Heterocyclic Building Blocks-Thiazolidine

Spectrophotometric and spectrofluorimetric determination of mesna, acetylcysteine and timonacic acid through the reaction with acetoxymercuri fluorescein was written by Haggag, Rim S.;Gawad, Dina A.;Belal, Saeid F.;Elbardisy, Hadil M.. And the article was included in Analytical Methods in 2016.COA of Formula: C4H7NO2S This article mentions the following:

Simple, sensitive and specific spectrophotometric (Method I) and spectrofluorimetric (Method II) methods were developed for the determination of three sulfur-containing drugs: mesna (MSN), acetylcysteine (ACT) and timonacic acid (TMN). The methods are based on the suppressive effect of the drugs on the absorbance and the fluorescence intensity of 2′,7′-bis(acetoxymercuri)fluorescein (AMF) in 0.05 M borate buffer. In Method I the decrease in AMF absorbance was measured at 497 nm, while in Method II the fluorescence quenching of the reagent was measured at λ_em 520 nm (λ_ex 497 nm). All the exptl. parameters affecting this reaction were studied and optimized. The selectivity and the stability-indicating aspect of the methods were confirmed and no interference was detected from the oxidation products of the quantified drugs or from other co-administered drugs. Method I was applicable over the concentration ranges 0.5-3, 0.5-2.75 and 0.25-2.75 μg mL^-1 for MSN, ACT and TMN, resp. The reaction sensitivity was enhanced by Method II where the linearity ranges were found to be 0.6-7.2, 0.7-7 and 0.8-10.4 ng mL^-1 for MSN, ACT and TMN, resp. Both methods were applied for the determination of the three drugs in bulk form and in their pharmaceutical preparations without interference from common excipients. The percentage recoveries were satisfactory and they were statistically compared with those obtained from previously reported methods. Moreover, Method II was extended to analyze the drugs in spiked human plasma, by virtue of its high sensitivity. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9COA of Formula: C4H7NO2S).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.COA of Formula: C4H7NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Combined nitrogen limitation and cadmium stress stimulate total carbohydrates, lipids, protein and amino acid accumulation in Chlorella vulgaris (Trebouxiophyceae) was written by Chia, Mathias Ahii;Lombardi, Ana Teresa;da Graca Gama Melao, Maria;Parrish, Christopher C.. And the article was included in Aquatic Toxicology in 2015.Product Details of 444-27-9 This article mentions the following:

Metals have interactive effects on the uptake and metabolism of nutrients in microalgae. However, the effect of trace metal toxicity on amino acid composition of Chlorella vulgaris as a function of varying nitrogen concentrations is not known. In this research, C. vulgaris was used to investigate the influence of cadmium (10^-7 and 2.0 × 10^-8 mol L^-1 Cd) under varying nitrogen (2.9 × 10^-6, 1.1 × 10^-5 and 1.1 × 10^-3 mol L^-1 N) concentrations on its growth rate, biomass and biochem. composition Total carbohydrates, total proteins, total lipids, as well as individual amino acid proportions were determined The combination of Cd stress and N limitation significantly inhibited growth rate and cell d. of C. vulgaris. However, increasing N limitation and Cd stress stimulated higher dry weight and chlorophyll a production per cell. Furthermore, biomols. like total proteins, carbohydrates and lipids increased with increasing N limitation and Cd stress. Ketogenic and glucogenic amino acids were accumulated under the stress conditions investigated in the present study. Amino acids involved in metal chelation like proline, histidine and glutamine were significantly increased after exposure to combined Cd stress and N limitation. We conclude that N limitation and Cd stress affects the physiol. of C. vulgaris by not only decreasing its growth but also stimulating biomol. production In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Product Details of 444-27-9).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Product Details of 444-27-9

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Synthesis of Chiral Tryptamines via a Regioselective Indole Alkylation was written by Wolfard, Jens;Xu, Jie;Zhang, Haiming;Chung, Cheol K.. And the article was included in Organic Letters in 2018.Category: thiazolidine This article mentions the following:

A practical synthesis of chiral tryptamines from simple, unprotected indoles has been developed. Indole nucleophiles prepared with MeMgCl in the presence of CuCl reacted with chiral cyclic sulfamidates almost exclusively at the C³-position of indole to form a variety of α- and/or β-substituted chiral tryptamines in good yield with excellent regioselectivity. The utility of this simple alkylation process has been demonstrated with the practical synthesis of two biol. active targets, cipargamin and TIK-301, which were completed in three steps starting from the corresponding indole starting materials. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl 4-phenyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide (cas: 479687-23-5Category: thiazolidine).

