With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.26364-65-8,2-Cyanoimino-1,3-thiazolidine,as a common compound, the synthetic route is as follows.
3.42g (0.01mol) of intermediate IIc was addedIn a 250 mL reaction flask,Then add 30g acetonitrile,Add 1.2g of triethylamine,10 g of acetonitrile and 1.27 g (0.01 mol) were added dropwise with stirring.a mixture of 2-cyanoimido-1,3-thiazolidine,After the completion of the dropwise addition, the reaction was heated to reflux for 2 h.TLC tracking intermediate IIc reaction is complete,After adding 150 g of water and stirring, a solid precipitated.Filtered, dried, A pale yellow solid was obtained in 4.14 g, yield 96%.
The synthetic route of 26364-65-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Qingdao University of Science and Technology; Wang Minghui; Xu Liangzhong; Peng Zhuang; Cui Huanqi; Sun Jianxin; (7 pag.)CN109336882; (2019); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com