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Synthesis of Some C-5 Substituted 4-Phenylimino-Thiazolidin-2-Ones as Possible Anti-Inflammatory Agents
Based on the Knoevenagel condensation, nitrosation, and azo coupling reactions, the synthesis of some C-5 substituted 4-phenylimino-thiazolidin-2-ones was carried out. The chemical structures of the synthesized products have been determined by H-1 NMR spectroscopy and elemental analysis. Evaluation of novel compounds over the carrageenan-summoned rat paw edema revealed a powerful anti-inflammatory effect of some substances which exceeds the activity of the comparative drug Ibuprofen.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com