With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7025-19-6,3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid,as a common compound, the synthetic route is as follows.
[00161] To a solution of 2,3-dimethoxybenzaldehyde 1 (200 mg, 1.20 mmol) and 3-(4- oxo-2-thioxothiazolidin-3-yl)propanoic acid 2 (247 mg, 1.20 mmol) in glacial acetic acid (4 mL) was added sodium acetate (197 mg, 2.41 mmol) and the reaction was heated at 90 C for 6 h. After the completion of reaction (as monitored by LCMS) the reaction mixture was poured into ice cooled water, stirred for 15 mm and the solid precipitated out was filtered, washed with diethyl ether and dried in vacuo to afford 235 mg (55% yield) of NADi-241 as yellow solid. ?H NMR (400 MHz, DMSO-d6) 12.50 (s, 1 H), 7.89 (s, 1 H), 7.25 (d, J = 1.87 Hz, 2 H), 7.06 (dd, J = 3.74, 5.62 Hz, 1 H), 4.20 – 4.26 (m, 2 H), 3.86 (s, 3 H), 3.82 (s, 3 H), 2.61 – 2.66 (m, 2 H) ; MS (ES+): mlz = 353.90 [M+Hj; HPLC = 99.28%.
The synthetic route of 7025-19-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UNIVERSITY OF MIAMI; UNIVERSITY OF MARYLAND, BALTIMORE; SPYVEE, Mark; CAPOBIANCO, Anthony, J.; MACKERELL, Alex, Jr.; (114 pag.)WO2016/154255; (2016); A1;,
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