(S)-tert-Butyl 4-phenyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide (cas: 479687-23-5) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Category: thiazolidine

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides was written by Hartman, Matthew C. T.;Josephson, Kristopher;Lin, Chi-Wang;Szostak, Jack W.. And the article was included in PLoS One in 2007.Formula: C4H7NO2S This article mentions the following:

The application of in vitro translation to the synthesis of unnatural peptides may allow the production of extremely large libraries of highly modified peptides, which are a potential source of lead compounds in the search for new pharmaceutical agents. The specificity of the translation apparatus, however, limits the diversity of unnatural amino acids that can be incorporated into peptides by ribosomal translation. We have previously shown that over 90 unnatural amino acids can be enzymically loaded onto tRNA. We have now used a competition assay to assess the efficiency of tRNA-aminoacylation of these analogs. We have also used a series of peptide translation assays to measure the efficiency with which these analogs are incorporated into peptides. The translation apparatus tolerates most side chain derivatives, a few α,α disubstituted, N-Me and α-hydroxy derivatives, but no β-amino acids. We show that over 50 unnatural amino acids can be incorporated into peptides by ribosomal translation. Using a set of analogs that are efficiently charged and translated we were able to prepare individual peptides containing up to 13 different unnatural amino acids. Our results demonstrate that a diverse array of unnatural building blocks can be translationally incorporated into peptides. These building blocks provide new opportunities for in vitro selections with highly modified drug-like peptides. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Formula: C4H7NO2S).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine is an important scaffold and has a wide range of promising biological activities. Thiazolidine derivatives have reported anti-inflammatory and anti-nociceptive activity. Thiazolidines unsubstituted on the nitrogen atom are readily hydrolyzed by boiling aqueous solutions of acids or bases and the dissociation is complete in the presence of a compound reacting with one of the cleavage products.Formula: C4H7NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Expedient Synthesis of Highly Functionalised Cyclic Imines was written by Moss, Thomas A.. And the article was included in Synlett in 2015.SDS of cas: 454248-53-4 This article mentions the following:

Aryl- and heteroaryl fused cyclic imines were obtained from the starting acetal via a directed metalation-alkylation-condensation sequence using cyclic sulfamidates as the electrophile. A variety of aromatics and heteroaromatics are applicable to this methodol., which produces highly versatile cyclic imine building blocks for drug discovery and total synthesis programs. In the experiment, the researchers used many compounds, for example, (R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4SDS of cas: 454248-53-4).

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.SDS of cas: 454248-53-4

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Transformation between 2-Threityl-thiazolidine-4-carboxylic Acid and Xylose-Cysteine Amadori Rearrangement Product Regulated by pH Adjustment during High-Temperature Instantaneous Dehydration was written by Zhai, Yun;Cui, Heping;Hayat, Khizar;Hussain, Shahzad;Tahir, Muhammad Usman;Deng, Shibin;Zhang, Qiang;Zhang, Xiaoming;Ho, Chi-Tang. And the article was included in Journal of Agricultural and Food Chemistry in 2020.Reference of 444-27-9 This article mentions the following:

