With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.171877-39-7,(S)-4-Benzylthiazolidine-2-thione,as a common compound, the synthetic route is as follows.
To a solution of (S)-4-benzylthiazolidine-2-thione (1 g, 4.78 mmol) in THF (dry, 50 mL) was added n-BuLi (2.87 mL, 7.17 mmol, 2.5 M) at – 78 C. The resulting mixture was stirred at that temperature for 1 .5 h, then 2-cyclohexylacetyl chloride (1 .10 ml, 7.17 mmol) was added. The temperature was maintained at – 78 C for 2.5 h. Then the reaction mixture was allowed to warm to RT and stirred for 16 h. After an aqueous work up with saturated NH4CI solution the crude product was purified by flash chromatography (cyclohexane) to afford 29 as a yellow crystalline solid (1 .48 g, 4.45 mmol, 93 %). TLC [cyclohexane/EE, 8:2]: Rf = 0.6 Mass (ESI+), calculated 333.12 [C18H23NOS2 + H]+, found = 334.04 [M+H]+
The synthetic route of 171877-39-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; GAALI, Steffen; HAUSCH, Felix; KIRSCHNER, Alexander; FENG, Xiri; BRACHER, Andreas; RUEHTER, Gerd; WO2015/39758; (2015); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com