Kise, Naoki et al. published their research in Journal of Organic Chemistry in 1998 | CAS: 76186-04-4

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine is an important scaffold and has a wide range of promising biological activities. Thiazolidine derivatives have reported anti-inflammatory and anti-nociceptive activity. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Related Products of 76186-04-4

Stereoselective Hydrocoupling of Optically Active 3-trans-Cinnamoyloxazolidinones by Electroreduction was written by Kise, Naoki;Mashiba, Syun-ichiro;Ueda, Nasuo. And the article was included in Journal of Organic Chemistry in 1998.Related Products of 76186-04-4 This article mentions the following:

Reductive hydrocoupling of chiral 3-trans-cinnamoyloxazolidinones was studied by an electrochem. method. The electroreduction was performed conveniently at a constant current using an undivided cell. The stereoselectivity of the hydrodimers was strongly affected by the electrolyte employed. Electroreduction of (S)-4-isobutyl-3-trans-cinnamoyloxazolidinone (I) in 0.3 M Et4NOTs/AN gave a mixture of two diastereomers of all-trans cyclized hydrodimer, and the selectivity was R,S,R/S,R,S = 85:15. On the other hand, the reduction of I in 1.7 M LiClO4/THF afforded a diastereomeric mixture of hydrodimers in a selectivity of R,R/S,S/R,S = 5:52:43. The stereoselectivities were explained by considering stable conformations of intermediate anion radicals, i.e., syn-Z type for naked anion radicals and anti-Z type for lithiated anion radicals. Semiempirical calculations also supported this hypothesis. Electroreductions of (S)-4-isobutyl-3-cis-cinnamoyloxazolidinone and (S)-4-isobutyl-3-phenylpropioloyloxazolidinone gave the same stereoselectivity as electroreduction of I did. The electroreductive hydrocoupling was not inhibited by para and meta substitution on the aryl group of 3-trans-cinnamoyloxazolidinones. An ortho substitution, however, hindered the hydrocoupling and lowered the stereoselectivity of the hydrodimers. Electroreduction of 3-trans-cinnamoyloxazolidinethione and thiazolidinethione gave trans-3,4-diphenylcyclopentanone as a product, and the stereoselectivities were similar to that obtained from the corresponding oxazolidinone. In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4Related Products of 76186-04-4).

(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine is an important scaffold and has a wide range of promising biological activities. Thiazolidine derivatives have reported anti-inflammatory and anti-nociceptive activity. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Related Products of 76186-04-4

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Kotha, Sambasivarao et al. published their research in Beilstein Journal of Organic Chemistry in 2019 | CAS: 16312-21-3

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Computed Properties of C4H5NO2S

Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation was written by Kotha, Sambasivarao;Sreevani, Gaddamedi;Dzhemileva, Lilya U.;Yunusbaeva, Milyausha M.;Dzhemilev, Usein M.;D’yakonov, Vladimir A.. And the article was included in Beilstein Journal of Organic Chemistry in 2019.Computed Properties of C4H5NO2S This article mentions the following:

A new synthetic approach was reported to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chem. and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alc. derivatives of thiazolidine-2,4-dione generated here are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562 cell lines. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Computed Properties of C4H5NO2S).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Computed Properties of C4H5NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Turkevich, N. M. et al. published their research in Khim. Geterotsikl. Soedin., Sb. 3 in 1971 | CAS: 16312-21-3

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Synthetic Route of C4H5NO2S

2,4-Thiazolidinedione derivatives was written by Turkevich, N. M.;Yurzhenko, S. A.. And the article was included in Khim. Geterotsikl. Soedin., Sb. 3 in 1971.Synthetic Route of C4H5NO2S This article mentions the following:

Reaction of 2,4-thiazolidinedione (I) with KOH gave the K salt which with Me2SO4 or the appropriate halogen compound gave the following II (R and % yield given): Me, 65; Et, 46; CH2CO2Me, 62; Et2NCH2CH2, 46; PhCH2, 85; 2,4-(O2N)2C6H3, 30. Heating I K salt with an acyl chloride gave the following II (same data given): Bz, 64; p-O2NC6H4CO, 56; Ph2CHCO, 42; Ph2CClCO, 62. Reaction of I with p-O2NC6H4CHO gave 85% III (R = H), which with KOH, then RCl gave 76% III (R = PhCH2) (IV), and 69% III (R = Et2NCH2CH2). Refluxing IV with N2H4.H2O in alc. gave the azine. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Synthetic Route of C4H5NO2S).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Synthetic Route of C4H5NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Heerding, Dirk A. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2003 | CAS: 16312-21-3