2-Threityl-thiazolidine-4-carboxylic acid (TTCA) was found to be the predominant product rather than the Amadori rearrangement product (ARP) during the formation of xylose-cysteine-derived (Xyl-Cys-derived) Maillard reaction intermediates (MRIs) through a thermal reaction coupled with vacuum dehydration. To regulate the existence forms of Xyl-Cys-derived MRIs, an effective method carried out by pH adjustment during high-temperature instantaneous dehydration through spray-drying was proposed in this research to promote the conversion from TTCA to ARP. The increased inlet air temperature of spray-drying could properly facilitate the shift of chem. equilibrium between the MRIs and promote the transformation from TTCA to ARP while raising the total yield of TA (TTCA + ARP). The conversion to ARP was increased to 20.83% at 190°C of hot blast compared to the product without spray-drying (6.03%). The conversion from TTCA to ARP was further facilitated in the pH range of 7.5-9.5. When the pH of the aqueous reactants was adjusted to 9.5, the equilibrium conversion to ARP was improved to 47.23% after spray-drying, which accounted for 59.48% of the TA formation. Accordingly, MRIs with different TTCA/ARP proportions could be selectively obtained by pH adjustment of the stock solution during high-temperature instantaneous dehydration of spray-drying. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Reference of 444-27-9).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Reference of 444-27-9

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Enantioselective synthesis of structurally intricate and complementary poly-oxygenated building blocks of spongistatin 1 (altohyrtin A) was written by Braun, Alain;Cho, Il Hwan;Ciblat, Stephane;Clyne, Dean;Forgione, Pat;Hart, Amy C.;Huang, Guoxiang;Kim, Jungchul;Modolo, Isabelle;Paquette, Leo A.;Peng, Xiaowen;Pichlmair, Stefan;Stewart, Catherine A.;Wang, Jizhou;Zuev, Dmitry. And the article was included in Collection of Czechoslovak Chemical Communications in 2009.Recommanded Product: (S)-4-Isopropylthiazolidine-2-thione This article mentions the following:

Enantioselective approaches to the construction of four complex building blocks of the structurally intricate marine macrolide known as spongistatin 1 are presented. The first phase of the synthetic effort relies on a practical approach to a enantiomerically pure spiroketal ring system incorporating rings A and B. Concurrently, the C17-C28 subunit, which houses one-fifth of the stereogenic centers of the target in the form of rings C and D, was assembled via a composite of stereocontrolled aldol condensations. Once arrival at the entire C1-C28 sector had been realized, routes were devised to provide two addnl. highly functionalized sectors consisting of C29-C44 and C38-C51. A series of subsequent transformations including cyclization of the E ring and hydroboration to afford the B-alkyl intermediate for the key Suzuki coupling to append the side chain took advantage of efficient stereocontrol. Ultimately, complete assembly and functionalization of the western EF sector of spongistatin was thwarted by an inoperative Suzuki coupling step intended to join the side chain to the C29-C44 sector, and later because of complications due to protecting groups, which precluded the complete elaboration of the late stage C29-C51 intermediate. In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4Recommanded Product: (S)-4-Isopropylthiazolidine-2-thione).

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Open-chain compounds are obtained when thiazolidines are treated with tris(trimethylsilyl)silane in a reaction in which the thiazolidine derivatives act as a source of α-aminoalkyl radicals.Recommanded Product: (S)-4-Isopropylthiazolidine-2-thione

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Crystal structure of 7′-(4-chlorophenyl)-2′′-(4-methoxyphenyl)-7′,7a′,7′′,8′′-tetrahydro-1′H,3′H,5′′H-dispiro[indoline-3,5′-pyrrolo[1,2-c]thiazole-6′,6′′-quinoline]-2,5′′-dione and an unknown solvent was written by Vishnupriya, R.;Venkateshan, M.;Suresh, J.;Sumesh, R. V.;Kumar, R. Ranjith;Lakshman, P. L. Nilantha. And the article was included in Acta Crystallographica, Section E: Crystallographic Communications in 2019.Quality Control of Thiazolidine-4-carboxylic acid This article mentions the following:

