With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5908-62-3,1,1-Dioxo-isothiazolidine,as a common compound, the synthetic route is as follows.,5908-62-3
7 mg (0.03 mmol) of palladium(II) acetate and 18 mg (0.03 mmol) of Xantphos were stirred in 3.6 ml of dioxane under an argon atmosphere at 20 C. for 10 minutes. Then 150 mg (0.3 mmol) of the compound from Example 72A, 74 mg (0.06 mmol) of 1,3-propane sultam and 148 mg (0.46 mmol) of caesium carbonate were added and the mixture was stirred at 110 C. for 6 h. After cooling down to 23 C., the mixture was purified via preparative HPLC (eluent: acetonitrile/water gradient with 0.1% formic acid). This gave 95 mg (51% of theory) of the title compound. LC-MS (Method 1): Rt=1.15 min; m/z=579.2 [M+H]+. 1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1.156 (4.54), 1.174 (8.71), 1.192 (4.39), 1.987 (16.00), 2.297 (4.76), 2.314 (6.89), 2.331 (5.14), 3.577 (4.62), 3.590 (8.77), 3.606 (8.06), 3.634 (2.43), 4.020 (4.03), 4.037 (3.96), 4.815 (3.11), 4.827 (3.16), 4.845 (3.08), 4.859 (2.88), 7.325 (3.46), 7.334 (7.37), 7.356 (6.87), 7.380 (2.99), 7.399 (5.75), 7.420 (4.45), 7.526 (13.43), 7.546 (9.83), 7.555 (3.20), 7.811 (2.87), 7.826 (2.86), 8.595 (6.46), 8.617 (6.25), 8.754 (11.28), 10.157 (2.54), 10.171 (4.84).
The synthetic route of 5908-62-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Bayer Pharma Aktiengesellschaft; TELLER, Henrik; STRAUB, Alexander; BRECHMANN, Markus; MUeLLER, Thomas; MEININGHAUS, Mark; NOWAK-REPPEL, Katrin; TINEL, Hanna; MUeNTER, Klaus; FLIEGNER, Daniela; MONDRITZKI, Thomas; BOULTADAKIS ARAPINIS, Melissa; MARQUARDT, Tobias; VAKALOPOULOS, Alexandros; REBSTOCK, Anne-Sophie; WITTWER, Matthias Beat; (342 pag.)US2018/297994; (2018); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com