mixture was stirred at RT for 25 min. This was followed by dilution with 0.25 ml of THF (“Mixture 1”). In another reaction vessel, 50 mg (0.122 mmol) of the compound from Example 182A were dissolved in 1 ml of DMF, and 350 mul of Mixture 1 were added dropwise at 0 C. After 2.5 h at 0 C., a further 350 mul of Mixture 1 were added. After a further 30 min at 0 C., the reaction mixture was separated directly into its components by means of preparative HPLC (Method 8). Concentration of the product fractions and drying under high vacuum gave 42 mg (69% of theory) of the title compound. 1H-NMR (400 MHz, CDCl3, delta/ppm): 4.57 (d, 2H), 4.23-4.14 (m, 2H), 4.08 (q, 2H), 3.40 (t, 2H), 3.31-3.19 (m, 2H), 2.74-2.57 (m, 2H), 2.53-2.38 (m, 2H), 1.26 (t, 3H). LC/MS (Method 1, ESIpos): Rt=0.98 min, m/z=494 [M+H]+.

As the paragraph descriping shows that 5908-62-3 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HAeRTER, Michael; KOSEMUND, Dirk; DELBECK, Martina; KALTHOF, Bernd; WASNAIRE, Pierre; SUessMEIER, Frank; LUSTIG, Klemens; (369 pag.)US2018/65981; (2018); A1;,
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7025-19-6, 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 1.75 g (10.0 mmol) of an aldehyde derivative (2) in 20 mL of toluene were added 1.13 g (10.0 mmol) of rhodanine-3-propionic acid and 2.5 g (30.0 mmol) of piperidine, followed by stirring under reflux for 2.5 hours. After completion of the reaction, the mixture was cooled to room temperature, diluted with 100 mL of toluene, supplemented with 100 mL of water, and stirred. After the whole had been left to stand still, an organic layer was separated and dried over anhydrous sodium sulfate. After filtration, toluene was distilled off under reduced pressure, and recrystallization of the residue from ethanol afforded 1.6 g (yield: 43.2%) of a target product (8).

7025-19-6 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid 81492, athiazolidine compound, is more and more widely used in various.

Reference£º
Patent; CANON KABUSHIKI KAISHA; Tanaka, Toshio; Watanabe, Kohei; Nomoto, Tsuyoshi; Okano, Mie; Shintou, Taichi; Miyazaki, Takeshi; Nishimura, Yuhei; Shimada, Yasuhito; (39 pag.)US10227337; (2019); B2;,
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1438-16-0, 3-Aminorhodanine is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of aminorhodanine (1 mmol), isatin (1 mmol) and 5 muL of acetic acid in 2mL of distilled ethanol was placed in a cylindrical quartz reactor (Phi = 4 cm). The reactor was introducedinto a monomode microwave (Anton Paar) apparatus, for 5 min at100 C and 50 Watts. The crude reaction mixture was allowed tocool down at room temperature and ethanol (10 mL) or mixture of H2O/EtOH (10 mL) was directly added in the cylindrical quartzreactor. The resulting precipitated product was filtered off and waspurified by recrystallization from ethanol if necessary.

As the paragraph descriping shows that 1438-16-0 is playing an increasingly important role.

Reference£º
Article; Khaldoun, Khadidja; Safer, Abdelmounaim; Boukabcha, Nourdine; Dege, Necmi; Ruchaud, Sandrine; Souab, Mohamed; Bach, Stephane; Chouaih, Abdelkader; Saidi-Besbes, Salima; Journal of Molecular Structure; vol. 1192; (2019); p. 82 – 90;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1438-16-0,3-Aminorhodanine,as a common compound, the synthetic route is as follows.

A solution of 3,5-dibromo-2-hydroxybenzaldehyde (104 mg, 0.371 mmol) in methanol (1 ML) was added to a solution of 3-aminorhodanine (50 mg, 0.337 mmol) in methanol (5 ML) and the mixture allowed to stand at room temperature.. After 1 h, the precipitate was filtered, washed (methanol, ether) and dried to give the title compound (93 mg, 67%) as a pale yellow solid. LCMS m/e 409, 411, 413 [M+H]+.

1438-16-0 3-Aminorhodanine 74033, athiazolidine compound, is more and more widely used in various.

Reference£º
Patent; SmithKline Beecham Corporation; US6720345; (2004); B1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7025-19-6,3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid,as a common compound, the synthetic route is as follows.

[00161] To a solution of 2,3-dimethoxybenzaldehyde 1 (200 mg, 1.20 mmol) and 3-(4- oxo-2-thioxothiazolidin-3-yl)propanoic acid 2 (247 mg, 1.20 mmol) in glacial acetic acid (4 mL) was added sodium acetate (197 mg, 2.41 mmol) and the reaction was heated at 90 C for 6 h. After the completion of reaction (as monitored by LCMS) the reaction mixture was poured into ice cooled water, stirred for 15 mm and the solid precipitated out was filtered, washed with diethyl ether and dried in vacuo to afford 235 mg (55% yield) of NADi-241 as yellow solid. ?H NMR (400 MHz, DMSO-d6) 12.50 (s, 1 H), 7.89 (s, 1 H), 7.25 (d, J = 1.87 Hz, 2 H), 7.06 (dd, J = 3.74, 5.62 Hz, 1 H), 4.20 – 4.26 (m, 2 H), 3.86 (s, 3 H), 3.82 (s, 3 H), 2.61 – 2.66 (m, 2 H) ; MS (ES+): mlz = 353.90 [M+Hj; HPLC = 99.28%.

The synthetic route of 7025-19-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITY OF MIAMI; UNIVERSITY OF MARYLAND, BALTIMORE; SPYVEE, Mark; CAPOBIANCO, Anthony, J.; MACKERELL, Alex, Jr.; (114 pag.)WO2016/154255; (2016); A1;,
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