Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Computed Properties of C4H4O2, 922-67-8, Name is Methyl propiolate, molecular formula is C4H4O2, belongs to thiazolidines compound. In a document, author is Popiolek, Lukasz, introduce the new discover.
New nalidixic acid-1,3-thiazolidin-4-one hybrids: Design, synthesis and in vitro antimicrobial activity
In this paper, 14 new nalidixic acid-1,3-thiazolidin-4-one hybrid compounds (17-30) were synthesized by the cyclization reaction of corresponding N-substituted nalidixic acid hydrazones (3-16) with mercaptoacetic acid in the presence of 1,4-dioxane. The structures of the obtained compounds were confirmed by means of H-1 NMR and C-13 NMR spectroscopy. All newly synthesized hybrids were screened in vitro for antimicrobial activity. The antimicrobial activity assay indicated that compounds 17-30 showed good to moderate antimicrobial activity, especially against Gram-positive bacteria. Moreover, compound 29 inhibited growth of reference strains of Gram-negative bacteria belonging to Enterobacteriaceae family.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com