The asym. unit of the title compound, C₃₄H₂₈ClN₃O₃S, contains two independent mols. (A and B). They differ essentially in the orientation of the 4-methoxyphenyl ring with respect to the pyridine ring of the quinoline moiety; this dihedral angle is 37.01 (18)° in mol. A but only 7.06 (17)° in mol. B. In both mols., the cyclohexanone ring of the isoquinoline unit has a half-chair conformation. In the pyrrolothiazole ring system, the pyrrolo ring in mol. A has a twisted conformation on the N-C fused bond and an envelope conformation in mol. B with the N atom as the flap. The thiazole rings of both mols. have twisted conformations on the N-C fused bond. In the crystal, the A mols. are linked by pairs of N-H···O hydrogen bonds, forming inversion dimers with an R²2(8) ring motif. These dimers are linked to the B mols. by an N-H···N hydrogen bond and a series of C-H···O hydrogen bonds, forming layers lying parallel to the (101) plane. The layers are linked by C-H···π interactions and offset π-π interactions [intercentroid distance = 3.427 (1) Å], forming a supramol. framework. The contribution to the scattering from a region of highly disordered solvent mols. was removed with the SQUEEZE routine in PLATON [Spek (2015). Acta Crystalline C71, 9-18]. The solvent formula mass and unit-cell characteristics were not taken into account during refinement. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Quality Control of Thiazolidine-4-carboxylic acid).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Quality Control of Thiazolidine-4-carboxylic acid

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Characterizing the Flavor Precursors and Liberation Mechanisms of Various Dry-Aging Methods in Cull Beef Loins Using Metabolomics and Microbiome Approaches was written by Setyabrata, Derico;Vierck, Kelly;Sheets, Tessa R.;Legako, Jerrad F.;Cooper, Bruce R.;Johnson, Timothy A.;Kim, Yuan H. Brad. And the article was included in Metabolites in 2022.Reference of 444-27-9 This article mentions the following:

The objective of this study was to characterize and compare the dry-aging flavor precursors and their liberation mechanisms in beef aged with different methods. Thirteen paired loins were collected at 5 days postmortem, divided into four sections, and randomly assigned into four aging methods (wet-aging (WA), conventional dry-aging (DA), dry-aging in a water-permeable bag (DWA), and UV-light dry-aging (UDA)). All sections were aged for 28 days at 2 °C, 65% RH, and a 0.8 m/s airflow before trimming and sample collection for chem., metabolomics, and microbiome analyses. Higher concentrations of free amino acids and reducing sugars were observed in all dry-aging samples (p < 0.05). Similarly, metabolomics revealed greater short-chain peptides in the dry-aged beef (p < 0.05). The DWA samples had an increase in polyunsaturated free fatty acids (C18:2trans, C18:3n3, C20:2, and C20:5; p < 0.05) along with higher volatile compound concentrations compared to other aging methods (aldehyde, nonanal, octanal, octanol, and carbon disulfide; p < 0.05). Microbiome profiling identified a clear separation in beta diversity between dry and wet aging methods. The Pseudomonas spp. are the most prominent bacterial species in dry-aged meat, potentially contributing to the greater accumulation of flavor precursor concentrations in addition to the dehydration process during the dry-aging. Minor microbial species involvement, such as Bacillus spp., could potentially liberate unique and potent flavor precursors. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Reference of 444-27-9).

Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Open-chain compounds are obtained when thiazolidines are treated with tris(trimethylsilyl)silane in a reaction in which the thiazolidine derivatives act as a source of α-aminoalkyl radicals.Reference of 444-27-9

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Endogenous alkaloids in man. XI. Analysis of glyoxylate-derived 1,3-thiazolidines by ion-pair-assisted reversed-phase chromatography was written by Bringmann, Gerhard;Hesselmann, Christiana;Feineis, Doris. And the article was included in Journal of Chromatography in 1992.Electric Literature of C4H7NO2S This article mentions the following:

Reversed-phase ion-pair chromatog., using cetyltrimethyl ammonium hydrogen sulfate as detergent was applied to the anal. of the highly polar glyoxylate-derived 1,3-thiazolidines. On the base of this, HPLC graphic separation of diastereomeric compounds was achieved. Removal of the hydrophobic counterion by precipitation as its insoluble iodide, followed by an extraction with chloroform, seems to be a promising first step to establish ion-pair-assisted chromatog. as a preparative HPLC method for the isolation of polar compounds In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Electric Literature of C4H7NO2S).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Electric Literature of C4H7NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com