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Safety of 3-Methylthiazolidine-2,4-dione

New Benzylidenethiazolidinediones as Antibacterial Agents was written by Heerding, Dirk A.;Christmann, Lisa T.;Clark, Tammy J.;Holmes, David J.;Rittenhouse, Stephen F.;Takata, Dennis T.;Venslavsky, Joseph W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Safety of 3-Methylthiazolidine-2,4-dione This article mentions the following:

A novel benzylidenethiazolidinedione has been discovered with antimicrobial activity. Here, we present the results of a structure-activity study on this compound with respect to its antimicrobial activity. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Safety of 3-Methylthiazolidine-2,4-dione).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Safety of 3-Methylthiazolidine-2,4-dione

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Imrich, Jan et al. published their research in Collection of Czechoslovak Chemical Communications in 1996 | CAS: 16312-21-3

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Application In Synthesis of 3-Methylthiazolidine-2,4-dione

Reaction of O-alkyl-N-substituted iminothiocarbonates with bromoacetyl bromide. A general method for the synthesis of 3-substituted 1,3-thiazolidine-2,4-diones was written by Imrich, Jan;Bernat, Juraj;Kristian, Pavol;Busova, Tatiana;Hocova, Slavka. And the article was included in Collection of Czechoslovak Chemical Communications in 1996.Application In Synthesis of 3-Methylthiazolidine-2,4-dione This article mentions the following:

Reaction of O-methyl-N-substituted iminothiocarbonate sodium salts RN:C(OMe)SNa [R = (substituted) 9-acridinyl, Me, (substituted) Ph, 1-naphthyl, 1-naphthylmethyl] with bromoacetyl bromide represents a new general method for preparation of 3-substituted 1,3-thiazolidine-2,4-diones I in good yields and high purity. The structure of the synthesized products has been confirmed by 1H NMR, 13C NMR, IR, and mass spectroscopy as well as by independent synthesis. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Application In Synthesis of 3-Methylthiazolidine-2,4-dione).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Application In Synthesis of 3-Methylthiazolidine-2,4-dione

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Hanefeld, Wolfgang et al. published their research in Liebigs Annalen der Chemie in 1986 | CAS: 16312-21-3

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidines undergo hydrolysis to aldehyde and amino thiol under acid or basic aqueous conditions. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.SDS of cas: 16312-21-3

Oxidation of thiocarbamidates. 10. α-Carbamoyl sulfoxides and sulfones. 2. Formation of thiosulfonates by hydrolysis of cyclic α-carbamoyl sulfoxides was written by Hanefeld, Wolfgang;Jalili, Mohamed A.. And the article was included in Liebigs Annalen der Chemie in 1986.SDS of cas: 16312-21-3 This article mentions the following:

RNHCOCH2CH2SO2SCH2CH2CONHR (R = Me, Ph, PhCH2, PhCH2CH2) and RNHCOCH2SO2SCH2CONHR (R = Ph, PhCH2, p-ClC6H4CH2) were prepared by hydrolysis of the thiazine oxides I and thiazolidine oxide II. Structures were confirmed by independent synthesis. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3SDS of cas: 16312-21-3).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidines undergo hydrolysis to aldehyde and amino thiol under acid or basic aqueous conditions. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.SDS of cas: 16312-21-3

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Turkevich, N. M. et al. published their research in Khimiya Geterotsiklicheskikh Soedinenii, Sbornik in 1971 | CAS: 16312-21-3

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Recommanded Product: 3-Methylthiazolidine-2,4-dione

Synthesis and properties of 2,4-thiazolidinedione derivatives was written by Turkevich, N. M.;Yurzhenko, S. A.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii, Sbornik in 1971.Recommanded Product: 3-Methylthiazolidine-2,4-dione This article mentions the following:

Heating 2,4-thiazolidinedione K salt, (I, R1 = K, R2 = H2) (II) or its 5-p-nitrobenzylidene derivative (I, R1 = K, R2 = CHC6H4NO2-p) with alkylating agent in Me2CO or DMF gave 3-alkyl derivatives [I, R1 = Me, Et, CH2CO2Me, (CH2)2NEt2, CH2Ph, C6H3-(NO2)2-3,4]. II and acyl halides in Me2CO yielded 3-acyl derivatives [I, R1 = Bz, COC6H4NO2-p, COCHPh2, COCClPh2]. Refluxing I (R1 = CH2Ph, R2 = CHC6H4NO2-p) with N2H4.H2O in EtOH 3 hr gave p-nitrobenzaldazine. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Recommanded Product: 3-Methylthiazolidine-2,4-dione).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Recommanded Product: 3-Methylthiazolidine-2,4-dione

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Paladhi, Sushovan et al. published their research in Green Chemistry in 2012 | CAS: 16312-21-3

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Recommanded Product: 16312-21-3

An uncatalyzed aldol reaction of thiazolidinediones was written by Paladhi, Sushovan;Chauhan, Ajay;Dhara, Kalyan;Tiwari, Ashwani Kumar;Dash, Jyotirmayee. And the article was included in Green Chemistry in 2012.Recommanded Product: 16312-21-3 This article mentions the following:

Thiazolidinediones have been used as aldol donors with aromatic aldehydes “on water” and in DMSO without using any catalyst to give the corresponding β-hydroxy carbonyl compounds in high yield and purity. The p-cyano and p-nitro substituted aldol products undergo syn/anti isomerization via an enolization mechanism providing an “on water” diastereoselectivity switch. Water mols. play a significant role in stabilizing the syn aldol products of pyridine and thiazole containing aldehydes. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Recommanded Product: 16312-21-3).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Recommanded Product: 16312-21-3

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Mital, Alka et al. published their research in European Journal of Medicinal Chemistry in 2015 | CAS: 16312-21-3

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Computed Properties of C4H5NO2S

Discovery and optimisation studies of antimalarial phenotypic hits was written by Mital, Alka;Murugesan, Dinakaran;Kaiser, Marcel;Yeates, Clive;Gilbert, Ian H.. And the article was included in European Journal of Medicinal Chemistry in 2015.Computed Properties of C4H5NO2S This article mentions the following:

There is an urgent need for the development of new antimalarial compounds As a result of a phenotypic screen, several compounds with potent activity against the parasite Plasmodium falciparum were identified. Characterization of these compounds is discussed, along with approaches to optimize the physicochem. properties. The in vitro antimalarial activity of these compounds against P. falciparum K1 had EC50 values in the range of 0.09-29 μM, and generally good selectivity (typically >100-fold) compared to a mammalian cell line (L6). One example showed no significant activity against a rodent model of malaria, and more work is needed to optimize these compounds In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Computed Properties of C4H5NO2S).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Computed Properties of C4H5NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Kotha, Sambasivarao et al. published their research in Journal of Chemical Sciences (Berlin, Germany) in 2022 | CAS: 16312-21-3

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Name: 3-Methylthiazolidine-2,4-dione

Design and synthesis of amino acid derivatives containing hydantoin and thiazolidine moieties was written by Kotha, Sambasivarao;Gaikwad, Vidyasagar. And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2022.Name: 3-Methylthiazolidine-2,4-dione This article mentions the following:

A simple synthetic approach to N-Me spiro hydantoins such as I and thiazolidine containing amino acid derivatives such as 5,6-bis(bromomethyl)-3′-methyl-1,3-dihydrospiro[indene-2,5′-thiazolidine]-2′,4′-dione by coupling 1,2,4,5-tetrakis(bromomethyl) benzene with Et isocyanoacetate (EICA) as a glycine equivalent was reported. Normally, α-amino acids are derived from hydantoin, wherein the hydantoin and amino acid moieties are incorporated in the same mols. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Name: 3-Methylthiazolidine-2,4-dione).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Name: 3-Methylthiazolidine-2,4-dione

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com